PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting
Dziadkowiec, Karolina N., Gąsiorowska, Emilia, Nowak-Markwitz, Ewa, Jankowska, Anna·2016·Menopausal Review
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Items 101–191 of 191
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- Phase 1b study to assess the safety, tolerability, and clinical activity of pamiparib in combination with temozolomide in patients with locally advanced or metastatic solid tumorsAgostina Stradella, Melissa Johnson, Sanjay Goel, Haeseong Park, Nehal J. Lakhani, Hendrik‐Tobias Arkenau, Matthew D. Galsky, Emiliano Calvo, Vicente Baz, Víctor Moreno et al. · 2024 · Cancer Medicine
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- Defective DNA repair in hereditary ovarian cancers: Implications for therapyBrian T. Burgess, Jill Kolesar · 2018 · American Journal of Health-System Pharmacy
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- Comprehensive genomic dependency landscape of a human colon cancer organoidSanam Khalili, Atefeh Mohseninia, Changlong Liu, Carolyn E. Banister, Paige Heine, M. Khazan, Sidney E. Morrison, P. Gokare, G. Cowley, Barbara A. Weir et al. · 2025 · Communications Biology
- BRCA1 and BRCA2 associated breast cancer and the roles of current modelling systems in drug discoveryOliver Trusler, Jacob Goodwin, Andrew L. Laslett · 2020 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- A Review of Current treatment for Triple-Negative Breast Cancer (TNBC)Wahyuni Wahyuni, Ajeng Diantini, Mohammad Ghozali, Idin Sahidin · 2022 · Research Journal of Pharmacy and Technology
- WGS Data Collections: How Do Genomic Databases Transform Medicine?Zbigniew J. Król, Paula Dobosz, Antonina Ślubowska, Magdalena Mroczek · 2023 · International Journal of Molecular Sciences
- The pharmacokinetics of pamiparib in the presence of a strong CYP3A inhibitor (itraconazole) and strong CYP3A inducer (rifampin) in patients with solid tumors: an open-label, parallel-group phase 1 studySong Mu, Chester Lin, Anna Skrzypczyk-Ostaszewicz, Iurie Bulat, Marina Maglakelidze, Viera Skarbová, Claudia Andreu‐Vieyra, Srikumar Sahasranaman · 2021 · Cancer Chemotherapy and Pharmacology
- Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid LeukemiaConstanze Schneider, Hermes Spaink, Gabriela Alexe, Neekesh V. Dharia, Ashleigh Meyer, Lucy A. Merickel, Delan Khalid, Sebastian Scheich, Björn Häupl, Louis M. Staudt et al. · 2024 · Cancer Research
- Olaparib: A tale of two dosage formsTrevor N. Christ · 2018 · Seminars in Oncology
- A systematic literature review assessing if genetic biomarkers are predictors for platinum-based chemotherapy response in ovarian cancer patientsCaitlin Phillips-Chavez, Michael Watson, Jermaine Ian George Coward, Janet Margaret Schloss · 2020 · European Journal of Clinical Pharmacology
- Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variantsKatherine E. Zarn, Sierra A. Jaramillo, Anthony R. Zapata, Nathan E. Stone, Ashley N. Jones, Haley E. Nunnally, Erik W. Settles, Ken Ng, Paul Keim, Steen Knudsen et al. · 2022 · PLoS ONE
- Identifying Biomarkers to Pair with Targeting Treatments within Triple Negative Breast Cancer for Improved Patient StratificationHolly Tovey, Maggie C.U. Cheang · 2019 · Cancers
