The DOI matches its DataCite record.
Anti-Aging Effects Of Retinol And Alpha Hydroxy Acid On Elastin Fibers Of Artificially Photo-Aged Human Dermal Fibroblast Cell Lines
Open accessAbstract
Skin aging is a slow multifactorial process influenced by both internal as well as external factors. Ultra-violet radiations (UV), diet, smoking and personal habits are the most common environmental factors that affect skin aging. Fat contents and fibrous proteins as collagen and elastin are core internal structural components. The direct influence of UV on elastin integrity and health is central on aging of skin especially by time. The deposition of abnormal elastic material is a major marker in a photo-aged skin. Searching for compounds that may protect against cutaneous photodamage is exceedingly valued. Retinoids and alpha hydroxy acids have been endorsed by some researchers as possible candidates for protecting and or repairing the effect of UV damaged skin. For consolidating a better system of anti- and protective effects of such anti-aging agents, we evaluated the combinatory effects of various dosages of lactic acid and retinol on the dermal fibroblast’s elastin levels exposed to UV. The UV exposed cells showed significant reduction in the elastin levels. A combination of drugs with a higher concentration of lactic acid (30 -35 mM) and a lower concentration of retinol (10-15mg/mL) showed to work better in maintaining elastin concentration in UV exposed cells. We assume this preservation could be the result of increased tropo-elastin gene expression stimulated by retinol whereas lactic acid probably repaired the UV irradiated damage by enhancing the amount and integrity of the elastin fibers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“It is proposed to increase elastin protein levels and elastin fibres density in cultured dermal fibroblasts [17].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [17]
The cited source says what the claim attributes to it.
In the citing paper
“Moreover, it is known that rays from sunlight account for the majority of the symptoms of premature skin ageing so the simple fact of using products that prevent sun exposure and its effects already indicate that it is a way to avoid skin photoageing [17].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Still being checked.
Research works printed but not linked: 7
- A. Hayashi, T. Suzuki, and S. Tajima, "Modulations of elastin expression and cell proliferation by retinoids in cultured vascular smooth muscle cells," J. Biochem., vol. 117, pp. 132-136G. Jan 1995.
- J. William, B. Timothy, "Diseases of the Skin: clinical Dermatology", Saunders Elsevier. ISBN 0-7216-2921-0, 2006.
- L. D. Muiznieks, A. S. Weiss and F.W. Keeley, "Structural disorder and dynamics of elastin", Biochem Cell Biol 88 (2): 239-50, 2010.
- G. A. Di Lullo, S. M. Sweeney, J. Körkkö, L. Ala-Kokko, J. D. San Antonio, "Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen", J. Biol. Chem. 277 (6): 4223-4231, 2002.
- M. Ramos, E. Silva, D. M. Hexsel, M. S. Rutowitsch, "Hydroxy acids and retinoids in cosmetics, "ClinDermatol; 19:460-6, 2001.
- X. Wang. "A theory for the mechanism of action of the alpha-hydroxy acids applied to the skin", Medical Hypotheses; 53:120 -2, 1999.
- M. N. O'Donoghue. "Update on acne therapy". Dermatol Nurs; 11:205- 8, 1999.
Cited by
Sorted by citations
Elastin structure and its involvement in skin photoageing
Weihermann, A. C., Lorencini, M., Brohem, C. A., & de Carvalho, C. M. (2017) · International Journal of Cosmetic Science · doi:10.1111/ics.12372 · Cited by 195
Natural anti-aging skincare: role and potential
Ahmed, I. A., Mikail, M. A., Zamakshshari, N. H., & Abdullah, A.-S. H. (2020) · Biogerontology · doi:10.1007/s10522-020-09865-z · Cited by 188
Xiao, Y., Zhou, L. Y., Hao, H., Bao, Y., Yin, Q., & Xie, C. (2021) · Crystal Growth & Design · doi:10.1021/acs.cgd.0c01519 · Cited by 61
Zhong, J., Zhao, N., Song, Q., Du, Z., & Shu, P. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16415 · Cited by 65
Lee, H., Lee, S., Kyung, S., Ryu, J., Kang, S., Park, M., & Lee, C.-H. (2021) · Metabolites · doi:10.3390/metabo11080524 · Cited by 26
Metadata
- Authors
- Jarrar, M., Behl, S., Shaheen, N., Fatima, A., & Nasab, R.
- ORCID
- Venue
- Zenodo
- Publisher
- Zenodo
- Published
- 2015-03-05
- OpenAlex
- W1513798627
- Cited by
- 5
- References
- 0
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 1 · 2016: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- Zenodo (CERN European Organization for Nuclear Research) (cc-by)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- skin aging, photoaging, retinol, α-hydroxy acids, lactic acid, elastin, dermal fibroblasts, ultraviolet radiation, combination therapy, anti-aging agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
