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Cited by 42Hemostasis and retained surgical itemsBlood transfusion and managementTrauma, Hemostasis, Coagulopathy, Resuscitation

Hemostatic Agents in Hepatobiliary and Pancreas Surgery: A Review of the Literature and Critical Evaluation of a Novel Carrier-Bound Fibrin Sealant (TachoSil)

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Simo, K. A., Hanna, E. M., Imagawa, D. K., Iannitti, D. A.·2012·ISRN Surgery
DOI 10.5402/2012/729086PMC PMC3458284
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Abstract

Background. Despite progress in surgical techniques applied during hepatobiliary and pancreas (HPB) surgery, bleeding and bile leak remain significant contributors to postoperative mortality and morbidity. Topical hemostatics have been developed and utilized across surgical specialties, but data regarding effectiveness remains inconsistent and sparse in HPB surgery. Methods. A comprehensive search for studies and reviews on hemostatics in HPB surgery was performed via an October 2011 query of Medline, EMBASE, and Cochrane Library. In-depth evaluation of a novel carrier-bound fibrin sealant (TachoSil) was also performed. Results. The literature review illustrates multiple attempts have been made at developing different topical hemostatics and sealants to aid in surgical procedures. In HPB surgery, efforts have been directed at decreasing bleeding, biliary leakage, and pancreatic fistula. Conflicting scientific evidence exists regarding the effectiveness of these agents. Critical evaluation of the literature demonstrates TachoSil is a valuable tool in achieving hemostasis, and possibly biliostasis and pancreatic fistula prevention. Conclusion. While progress has been made in topical hemostatics for HPB surgery, an ideal agent has not yet been identified. TachoSil is promising, but larger randomized, controlled clinical trials are required to more fully evaluate its efficacy in reducing bleeding, biliary leakage, and pancreatic fistulas in HPB surgery.

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  • In another clinical setting, TachoSil® significantly reduced postoperative adhesion formation, with one referenced trial showing that only 2 out of 22 patients (9%) treated with TachoSil had postoperative adhesions, compared to 13 out of 23 patients (57%) in the control group (p < 0.01).

    “In another clinical setting, TachoSil® significantly reduced postoperative adhesion formation, with one referenced trial showing that only 2 out of 22 patients (9%) treated with TachoSil had postoperative adhesions, compared to 13 out of 23 patients (57%) in the control group (p < 0.01) [75].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [75]

