Blood Count Parameters as Inflammation Indicators in Children and Adolescents Diagnosed with Depressive Disorder
Open accessAbstract
Aim: There is increasing evidence that immunological and inflammatory dysfunctions play an essential role in the initiation and progression of major psychiatric disorders. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume can be used as markers of systemic inflammation in different diseases. We aimed to investigate these blood count parameters in children and adolescents diagnosed with major depressive disorder. Methods: diagnostic criteria, and healthy children and adolescents matched at a ratio of 1 to 2. Data of 58 cases and 90 healthy controls evaluated between 01.07.2019 and 01.07.2020 were included. Results: Platelet-to-lymphocyte ratio values were significantly higher in the case group. No significant difference was found between patient and control groups regarding other blood count parameters. When depression group was compared in terms of all parameters as those who committed suicide and those did not, significant difference was found between the 3 groups in terms of platelet-to-lymphocyte ratio values. The intergroup difference in platelet-to-lymphocyte ratio was found between the depression group without suicide and the control group. No significant relationship was found between other parameters and Children's Depression Inventory Scale scores. We determined a cut-off value of 112.5 for platelet-to-lymphocyte ratio (with sensitivity of 70% and specificity of 63%). Conclusion: Platelet-to-lymphocyte ratio might be an important parameter in the clinical follow-up of major depressive disorder.
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Five included studies were conducted in Turkey, one in India, two in Spain, one in Sweden, one in Israel, and one in Thailand.
“Five studies were conducted in Turkey [8, 20, 30–32], one in India [27], two in Spain [4, 29], one in Sweden [28], one in Israel [26], and one in Thailand [9].”
Three other studies reported no statistically significant differences in NLR between depressed patients with a history of SA and HC.
“However, three other studies reported no statistically significant differences [28, 29, 31] (Table 3).”
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References 27 · Cited by 13
Research works printed but not linked: 2
- [1]Mazza MG Rossetti A Clerici MA. Review of neutrophil-lymphocyte, monocyte-lymphocyte, and platelet-lymphocyte ratios use in psychiatric disorders. World J Depress Anxiety. 2018; 1(1):1002.
- [14]Öy B Child depression inventory Turkish adaptation: a validity and reliability study. Turk Psikiyatr Derg. 1991; 2: 132 136.
- Authors
- Child and Adolescent Psychiatry, U. O. H. S., Önen, Ö., Erkuran, H. Ö., Child and Adolescent Psychiatry, U. O. H. S., Bağ, Ö., Department of Social Pediatrics, U. O. H. S., Abacıgil, F., & Department of Public Health, A. A. M. U. F. O. M.
- Affiliations
- Dr. Behçet Uz Çocuk Hastalıkları Hastanesi (TR)
- Adnan Menderes University (TR)
- Corresponding author
- Önen, Özlem
- Venue
- Psychiatry and Clinical Psychopharmacology
- Publisher
- Taylor & Francis
- Published
- 2021-12-23
- Volume
- 31
- Issue
- 4
- Pages
- 425-433
- ISSN
- 2475-0573 (ISSN-L)
- PMC
- PMC11079696
- OpenAlex
- W4200103417
- Cited by
- 13
- References
- 27
- Citations by year
- 2025: 8 · 2024: 3 · 2023: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Psychiatry and Clinical Psychopharmacology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, mean platelet volume, systemic inflammation, inflammatory markers, children and adolescents, suicide, Children's Depression Inventory, cut-off values
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