- Phase Ib/II Study of Pamiparib Plus Radiation Therapy and/or Temozolomide in Adult Patients with Treatment-Naïve or Recurrent/Refractory GlioblastomaAnna F. Piotrowski, Kent C. Shih, Pierre Giglio, Howard Colman, Patrick Yung Wen, Jian Li Campian, Nicholas Arthur Butowski, Timothy Francis Cloughesy, Zhaoyin Zhu, Vitaliy Gisin et al. · 2025 · Current Oncology
- PARP10 is highly expressed and associated with inferior outcomes in acute myeloid leukemiaLing Wang, Chuang Jiang, Dandan Hu · 2023 · Aging
- Exploring the endogenous potential of Hemidesmus indicus against breast cancer using in silico studies and quantification of 2-hydroxy-4-methoxy benzaldehyde through RP-HPLCAkash Anand Bansod, R. Gnanam, Bharathi Nathan, Rajamani Kandhasamy, P Meenakshisundaram, V P Santhanakrishnan · 2021 · 3 Biotech
- Review of genetic and pharmacogenetic differences in cytotoxic and targeted therapies for pancreatic cancer in African AmericansGuettchina Telisnor, David L. DeRemer, Esther Frimpong, Edward Agyare, John M. Allen, Luisel J. Ricks‐Santi, Bo Han, Thomas J. George, Sherise Chantell Rogers · 2023 · Journal of the National Medical Association
- Targeted but Troubling: CYP450 Inhibition by Kinase and PARP Inhibitors and Its Clinical ImplicationsMartin Kondža, Josipa Bukić, Ivan Ćavar, Biljana Tubić · 2025 · Drugs and Drug Candidates
- Current and Future Trends in Neoadjuvant Immunotherapy for the Treatment of Triple-Negative Breast CancerRamon Andrade de Mello, Kátia Roque, Thaís Perez Vazquez · 2024 · Immunotherapy
- Hemodynamic Considerations in the Pathophysiology of Peripheral NeuropathyDaryl Irving Smith, Hai Thanh Tran, Joseph W. Poku · 2018 · InTech eBooks
- Circulating Tumor Cells and γH2AX As Biomarkers for Responsiveness to radium-223 in Advanced Prostate Cancer PatientsJonathan Alexander Chatzkel, Jesse Mocha, J. Joshua Smith, Junmin Zhou, Youngchul Kim, Ghassan E. El-Haddad, Jingsong Zhang · 2019 · Future Science OA
- Unravelling the molecular basis of PARP inhibitor resistance in prostate cancer with homologous recombination repair deficiencyNabila Zaman, Atar Singh Kushwah, Anagha Badriprasad, Goutam Chakraborty · 2024 · International review of cytology
- Clinical Impact of Somatic Genomic Testing on Breast Cancer CareTaha Khalid, Ramsey Cutress, Marcus Remer, Ellen Copson · 2024 · Clinical Oncology
- Recent Progress in Poly(ADP–Ribose) Polymerase‐1 Inhibitors for Application in CancerAnuradha Mehra, Shahnaz Islam, Rekha Sangwan · 2025 · ChemistrySelect
- ATR Inhibition Synergizes With Alkylating PI Polyamide Targeting MYCN by Suppressing DNA Repair in MYCN ‐Amplified NeuroblastomaXiaoyi Lai, Hiroyuki Yoda, Yuming Qiao, Yuki Kida, Keizo Takenaga, Yoshinao Shinozaki, Nobuko Koshikawa, Atsushi Takatori · 2025 · Cancer Science
- Development and External Validation of a Novel Model for Predicting Postsurgical Recurrence and Overall Survival After Cytoreductive R0 Resection of Epithelial Ovarian CancerQiaqia Li, Yinghong Deng, Wei Wei, Fan Yang, An Lin, Desheng Yao, Xiaofeng Zhu, Jundong Li · 2022 · Frontiers in Oncology
- [18F]F-Poly(ADP-Ribose) Polymerase Inhibitor Radiotracers for Imaging PARP Expression and Their Potential Clinical Applications in OncologyHonest Ndlovu, Ismaheel O. Lawal, Sipho Mdanda, Mankgopo Kgatle, Kgomotso M. G. Mokoala, Akram Al‐Ibraheem, Mike Machaba Sathekge · 2024 · Journal of Clinical Medicine
