The DOI matches its Crossref record.
Role of Th1/Th2 cells and related cytokines in autoimmune hepatitis
Abstract
Background/aims Dysregulation of T cell response is thought to play an important role in the immunopathogenesis of autoimmune hepatitis. However, no consensus has yet been reached regarding the implications of a distinct T cell subset in the pathogenesis of this progressive liver disease. Therefore, T-bet and GATA-3 expression was examined in patients with autoimmune hepatitis (AIH) and in healthy controls. Moreover, the profile of Th1 (IFN-γ) and Th2 (IL-4) cytokine gene expression was analyzed. Materials and methods Levels of mRNA transcripts were measured in peripheral blood mononuclear cells (PBMCs) using a two-step reverse transcription quantitative real-time polymerase chain reaction with SYBR Green. Results T-bet and IFN-γ mRNA expression was significantly higher in AIH patients compared to healthy controls (p 0.05). Conclusion Alterations in the Th1/Th2 cell balance may be responsible for both disease progression and the resulting complications.
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“levels of this molecule alongside Tbet are increased in patients with untreated AIH (367).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [367]
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The liver as a central "hub" of the immune system: pathophysiological implications
Ronca, V., Gerussi, A., Collins, P., Parente, A., Oo, Y. H., & Invernizzi, P. (2025) · Physiological Reviews · doi:10.1152/physrev.00004.2023 · Cited by 59
Metadata
- Authors
- Behfarjam, F., Sanati, M. H., Nasseri Moghaddam, S., Ataei, M., Nikfam, S., & Jadali, Z.
- Affiliations
- National Institute of Genetic Engineering and Biotechnology (IR)
- Venue
- The Turkish Journal of Gastroenterology
- Publisher
- AVES YAYINCILIK A.Ş.
- Published
- 2017-03-03
- Volume
- 28
- Issue
- 2
- Pages
- 110-114
- ISSN
- 1300-4948 (ISSN-L)
- 2148-5607
- OpenAlex
- W2580258789
- Cited by
- 26
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 2 · 2019: 2 · 2018: 7 · 2017: 1
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Turkish Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Rheumatology › IgG4-Related and Inflammatory Diseases
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- autoimmune hepatitis, Th1/Th2 balance, T-bet, GATA3, interferon-gamma, IL-4, cytokine gene expression, T cell dysregulation, immunopathogenesis, peripheral blood mononuclear cells
- MeSH terms
- Adult, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, RNA, Messenger, Interleukin-4, Case-Control Studies, Th1 Cells, Th2 Cells, Hepatitis, Autoimmune, GATA3 Transcription Factor, Th1-Th2 Balance, Real-Time Polymerase Chain Reaction
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