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  1. [1]Jarnagin WR Gonen M Fong Y Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade Annals of Surgery 2002 236 4 397 407 2-s2.0-0036786635 12368667 PMC1422593
  2. [2]Briceño J Naranjo A Ciria R A prospective study of the efficacy of clinical application of a new carrier-bound fibrin sealant after liver resection Archives of Surgery 2010 145 5 482 488 2-s2.0-77952331665 20479348
  3. [3]Makuuchi M Sano K The surgical approach to HCC: our progress and results in Japan Liver Transplantation 2004 10 2, supplement 1 S46 S52 2-s2.0-1242352399 14762839
  4. [4]Figueras J Llado L Miro M Application of fibrin glue sealant after hepatectomy does not seem justified: results of a randomized study in 300 patients Annals of Surgery 2007 245 4 536 542 2-s2.0-34147160137 17414601 PMC1877032
  5. [5]Kraus TW Mehrabi A Schemmer P Kashfi A Berberat P Büchler MW Scientific evidence for application of topical hemostats, tissue glues, and sealants in hepatobiliary surgery Journal of the American College of Surgeons 2005 200 3 418 427 2-s2.0-14544306926 15737854
  6. [6]Boonstra EA Molenaar IQ Porte RJ de Boer MT Topical haemostatic agents in liver surgery: do we need them? HPB 2009 11 4 306 310 2-s2.0-70349177778 19718357 PMC2727083
  7. [7]Spotnitz WD Burks S Hemostats, sealants, and adhesives: components of the surgical toolbox Transfusion 2008 48 7 1502 1516 2-s2.0-51249112320 18422855
  8. [8]Spotnitz WD Burks S Hemostats, sealants, and adhesives II: update as well as how and when to use the components of the surgical toolbox Clinical and Applied Thrombosis/Hemostasis 2010 16 5 497 514 2-s2.0-77955878441 20699255
  9. [9]Spotnitz WD Fibrin sealant: past, present, and future: a brief review World Journal of Surgery 2010 34 4 632 634 2-s2.0-77952419959 19820991
  10. [10]Berrevoet F de Hemptinne B Use of topical hemostatic agents during liver resection Digestive Surgery 2007 24 4 288 293 2-s2.0-34547436866 17657154
  11. [11]Hayashibe A Sakamoto K Shinbo M Makimoto S Nakamoto T New method for prevention of bile leakage after hepatic resection Journal of Surgical Oncology 2006 94 1 57 60 2-s2.0-33745675345 16788945
  12. [12]Adams GL Manson RJ Hasselblad V Shaw LK Lawson JH Acute in-vivo evaluation of bleeding with Gelfoam saline and Gelfoam plus human thrombin using a liver square lesion model in swine Journal of Thrombosis and Thrombolysis 2009 28 1 1 5 2-s2.0-67449083078 18629446
  13. [13]Leixnering M Reichetseder J Schultz A Gelatin thrombin granules for hemostasis in a severe traumatic liver and spleen rupture model in swine The Journal of Trauma 2008 64 2 456 461 2-s2.0-43149124002 18301215
  14. [14]Chapman WC Clavien PA Fung J Khanna A Bonham A Kram HB Effective control of hepatic bleeding with a novel collagen-based composite combined with autologous plasma: results of a randomized controlled trial Archives of Surgery 2000 135 10 1200 1205 2-s2.0-0033801924 11030881
  15. [15]Fingerhut A Veyrie N Ata T Alexakis N Leandros E Use of sealants in pancreatic surgery: critical appraisal of the literature Digestive Surgery 2009 26 1 7 14 2-s2.0-58149477335 19145082
  16. [16]Schwartz M Madariaga J Hirose R Comparison of a new fibrin sealant with standard topical hemostatic agents Archives of Surgery 2004 139 11 1148 1154 2-s2.0-7744224346 15545559
  17. [17]Joseph T Adeosun A Paes T Bahal V Randomised controlled trial to evaluate the efficacy of TachoComb H patches in controlling PTFE suture-hole bleeding European Journal of Vascular and Endovascular Surgery 2004 27 5 549 552 2-s2.0-1942435525 15079782
  18. [18]Rickenbacher A Breitenstein S Lesurtel M Frilling A Efficacy of TachoSil a fibrin-based haemostat in different fields of surgery—a systematic review Expert Opinion on Biological Therapy 2009 9 7 897 907 2-s2.0-67650363876 19527109
  19. [20]Haas S The use of a surgical patch coated with human coagulation factors in surgical routine: a multicenter postauthorization surveillance Clinical and Applied Thrombosis/Hemostasis 2006 12 4 445 450 17000889
  20. [21]Toro A Mannino M Reale G Di Carlo I TachoSil use in abdominal surgery: a review Jorunal of Blood Medicine 2011 2 31 36 22287861 PMC3262340
  21. [22]Dregelid EB Pedersen G Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: a feasibility study in pigs Journal of Emergencies, Trauma and Shock 2011 4 1 77 81 2-s2.0-79952369882 PMC3097586 21633573
  22. [23]Apestegui C Breitenstein S Dutkowski P Clavien PA Control of severe portal bleeding by carrier-bound fibrin sealant Surgery Today 2009 39 4 363 365 2-s2.0-63149186233 19319650