- First-Line Treatment with Olaparib for Early Stage BRCA-Positive Ovarian Cancer: May It Be Possible? Hypothesis Potentially Generating a Line of ResearchFederica Tomao, Serena Maria Boccia, Carolina Maria Sassu, Martina Chirra, Innocenza Palaia, Maria Cristina Petrella, Violante Di Donato, Nicoletta Colombo, Pierluigi Benedetti Panici · 2020 · Cancer Management and Research
- Recently approved treatment options for patients with metastatic triple-negative and HER2-neu-positive breast cancerSayed Reshad Ghafouri, Suvarna L Guvvala, Catherine Jones, Alexander V. Philipovskiy · 2022 · Journal of Investigative Medicine
- Targeting PD-1/PD-L1 in Biliary Tract Cancer: Role and Available DataReem D. Mahmood, Kathryn Graham, Jack Patrick Gleeson, Richard A Hubner, Juan W. Valle, Mairead Geraldine McNamara · 2023 · Immunotherapy
- Cancer Prevention Clinical Trials: Advances and ChallengesElizabeth R. Francis, Dr. Farzeen Syed, Arun Rajan, Eva M. Szabo · 2026 · Cancers
- International experience of using olaparib for metastatic castration-resistant prostate cancer: literature reviewVsevolod Borisovich Matveev, Oybek Khalmurzaev, О. I. Evsyukova · 2020 · Cancer Urology
- Effect of food on the pharmacokinetics and safety profiles of a new PARP inhibitor fuzuloparib capsules in healthy volunteersPengfei Du, Yao Long, Minhui Wang, Yunzhe Huang, Yaqin Wang, Xinyan Chen, Yuhong Lin, Jianbang Wu, Jie Shen, Yuanwei Jia · 2024 · Cancer Chemotherapy and Pharmacology
- PARP1 in melanoma: Mechanistic insights and implications for basic and clinical researchAndrea Marranci, Luisa Maresca, Samuele Lodovichi, Andrea Ghelli Luserna di Rorà, Barbara A. Stecca, Laura Poliseno · 2025 · Cancer Letters
- In silico study reveals unconventional interactions between MDC1 of DDR and Beclin-1 of autophagyKavya Ajit Pandya, Neeru Singh · 2022 · Molecular Diversity
- Incorporating functional genomics into the pathology-supported genetic testing framework implemented in South Africa: A future view of precision medicine for breast carcinomasClaudia Christowitz, Daniel Wilhelm Olivier, Johann W. Schneider, Maritha J. Kotze, Anna‐Mart Engelbrecht · 2024 · Mutation Research/Reviews in Mutation Research
- Assessing the benefits and safety profile of incorporating poly ADP-ribose polymerase (PARP) inhibitors in the treatment of advanced lung cancer: a thorough systematic review and meta-analysisMin Tang, Yue Wang, Pulin Li, Rui Han, Ran Wang · 2024 · Frontiers in Pharmacology
- DNA damage targeted therapy for advanced breast cancerVanessa Patel, Sandra Casimiro, Catarina Abreu, Tiago Barroso, Rita Sousa, Sofía Torres, Leonor Ribeiro, Gonçalo Nogueira-Costa, Helena Luna Pais, Conceição Pinto et al. · 2024 · Exploration of Targeted Anti-tumor Therapy
- AmNA ‐Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer‐Specific Chemosensitizer for Platinum CompoundsYuki Uchibori, Masaki Suekuni, Yuko Kokaji, Kazumasa Yoshida, Tohru Kiyono, Yuuya Kasahara, Masatoshi Fujita · 2025 · Cancer Science
- Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-outDanny Wilbie, Selma Eising, Vicky Amo-Addae, Johanna Walther, Esmeralda Bosman, Zhiyong Lei, Olivier G. de Jong, Jan J. Molenaar, Enrico Mastrobattista · 2025 · PLoS ONE
