The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Investigation of joint hypermobility in individuals with hyperbilirubinemia
Open accessAbstract
Abstract Objective: Benign joint hypermobility syndrome refers to hypermobile individuals with musculoskeletal symptoms in the absence of any systemic rheumatic disease; its prevalence is approximately 0.5%. In animal studies, bilirubin has been shown to reduce fibrosis induced by bleomycin. It has been suggested that bilirubin leads to hypermobility that affects the structure or function of collagen. In addition, our observation is that hypermobility occurs more often in patients with indirect hyperbilirubinemia. In this study, we aimed to evaluate hypermobility in patients with indirect hyperbilirubinemia. Material and Methods: We recruited 120 consecutive patients with indirect hyperbilirubinemia from a tertiary gastroenterology outpatient clinic and examined them for hypermobility. Hypermobility was evaluated using the Beighton criteria, and other relevant clinical findings were recorded. In addition, a group of healthy individuals (n=107) without hyperbilirubinemia were included as controls. Results: The mean ages of the patients and controls were 33.4±12.9 and 36.2±11.2 years, respectively (p=0.09). In total, 100 (83%) patients and 78 (73%) controls were male (p=0.075). The mean indirect bilirubin levels were 1.44±0.66 mg/dL in the patient group and 0.37±0.18 mg/dL in the control group. Based on the Beighton score, 23 patients (19.2%) in the patient group and 3 (2.8%) individuals in the control group had joint hypermobility. The difference between the groups was statistically significant (p<0.001). Conclusion: According to the results of our study, findings of joint hypermobility are more frequent in patients with indirect hyperbilirubinemia than in controls.
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“One case–control study conducted from a rheumatology clinic reported an association between unconjugated hyperbilirubinemia from Gilbert's syndrome and hypermobile joints. 39”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [39]
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Cites
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
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Collagens—structure, function, and biosynthesis
Gelse, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.08.002 · Cited by 2,777
Articular mobility in an African population.
Beighton, P., Solomon, L., & Soskolne, C. L. (1973) · Annals of the Rheumatic Diseases · doi:10.1136/ard.32.5.413 · Cited by 1,727
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PERSISTENT JOINT LAXITY AND CONGENITAL DISLOCATION OF THE HIP
Carter, C., & Wilkinson, J. (1964) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.46b1.40 · Cited by 590
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Dysautonomia in the joint hypermobility syndrome
Gazit, Y., Nahir, A. M., Grahame, R., & Jacob, G. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00235-3 · Cited by 390
Phillips, C. L., Combs, S. B., & Pinnell, S. R. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12393187 · Cited by 202
Chronic pain is a manifestation of the Ehlers-Danlos syndrome
Sacheti, A., Szemere, J., Bernstein, B., Tafas, T., Schechter, N. L., & Tsipouras, P. (1997) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(97)00007-9 · Cited by 191
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Thwaites, P. A., Gibson, P. R., & Burgell, R. E. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15927 · Cited by 59
Metadata
- Authors
- Çınar, M., Çakar, M., Öztürk, K., Çetindağlı, İ., Yılmaz, S., & Dinç, A.
- Affiliations
- Gülhane Eğitim ve Araştırma Hastanesi (TR)
- Venue
- European Journal of Rheumatology
- Publisher
- AVES YAYINCILIK A.Ş.
- Published
- 2019-09-03
- Volume
- 4
- Issue
- 1
- Pages
- 36-39
- ISSN
- 2147-9720 (ISSN-L)
- 2148-4279
- PMC
- PMC5335885
- OpenAlex
- W2593437759
- Cited by
- 1
- References
- 22
- Citations by year
- 2022: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- European Journal of Rheumatology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Keywords
- joint hypermobility, benign joint hypermobility syndrome, unconjugated hyperbilirubinemia, bilirubin, Beighton score, collagen, fibrosis, musculoskeletal symptoms
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