CoChat
Sign Up
Cited by 54Diabetes and associated disordersDiabetes Management and ResearchAdrenal Hormones and Disorders

Characteristics and Prevalence of Latent Autoimmune Diabetes in Adults (LADA)

Open access
Brahmkshatriya, Priyanka P., Mehta, Anita A., Saboo, Banshi D., Goyal, Ramesh K.·2012·ISRN Pharmacology
DOI 10.5402/2012/580202PMC PMC3339117
Open this paper in CoChat — free accountOpen PDF

Abstract

Diabetes, one of the most commonly seen metabolic disorders, is affecting a major area of population in many developing as well as most of the developed countries and is becoming an alarming concern for the rising cost of the healthcare system. Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is less recognized and underdiagnosed type of diabetes which appears to have characteristics of both type 1(autoimmune in nature) and type 2 diabetes(adult age at onset and initial response to oral hypoglycemic agents). An epidemiological study was carried out on 500 patients in the western region of India. Various parameters such as age at onset, duration of diabetes, gender, basal metabolic index (BMI), type of diabetes, family history, HbA1c levels, cholesterol levels, and current treatment regimen were evaluated and correlated with type 1 and type 2 diabetes.Moreover, diagnostic markers for LADA, namely, GAD autoantibodies and C-peptide levels, were determined for 80 patients selected from the epidemiological study. Some of the results obtained were found to be consistent with the literature whereas some results were found to be contradictory to the existing data.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.5402/2012/580202

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In an Indian study, the average age at diabetes mellitus onset in those with LADA was 33.4 years, significantly lower than in those with T2DM at 48.0 years.

    “An Indian study found that the average age at diabetes mellitus onset in those with LADA (33.4 years) was significantly lower than in those with T2DM (48.0 years)82.”

    From The epidemiology of type 1 diabetes mellitus in older adults (2025) · cites this paper as [82]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 26

