Breed Susceptibility for Developmental Orthopedic Diseases in Dogs
Abstract
A large-scale epidemiological study was conducted to determine breeds at risk for 12 developmental orthopedic diseases (DODs). Developmental orthopedic diseases investigated included canine hip dysplasia (CHD); craniomandibular osteopathy (CMO); fragmented coronoid process; hypertrophic osteodystrophy; Legg-Calvé-Perthes disease; osteochondrosis of the medial humeral condyle, caudal humeral head, femoral condyles, and talar trochlear ridges; panosteitis; patella luxation; and ununited anconeal process. Dogs that were diagnosed with any one of the diseases of interest at any of 10 veterinary teaching hospitals participating in the Veterinary Medical Database from 1986 to 1995 were included as cases. Odds ratios and corresponding 95% confidence intervals were calculated to determine risk. Frequency of diagnosis during the 10-year period ranged from 35 cases (CMO) to 10,637 cases (CHD). The number of breeds at increased risk for a disease ranged from one (CMO) to 35 (CHD). Breed susceptibility for a DOD may suggest a genetic component in the disease etiology. The results of this study serve to increase veterinarians’ awareness of breeds susceptible to DODs and may facilitate the control of such diseases by identifying breeds that might benefit from breeding programs or environmental intervention such as dietary modification.
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Inbreeding increases hereditary pathology and conformational disorders, such as orthopaedic and joint disorders, skin disease, aural disease, ocular disease, or breathing difficulties like brachycephalic obstructive airway syndrome.
“And in many cases, this also increases hereditary pathology and conformational disorders, such us orthopaedic and joint disorders [26,184,185]; skin disease [26]; aural disease [186]; ocular disease [121,187]; or even breathing difficulties, like the sadly famous brachycephalic obstructive airway syndrome (BOAS) [121,188,189].”
From Ethical Concerns about Fashionable Dog Breeding (2024) · cites this paper as [185]
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References 32 · Cited by 267
- Authors
- LaFond, E., Breur, G. J., & Austin, C. C.
- Affiliations
- Purdue University West Lafayette (US)
- Venue
- Journal of the American Animal Hospital Association
- Publisher
- American Animal Hospital Association
- Published
- 2002-09
- Volume
- 38
- Issue
- 5
- Pages
- 467-477
- ISSN
- 0587-2871 (ISSN-L)
- 1547-3317
- OpenAlex
- W2160639616
- Cited by
- 267
- References
- 32
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 21 · 2023: 18 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 14 · 2018: 15 · 2017: 11 · 2016: 13 · 2015: 13 · 2014: 15 · 2013: 12 · 2012: 16
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Animal Hospital Association (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- Topics
- Health Sciences › Veterinary › Small Animals › Veterinary Orthopedics and Neurology
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Keywords
- developmental orthopedic disease, dogs, breed susceptibility, canine hip dysplasia, hypertrophic osteodystrophy, Legg-Calvé-Perthes disease, osteochondrosis, ununited anconeal process, genetic susceptibility, disease risk factors
- MeSH terms
- Animals, Bone Diseases, Developmental, Breeding, Dog Diseases, Dogs, Female, Hip Dysplasia, Canine, Indiana, Male, Records, Retrospective Studies, Risk Factors, Odds Ratio, Genetic Predisposition to Disease
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