- The Current Landscape of PARP Inhibitors in Ovarian CancerCamille Catherine Gunderson, Britt Kristina Erickson, Megan E. Buechel, Kathleen N. Moore · 2018 · Current Obstetrics and Gynecology Reports
- Liquid chromatography-tandem mass spectrometry for pharmacokinetics evaluation of AZD5305, a selective PARP1 inhibitor, in miceGi Ju Lee, Jin Woo Kim, Hae-In Choi, Jin‐Young Choi, Kwan Hyung Cho, Tae‐Sung Koo · 2023 · Journal of Analytical Science & Technology
- Rates of genetic consultation in high‐grade serous ovarian cancer patients in the era of PARP inhibitor therapy: A population‐based studyShannon E. Brent, Jacob McGee, Danielle Vicus, Raymond H. Kim, Andrea F. Eisen, Andrew S. Wilton, Lilian Tran Gien · 2024 · International Journal of Gynecology & Obstetrics
- Unveiling the mechanistic roles of chlorine substituted phthalazinone-based compounds containing chlorophenyl moiety towards the differential inhibition of poly (ADP-ribose) polymerase-1 in the treatment of lung cancerFelix Oladele Okunlola, Fisayo Andrew Olotu, Mahmoud E. S. Soliman · 2021 · Journal of Biomolecular Structure and Dynamics
- Multimodality therapy in metastatic pancreas cancer with a BRCA mutation and durable long-term outcome: biology, intervention, or both?Thomas Lee Sutton, Aaron J. Grossberg, Frederick S. Ey, Eileen Mary O'Reilly, Brett C. Sheppard · 2021 · Cancer Biology & Therapy
- Patient-derived organoids and mini-PDX for predicting METN375S-mutated lung cancer patient clinical therapeutic responseMing Jiang, Rongfu Tu, Yiwen Pan, Yuxin Cui, Xin Qi, Hongyu Qin, Lijuan Liu, Xiaorui Wang, Ying Xue, Yao Xu et al. · 2024 · Heliyon
- Poly (ADP-ribose) polymerase inhibitor sensitized DNA damage caused by an alkylating pyrrole-imidazole polyamide targeting MYCN in neuroblastoma cellsXiaoyi Lai, Hiroyuki Yoda, Yuming Qiao, Yuki Kida, Keizo Takenaga, Yoshinao Shinozaki, Nobuko Koshikawa, Atsushi Takatori · 2024 · Biochemical and Biophysical Research Communications
- Treatment Options for Germline BRCA-Mutated Metastatic Pancreatic AdenocarcinomaDoreen Grzelak · 2021 · Journal of the Advanced Practitioner in Oncology
- Genetic variations affecting response of radiotherapyEun Kyung Choi · 2022 · Journal of genetic medicine
- Recent Advances, New Perspectives and Applications in the Treatment of Ovarian CancerMichael Friedrich · 2022 · IntechOpen eBooks
- Current Trends in the Treatment of Human Epidermal Growth Factor Receptor-2 Negative Breast CancerPalanisamy Sivanandy, Suresh Shanmugham, Rui Ying Lau, Jonathan Yvong Syen Chin, Xiao Xiang Lee, Yun Yun Lau, Wai Ching Lee, Iqbal Danial Said, Jing Ying Lee, Karthikayini Krishnasamy · 2020 · Journal of Pharmacy and Nutrition Sciences
- Influence of Residual Disease on the Efficacy of PARP Inhibitors in Advanced Epithelial Ovarian Cancer: A Systematic Review and Meta AnalysisSekyoung Hwang, Ji Hyun Kim, Uisuk Kim, Hyeong In Ha, S.-Y. Park, Myong Cheol Lim · 2025 · Cancers
- Elucidating the mechanisms of aristolochic acid-induced upper tract urothelial carcinoma: A multi-omics approach combining bioinformatics and computational modelingTongpeng Liu, Yu Yao, Yuan Xu, Haojun Zhang, Lijiang Sun, Guiming Zhang · 2026 · Computational Biology and Chemistry