  1. [1]Diamond JM Diabetes running wild Nature 1992 357 6377 362 363 1594040
  2. [2]Zimmet PZ The pathogenesis and prevention of diabetes in adults: genes, autoimmunity, and demography Diabetes Care 1995 18 7 1050 1064 7555542
  3. [4]Isomaa B Almgren P Henricsson M Chronic complications in patients with slowly progressing autoimmune type 1 diabetes (LADA) Diabetes Care 1999 22 8 1347 1353 10480781
  4. [6]Zimmet P Turner R McCarty D Rowley M Mackay I Crucial points at diagnosis: type 2 diabetes or slow type 1 diabetes Diabetes Care 1999 22 supplement 2 B59 B64 10097901
  5. [7]Pozzilli P Di Mario U Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes off the adult): definition, characterization, and potential prevention Diabetes Care 2001 24 8 1460 1467 11473087
  6. [8]Falorni A Calcinaro F Autoantibody profile and epitope mapping in latent autoimmune diabetes in adults Annals of the New York Academy of Sciences 2002 958 99 106 12021088
  7. [9]Landin-Olsson M Latent autoimmune diabetes in adults Annals of the New York Academy of Sciences 2002 958 112 116 12021090
  8. [11]Carlsson S Midthjell K Grill V Influence of family history of diabetes on incidence and prevalence of latent autoimmune diabetes of the adult: results from the Nord-Trøndelag health study Diabetes Care 2007 30 12 3040 3045 17878245
  9. [12]Alberti KG Zimmet PZ Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation Diabetic Medicine 1998 15 7 539 553 9686693
  10. [13]Scarlett JA Mako ME Rubenstein AH Factitious hypoglycemia. Diagnosis by measurement of serum C-peptide immunoreactivity and insulin-binding antibodies The New England Journal of Medicine 1977 297 19 1029 1032 198659
  11. [14]Clare-Salzler MJ Tobin AJ Kaufman DLO Glutamate decarboxylase: an autoantigen in IDDM Diabetes Care 1992 15 1 132 135 1737532 PMC8223701
  12. [15]Wild S Roglic G Green A Sicree R King H Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 2004 27 5 1047 1053 15111519
  13. [16]Basavanagowdappa H Prabhakar AK Prasannaraj P Gurudev KC Suma V Study of prevalence of diabetes mellitus and impaired fasting glucose in a rural population International Journal of Diabetes in Developing Countries 2005 25 4 98 101
  14. [17]Fourlanos S Dotta F Greenbaum CJ Latent autoimmune diabetes in adults (LADA) should be less latent Diabetologia 2005 48 11 2206 2212 16193284
  15. [18]Turner R Stratton I Horton V UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes The Lancet 1997 350 9087 1288 1293 9357409
  16. [19]Tuomi T Carlsson Å Li H Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies Diabetes 1999 48 1 150 157 9892237
  17. [20]Castleden HA Shields B Bingley PJ GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes Diabetic Medicine 2006 23 8 834 838 16911619
  18. [22]Mlinar B Marc J Janež A Pfeifer M Molecular mechanisms of insulin resistance and associated diseases Clinica Chimica Acta 2007 375 1-2 20 35 16956601
  19. [23]Biesenbach G Auinger M Clodi M Prevalence of LADA and frequency of GAD antibodies in diabetic patients with end-stage renal disease and dialysis treatment in Austria Nephrology Dialysis Transplantation 2005 20 3 559 565 15671073
  20. [25]American Diabetic Association Standards of medical care in diabetes-2007 Diabetes Care 2007 30 1 S4 p. S41 17192377
  21. [26]Groop L Bottazzo GF Doniach D Islet cell antibodies identify latent type I diabetes in patients aged 35–75 years at diagnosis Diabetes 1986 35 2 237 241 3510930
  22. [27]Kasuga A Maruyama T Ozawa Y Antibody to the Mr 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese Journal of Autoimmunity 1996 9 1 105 111 8845047
  23. [28]Gottsater A Landin-Olsson M Lernmark A Fernlund P Sundkvist G Islet cell antibodies are associated with β-cell failure also in obese adult onset diabetic patients Acta Diabetologica 1994 31 4 226 231 7888694
  24. [29]DeFronzo RA Pathogenesis of type 2 (non-insulin-dependent) diabetes mellits: a balanced overview Diabetologia 1992 35 4 389 397 1516769
  25. [30]Porte D Jr. Banting lecture 1990. Beta-cells in type II diabetes mellitus Diabetes 1991 40 166 180 1991568
  26. [31]Lampeter EF Homberg M Quabeck K Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation The Lancet 1993 341 8855 1243 1244 8098394

Cited by

Sorted by citations

Authors
Brahmkshatriya, P. P., Mehta, A. A., Saboo, B. D., & Goyal, R. K.
Affiliations
  • Department of Pharmacology, L. J. Institute of Pharmacy, Sarkhej Gandhinagar Highway, Gujarat, Ahmedabad 380015, India
  • Department of Pharmacology, L. M. College of Pharmacy, Navrangpura, Gujarat, Ahmedabad 380009, India
  • Department of Endocrinology, Dia-Care Clinic, 2 Gandhi Park, Nehrunagar, Gujarat, Ahmedabad 380015, India
  • Department of Pharmacology SPP School of Pharmacy & Technology Management, Mumbai 400056, India
Corresponding author
Brahmkshatriya, Priyanka P.
ORCID
Venue
ISRN Pharmacology
Publisher
Wiley
Published
2012-04-08
Volume
2012
Pages
1-8
ISSN
  • 2090-5165 (ISSN-L)
  • 2090-5173
DOI
10.5402/2012/580202
PMC
PMC3339117
OpenAlex
W1974550710
Cited by
54
References
1
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 1 · 2019: 4 · 2018: 8 · 2017: 1 · 2016: 3 · 2014: 5 · 2013: 4 · 2012: 1
FWCI
1.93
Type
journal article
Language
en
Open access
Licence
Locations
  • ISRN Pharmacology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
All India Council for Technical Education
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
latent autoimmune diabetes in adults, glutamic acid decarboxylase antibodies, C-peptide, type 1 diabetes, type 2 diabetes, age of onset, diabetes duration, HbA1c, cholesterol, oral antidiabetic drugs, underdiagnosis, prevalence, diagnostic biomarkers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review