Ca2+- and CaMKII-mediated processes in early LTP
Open accessAbstract
Learning methods determine the degree of stimulation of engrams encoding information to be memorised. More enriching modes of learning allow more enduring long-term potentiation of the synapses associated with these memories. The additional activity causes a prolonged increase in [Ca2+] in the dendritic spine of the postsynaptic neuron. This allows Ca(2+)-mediated molecular pathways to bring about cytoskeletal remodeling, posttranslational modifications, and protein trafficking. These processes contribute to early long-term potentiation of the synapses, strengthening the memory they store and lead to improved performance on tests of memory recall.
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Enriched learning modes elevate intracellular calcium levels, promoting CaMKII-mediated cytoskeletal remodeling to strengthen stored memories.
“Furthermore, enriched learning modes elevate intracellular calcium levels, promoting CaMKII-mediated cytoskeletal remodeling to strengthen stored memories [66].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [66]
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Cites
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003 · see citing works
Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation
Bosch, M., Castro, J., Saneyoshi, T., Matsuno, H., Sur, M., & Hayashi, Y. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.021 · Cited by 637 · see citing works
Kalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines
Xie, Z., Srivastava, D. P., Photowala, H., Kai, L., Cahill, M. E., Woolfrey, K. M., Shum, C. Y., Surmeier, D. J., & Penzes, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.005 · Cited by 373 · see citing works
Okamoto, K.-I., Narayanan, R., Lee, S. H., Murata, K., & Hayashi, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701656104 · Cited by 328 · see citing works
Shifman, J. M., Choi, M. H., Mihalas, S., Mayo, S. L., & Kennedy, M. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606433103 · Cited by 143 · see citing works
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Research works printed but not linked: 20
- [1]Vickers CA Wyllie DJ Late-phase, protein synthesis-dependent long-term potentiation in hippocampal CA1 pyramidal neurones with destabilized microtubule networks. Br J Pharmacol 2007 151 7 1071 1077 17549044 PMC2042922
- [3]Lench AM Massey PV Pollegioni L Astroglial d-serine is the endogenous co-agonist at the presynaptic NMDA receptor in rat entorhinal cortex. Neuropharmacology 2014 83C 118 127 24747728
- [4]Panatier A Theodosis DT Mothet JP Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell 2006 125 4 775 784 16713567
- [5]Okamoto K Bosch M Hayashi Y The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag? Physiology (Bethesda) 2009 24 357 366 19996366
- [6]Zhang YP Holbro N Oertner TG Optical induction of plasticity at single synapses reveals input-specific accumulation of alphaCaMKII. Proc Natl Acad Sci USA 2008 105 33 12039 12044 18697934 PMC2575337
- [7]Lisman J Schulman H Cline H The molecular basis of CaMKII function in synaptic and behavioural memory. Nat Rev Neurosci 2002 3 3 175 190 11994750
- [8]Stratton M Lee IH Bhattacharyya M Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity. Elife 2014 3 PMC3901001 24473075
- [11]Tashiro A Minden A Yuste R Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and Rho. Cereb Cortex 2000 10 10 927 938 11007543
- [13]Boron WF Boulpaep EL (2012). Medical physiology a cellular and molecular approach (Updated second edition. ed.)
- [14]Lussier MP Gu X Lu W Casein kinase 2 phosphorylates GluA1 and regulates its surface expression. Eur J Neurosci 2014 39 7 1148 1158 24712994 PMC4002167
- [15]Kristensen AS Jenkins MA Banke TG Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating. Nat Neurosci 2011 14 6 727 735 21516102 PMC3102786
- [16]Huganir RL Nicoll R A AMPARs and synaptic plasticity: the last 25 years. Neuron 2013 80 3 704 717 24183021 PMC4195488
- [17]Opazo P Labrecque S Tigaret CM CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin. Neuron 2010 67 2 239 252 20670832
- [18]Petrini E M Lu J Cognet L Endocytic trafficking and recycling maintain a pool of mobile surface AMPA receptors required for synaptic potentiation. Neuron 2009 63 1 92 105 19607795 PMC2847611
- [19]Park M Salgado J M Ostroff L Plasticity- induced growth of dendritic spines by exocytic trafficking from recycling endosomes. Neuron 2006 52 5 817 830 17145503 PMC1899130
- [20]Schafer JC Baetz NW Lapierre LA Rab11- FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles. Traffic 2014 15 3 292 308 24372966 PMC4081500
- [21]Wang Z Edwards JG Riley N Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Cell 2008 135 3 535 548 18984164 PMC2585749
- [22]Sabatini BL Oertner TG Svoboda K The life cycle of Ca(2+) ions in dendritic spines. Neuron 2002 33 3 439 452 11832230
- [23]Zanassi P Paolillo M Feliciello A cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons. J Biol Chem 2001 276 15 11487 11495 11139572
- [24]Coultrap SJ Freund RK O’Leary H Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection. Cell Rep 2014 6 3 431 437 24485660 PMC3930569
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Molecular Physiology of the Neuronal Synapse
Ramírez-Expósito, M. J., Cueto-Ureña, C., & Martínez-Martos, J. M. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48010088 · Cited by 6 · see citing works
- Authors
- Byth, L. A.
- Affiliations
- Griffith University (AU)
- Corresponding author
- Byth, Lachlan A
- ORCID
- Byth, Lachlan A
- Venue
- Annals of Neurosciences
- Publisher
- SAGE Publications
- Published
- 2014-10-01
- Volume
- 21
- Issue
- 4
- Pages
- 151-3
- ISSN
- 0972-7531 (ISSN-L)
- 0976-3260
- PMC
- PMC4248478
- OpenAlex
- W2046133268
- Cited by
- 18
- References
- 5
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 3
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-nd
- Locations
- Annals of Neurosciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- long-term potentiation, CaMKII, calcium signaling, dendritic spines, synaptic plasticity, memory encoding, cytoskeletal remodeling, post-translational modification, protein trafficking, memory retrieval
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