  23. [24]Abu Hilal M Hallam MJ Zeidan BA Pearce NW Management of a ruptured pseudoaneurysm of common hepatic artery following pancreaticoduodenectomy The Scientific World Journal 2007 7 1659 1662 2-s2.0-35848932761 PMC5901184 17982600
  24. [25]Shimamoto T Marui A Nishina T Saji Y Komeda M The TachoSil-pledget stitch: towards eradication of suture hole bleeding Annals of Thoracic Surgery 2008 86 6 2002 2004 2-s2.0-56049091517 19022038
  25. [26]Schelling G Block T Gokel M Blanke E Hammer C Brendel W Application of a fibrinogen-thrombin-collagen-based hemostyptic agent in experimental injuries of liver and spleen The Journal of Trauma 1988 28 4 472 475 2-s2.0-0023945922 2451032
  26. [27]Grottke O Braunschweig T Daheim N Effect of TachoSil in a coagulopathic pig model with blunt liver injuries Journal of Surgical Research 2010 171 1 234 239 2-s2.0-77951820546 20452609
  27. [28]Takács I Wegmann J Horváth S Efficacy of different hemostatic devices for severe liver bleeding: a randomized controlled animal study Surgical Innovation 2010 17 4 346 352 2-s2.0-78650747482 20870671
  28. [29]Pusateri AE Modrow HE Harris RA Advanced hemostatic dressing development program: animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in swine The Journal of Trauma 2003 55 3 518 526 2-s2.0-0141850120 14501897
  29. [30]Erdogan D de Graaf W van Gulik TM Adhesive strength of fibrinogen-coated collagen patch or liquid fibrin sealant in an experimental liver resection model in pigs European Surgical Research 2008 41 3 298 302 2-s2.0-51549103929 18797168
  30. [31]Eder F Meyer F Nestler G Halloul Z Lippert H Sealing of the hepatic resection area using fibrin glue reduces significant amount of postoperative drain fluid World Journal of Gastroenterology 2005 11 38 5984 5987 2-s2.0-28644432300 16273610 PMC4436721
  31. [32]Davidson BR Burnett S Javed MS Seifalian A Moore D Doctor N Experimental study of a novel fibrin sealant for achieving haemostasis following partial hepatectomy British Journal of Surgery 2000 87 6 790 795 2-s2.0-0034082046 10848861
  32. [33]Saif R Jacob M Robinson S Amer A Kei-Hui D Sen G Use of fibrin-based sealants and gelatin-matrix hemostats in laparoscopic liver surgery Surgical Laparoscopy Endoscopy & Percutaneous Techniques 2011 21 3 131 141 21654294
  33. [34]Capussotti L Ferrero A Viganò L Sgotto E Muratore A Polastri R Bile leakage and liver resection: where is the risk? Archives of Surgery 2006 141 7 690 694 2-s2.0-33746049227 16847242
  34. [35]Sarpel U Roayaie S Schwartz ME Labow DM The role of fibrin sealants in hepatic surgery Surgical Technology International 2007 16 31 36 2-s2.0-38649143502 17429765
  35. [36]Berrevoet F de Hemptinne B Clinical application of topical sealants in liver surgery: does it work? Acta Chirurgica Belgica 2007 107 5 504 507 2-s2.0-36349006368 18074908
  36. [37]Moench C Bechstein WO Hermanutz V Hoexter G Knaebel HP Comparison of the collagen haemostat Sangustop versus a carrier-bound fibrin sealant during liver resection; ESSCALIVER-Study Trials 2010 11, article 109 2-s2.0-78349267232 PMC2994851 21087530
  37. [38]Frilling A Stavrou GA Mischinger HJ Effectiveness of a new carrier-bound fibrin sealant versus argon beamer as haemostatic agent during liver resection: a randomised prospective trial Langenbeck’s Archives of Surgery 2005 390 2 114 120 2-s2.0-20144388773 15723234
  38. [39]Fischer L Seiler CM Broelsch CE Hemostatic efficacy of TachoSil in liver resection compared with argon beam coagulator treatment: an open, randomized, prospective, multicenter, parallel-group trial Surgery 2011 149 1 48 55 2-s2.0-78650176174 20385397
  39. [40]Mirza D Millar AJW Sharif K Vilca-Melendez H Rela M Heaton N The use of TachoSil in children undergoing liver resection with or without segmental liver transplantation European Journal of Pediatric Surgery 2011 21 2 111 115 2-s2.0-79953906904 21494994
  40. [41]Lacanna F Brunati A Reding R A new biological mesh for cut surface hemostasis in liver transplantation using technical variants Pediatric Transplantation 2008 12 5 520 521 2-s2.0-55949134001 18672482
  41. [42]Toti L Attia M Manzia TM Reduction in bile leaks following adult split liver transplant using a fibrin-collagen sponge: a pilot study Digestive and Liver Disease 2010 42 3 205 209 2-s2.0-76049121183 19913466
  42. [43]Saxena AK Van Tuil C Advantages of fibrin glue spray in laparoscopic liver biopsies Surgical Laparoscopy, Endoscopy and Percutaneous Techniques 2007 17 6 545 547 2-s2.0-37549066899 18097320
