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Role of Myo-inositol and D-Chiro-Inositol in Improvement of Endocrine and Clinical Parameters in Girls affected by PCOS
Open accessAbstract
Aim: To evaluate the effectiveness of Myo-inositol and D-chiro-Inositol combination therapy in improvement of Endocrine and clinical parameters in teenage girls affected by PCOS. Methods: This Prospective Cohort study was conducted in the Department of Gynaecology & Obstetrics, Avicenna Medical College and hospital after approval from Institutional ethical committee from January 2021 to June 2021. We have enrolled 106 teenage girls from 13 to 19 years with PCOS. Baseline clinical, ultrasound and biochemical parameters were noted and assigned them into two treatment groups (A & B) randomly. Group A was given MI plus DCI and Group B was given placebo for 6 months. Differences were analyzed in pretreatment and post treatment ultrasound findings and Clinical variable of BMI, Acne, hirsutism and menstrual irregularities. Biochemical parameters including LH:FSH ratio, 17-beta Estradiol and fasting glucose were also evaluated in both groups. Statistical Analysis was done using SPSS version 21. Results: A statistically significant improvement was observed in clinical & Laboratory parameters in treatment group showing reduced LH:FSH ratio, fasting glucose and increased Estradiol levels along with decreased BMI, Acne and hair growth and improved ultrasound parameters in same group as compared to placebo group. Conclusion: The current study showed promising results of combined therapy with MI plus DCI for treatment and improvement of clinical and lab parameters in teenage girls affected with PCOs as compared to placebo. Keywords: PCOS, Myo-inositol, D-chiro-inositol, Hirsutism, Acne.
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“Another study (n = 106) (37) compared 500 mg MI in combination with 13.8 mg DCI twice daily for 6 months to FA among a population of teenage girls (age 13-19 years) with PCOS. This study had high risk of bias and reported no significant difference in fasting glucose between intervention and placebo group. There was a significant reduction in number of participants with elevated BMI in the”
From Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines (2024) · cites this paper as [37]
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“There was 1 study including only adolescents (n = 106) (37).”
From Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines (2024) · cites this paper as [37]
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“Three compared the combination of 550 mg MI + 13.8 mg DCI + 200 mcg FA twice daily to FA alone (29, 37, 38).”
From Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines (2024) · cites this paper as [37]
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“Ten used FA at doses ranging from 200 to 400 mcg daily (25, 27, 29, 31, 34, 37, 46-49).”
From Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines (2024) · cites this paper as [37]
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Citations
Cites
Poly Cystic Ovarian Syndrome: An Updated Overview
Hayek, S. E., Bitar, L., Hamdar, L., Mirza, F., & Daoud, G. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00124 · Cited by 342
Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials
Unfer, V., Facchinetti, F., Orrù, B., Giordani, B., & Nestler, J. E. (2017) · Endocrine Connections · doi:10.1530/ec-17-0243 · Cited by 220
Sidra, S., Tariq, M. H., Farrukh, M. J., & Mohsin, M. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223329 · Cited by 112
Benelli, E., Del Ghianda, S., Di Cosmo, C., & Tonacchera, M. (2016) · International Journal of Endocrinology · doi:10.1155/2016/3204083 · Cited by 100
Kamenov, Z., & Gateva, A. (2020) · Molecules · doi:10.3390/molecules25235566 · Cited by 100
CONCERN: Does ovary need D-chiro-inositol?
Isabella, R., & Raffone, E. (2012) · Journal of Ovarian Research · doi:10.1186/1757-2215-5-14 · Cited by 67
Inositols’ Importance in the Improvement of the Endocrine–Metabolic Profile in PCOS
Wojciechowska, A., Osowski, A., Jóźwik, M., Górecki, R. J., Rynkiewicz, A., & Wojtkiewicz, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225787 · Cited by 64
Myo-Inositol in the Treatment of Teenagers Affected by PCOS
Pkhaladze, L., Barbakadze, L., & Kvashilava, N. (2016) · International Journal of Endocrinology · doi:10.1155/2016/1473612 · Cited by 62
Minozzi, M., Nordio, M., & Pajalich, R. (2013) · PubMed · Cited by 61
Saleem, F., & Rizvi, S. W. (2017) · Cureus · doi:10.7759/cureus.1844 · Cited by 56
Gateva, A., Unfer, V., & Kamenov, Z. A. (2018) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1421632 · Cited by 51
Altered Ovarian Inositol Ratios May Account for Pathological Steroidogenesis in PCOS
Unfer, V., Dinicola, S., Laganà, A. S., & Bizzarri, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197157 · Cited by 51
Polycystic Ovary Syndrome: Insights into the Therapeutic Approach with Inositols
Sortino, M. A., Salomone, S., Carruba, M. O., & Drago, F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00341 · Cited by 50
Troisi, J., Cinque, C., Giugliano, L., Symes, S. J. K., Richards, S. M., Adair, D. C., Cavallo, P., Sarno, L., Scala, G., Caiazza, M., et al. (2019) · Journal of Ovarian Research · doi:10.1186/s13048-019-0500-x · Cited by 30
Davinelli, S., Nicolosi, D., Cesare, C. D., Scapagnini, G., & Marco, R. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9040987 · Cited by 23
Anjum, S., Askari, S., Riaz, M., & Basit, A. (2020) · Cureus · doi:10.7759/cureus.11860 · Cited by 19
Ranwa, M., Nagaria, T., Jaiswal, J., & Arya, A. K. (2017) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20172120 · Cited by 7
Sangeereni, M., & Duraisingam, A. (2020) · International Journal of Clinical Obstetrics and Gynaecology · doi:10.33545/gynae.2020.v4.i6b.737 · Cited by 3
Cited by
Sorted by citations
Fitz, V., Graca, S., Mahalingaiah, S., Liu, J., Lai, L., Butt, A., Armour, M., Rao, V., Naidoo, D., Maunder, A., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad762 · Cited by 70
Myoinositol or D-chiro-inositol for PCOS symptoms in adolescents: a narrative review
Sairally, B. Z. F., Dhillon‐Smith, R. K., Jethwani, G., & Latthe, P. M. (2023) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2023-0458 · Cited by 6
Metadata
- Authors
- Khan, R. B., Sarosh, M., & Anwer, S.
- Affiliations
- Avicenna Medical College (PK)
- Bahawal Victoria Hospital (PK)
- Venue
- Pakistan Journal of Medical and Health Sciences
- Publisher
- Lahore Medical and Dental College
- Published
- 2022-01-16
- Volume
- 16
- Issue
- 1
- Pages
- 21-24
- ISSN
- 1996-7195 (ISSN-L)
- OpenAlex
- W4206580320
- Cited by
- 2
- References
- 18
- Citations by year
- 2023: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Pakistan Journal of Medical and Health Sciences (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Keywords
- polycystic ovary syndrome, myo-inositol, D-chiro-inositol, combination therapy, adolescent girls, hirsutism, acne, menstrual irregularity, LH/FSH ratio, estradiol, fasting blood glucose, body mass index
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