- Hereditary Endometrial and Ovarian CancersGarima Yadav, Anshuja Singla · 2019 · Springer eBooks
- Routine Genetic Testing of Germline Breast Cancer Susceptibility ─ Challenges and OpportunitiesCornelia Leo, Kathrin Schwedler, Rosaria Condorelli, Nicole Bürki, Jens Huober, Khalil Zaman, Christian Kurzeder, Marcus Hermann Friedrich Vetter · 2023 · healthbook TIMES Oncology Hematology
- Genomic profiling of relapsed small cell lung cancer reveals potential pathways of therapeutic targetsWen Ouyang, Jing Yu, Zihang Zeng, Jun Gong, Junhong Zhang, Conghua Xie · 2023 · Journal of Thoracic Disease
- Current Trends in the Treatment of Human Epidermal Growth Factor Receptor-2 Negative Breast CancerPalanisamy Sivanandy, Suresh Shanmugam, Rui Ying Lau, Jonathan Yvong Syen Chin, Xiao Xiang Lee, Yun Yun Lau, Wai Ching Lee, Iqbal Danial Said, Jing Ying Lee, Karthikayini Krishnasamy · 2020 · Journal of Pharmacy and Nutrition Sciences
- The Important Role of Poly ADP-Ribose Polymerase Inhibitor in Prostate CancerJae Young Joung, Sung Han Kim · 2022 · Journal of Urologic Oncology
- PARP Inhibitors in the Treatment of Epithelial Ovarian CancerNicola Di Santo, Greta Bagnolini, Yin Wong, Marco Carnelli, Luigi Frigerio · 2022 · IntechOpen eBooks
- PARP Inhibitors in Breast Cancer: Latest EvidenceRyan M. Ponec, Parvin F. Peddi, Rena Desai Callahan · 2017 · Current Breast Cancer Reports
- DNA Mismatch Repair in Advanced Metastatic Prostate Carcinoma: Clinical PerspectiveAnju Bansal · 2017 · Journal of Cancer Prevention & Current Research
- Molecular Targeted Therapy for Epithelial Ovarian CancerHironori Tashiro, Hidetaka Katabuchi · 2018 · Springer eBooks
- Biological Modulation of Parp Inhibition in Triple Negative Breast Cancer, a Combinational Approach Implementing Multitargeted Epigenetic Therapy (Mtet) with Parp Inhibition, in Advanced Breast Cancer: A Case StudyMohammad Amin Nezami, Steve Hager, Julie Taguchi · 2018 · Journal of Cancer Therapy
- Olaparib: A Tale of Two Dosage FormsTrevor N. Christ · 2018 · Cancer therapy & Oncology International Journal
- Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerase (PARP), blocks replication of the SARS-CoV-2 human coronavirus in vitroNathan E. Stone, Sierra A. Jaramillo, Ashley N. Jones, Adam J. Vazquez, Madison Martz, Lora M. Versluis, Marlee O. Raniere, Haley E. Nunnally, Katherine E. Zarn, Roxanne D. Nottingham et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- The effect of nucleic acid-binding ligands on CTG/CAG repeat DNA metabolism in vitroKaren Chiang · 2018 · TSpace (University of Toronto)
- Prevalence of tumor genomic alternations in homologous recombination genes among Taiwanese breast cancersChi‐Cheng Huang, Chun‐Yu Liu, Yi‐Fang Tsai, Pei‐Ju Lien, Yen‐Shu Lin, Ta‐Chung Chao, Chin-Jung Feng, Yen-Jen Chen, Jiun‐I Lai, Nam Nhut Phan et al. · 2021 · Research Square
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- Data from Pamiparib Monotherapy for Patients with Germline BRCA1/2-Mutated Ovarian Cancer Previously Treated with at Least Two Lines of Chemotherapy: A Multicenter, Open-Label, Phase II StudyXiaohua Wu, Jianqing Zhu, Jing Wang, Zhongqiu Lin, Rutie Yin, Wei Sun, Qi Zhou, Songling Zhang, Danbo Wang, Hong Shi et al. · 2023
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