  43. [44]Nakajima K Yasumasa K Endo S A simple application technique of fibrin-coated collagen fleece (TachoComb) in laparoscopic surgery Surgery Today 2007 37 2 176 179 2-s2.0-33846501551 17243043
  44. [45]Scheyer M Zimmermann G Tachocomb used in endoscopic surgery Surgical Endoscopy 1996 10 5 501 503 2-s2.0-0030139219 8658326
  45. [46]Carbon RT Baar S Waldschmidt J Huemmer HP Simon SI Innovative minimally invasive pediatric surgery is of therapeutic value for splenic injury Journal of Pediatric Surgery 2002 37 8 1146 1150 2-s2.0-0036325711 12149690
  46. [47]Erdogru T Sanli A Celik O Baykara M Laparoscopic transvesical repair of recurrent vesicovaginal fistula using with fleece-bound sealing system Archives of Gynecology and Obstetrics 2008 277 5 461 464 2-s2.0-41549113880 18038234
  47. [48]Falsaperla M Autorino R Puglisi M Haemostatic agents during laparoscopic nephron-sparing surgery: what about TachoSil? BJU International 2009 104 2 270 271 2-s2.0-67650647139 19594516
  48. [49]Rane A Rimington PD Heyns CF van der Merwe A Smit S Anderson C Evaluation of a hemostatic sponge (TachoSil) for sealing of the renal collecting system in a porcine laparoscopic partial nephrectomy survival model Journal of Endourology 2010 24 4 599 603 2-s2.0-77951943928 20218894
  49. [50]Low JK Ayiomamitis GD Hamoudi A Ammori BJ Spontaneous rupture of the splenic capsule with massive bleeding subsequent to the pringle maneuver during laparoscopic liver resection Surgical Laparoscopy, Endoscopy and Percutaneous Techniques 2011 21 2 e84 e86 2-s2.0-79955053345 21471788
  50. [51]Mita K Ito H Fukumoto M Pancreaticojejunostomy using a fibrin adhesive sealant (TachoComb) for the prevention of pancreatic fistula after pancreaticoduodenectomy Hepato-Gastroenterology 2011 58 105 187 191 2-s2.0-79955046649 21510312
  51. [52]Mita K Ito H Fukumoto M A fibrin adhesive sealing method for the prevention of pancreatic fistula following distal pancreatectomy Hepato-Gastroenterology 2011 58 106 604 608 2-s2.0-79958128071 21661439
  52. [53]Chirletti P Caronna R Fanello G Pancreaticojejunostomy with applicationof fibrinogen/thrombin-coated collagen patch (TachoSil) in roux-en-Y reconstruction after pancreaticoduodenectomy Journal of Gastrointestinal Surgery 2009 13 7 1396 1398 2-s2.0-67349122617 19381733
  53. [54]Lorenz U Maier M Steger U Töpfer C Thiede A Timm S Analysis of closure of the pancreatic remnant after distal pancreatic resection HPB 2007 9 4 302 307 2-s2.0-34547934831 18345309 PMC2215401
  54. [55]Pavlik Marangos I Røsok BI Kazaryan AM Rosseland AR Edwin B Effect of TachoSil patch in prevention of postoperative pancreatic fistula Journal of Gastrointestinal Surgery 2011 15 9 1625 1629 2-s2.0-79958139902 21671113 PMC3159765
  55. [56]Røsok BI Marangos IP Kazaiyan AM Single-centre experience of laparoscopic pancreatic surgery British Journal of Surgery 2010 97 6 902 909 2-s2.0-77952749574 20474000
  56. [57]Seeliger H Christians S Angele MK Risk factors for surgical complications in distal pancreatectomy American Journal of Surgery 2010 200 3 311 317 2-s2.0-77956184552 20381788
  57. [58]Erdogan D Van Gulik TM Evolution of fibrinogen-coated collagen patch for use as a topical hemostatic agent Journal of Biomedical Materials Research B 2008 85 1 272 278 2-s2.0-41449113343 17806107
  58. [59]Lorenz D Scheele J The use of collagen fleece (Tachocomb) in pancreatic surgery Zeitschrift für Experimentelle Chirurgie Transplantation und Künstliche Organe 1990 23 2 93 94 2-s2.0-0025579925 2278162

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Authors
Simo, K. A., Hanna, E. M., Imagawa, D. K., & Iannitti, D. A.
Affiliations
  • Carolinas Medical Center (US)
  • University of California, Irvine (US)
Corresponding author
Iannitti, D. A.
ORCID
Venue
ISRN Surgery
Publisher
Hindawi Limited
Published
2012-09-13
Volume
2012
Pages
1-12
ISSN
  • 2090-5785 (ISSN-L)
  • 2090-5793
DOI
10.5402/2012/729086
PMC
PMC3458284
OpenAlex
W2068177591
Cited by
42
References
0
Citations by year
2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 1
FWCI
1.83
Type
journal article
Language
en
Open access
Licence
Locations
  • ISRN Surgery (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords
topical hemostatic agents, TachoSil, hepatobiliary surgery, pancreatic surgery, postoperative bleeding, bile leakage, pancreatic fistula, surgical hemostasis

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