The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Allergic and intolerance reactions to wine
Open accessAbstract
) responsible for the noble rot in wines, yeasts and proteins from insects that contaminated the mash. Type 1 allergic reactions (positive prick tests) have been described for inorganic components like ethanol, acetaldehyde, acetic acid and sulfites, but no specific IgE could be detected in the serum. Ethanol, acetaldehyde and acetic acid, flavonoids (anthocyanins and chatechines), sulfites, histamine and other biogenic amines are the main causative agents of intolerance reactions (pseudoallergic reactions) to wine. After a short historic review of viticulture and the importance of wine in classical antiquity, we go into the chemical processes of alcoholic fermentation and the genetically inherited "flush syndrome" caused by an acetaldehyde dehydrogenase 2 polymorphism, subsequently we focus on the different etiologic factors of allergies and intolerance reactions to wine. The most frequent intolerance reactions to sulfites occur particularly after the ingestion of white wine and in asthma patients. Intolerance reactions to histamine and other biogenic amines occur mainly after ingestion of red wine and in persons with diamine oxidase (DAO) deficiency.
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![Figure 1. Classification of hypersensitivity reactions to wine (following the EAACI and WAO nomenclature [6, 7]).](/paper-figures/2b1cd8b000a7479c8c6f0f9c170f2554/allergic-and-intolerance-reactions-to-wine-figure-1.jpg)
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“Other biogenic amines present in food, such as monoamine tyramine, diamines putrescine and cadaverine, as well as polyamines spermine and spermidine, can affect DAO activity and consequently cause HIT symptoms.”
From Evaluation of Serum Diamine Oxidase as a Diagnostic Test for Histamine Intolerance (2023) · cites this paper as [4]
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Johansson, S. G. O., Bieber, T., Dahl, R., Friedmann, P. S., Lanier, B. Q., Lockey, R. F., Motala, C., Ortega Martell, J. A., Platts-Mills, T. A. E., Ring, J., et al. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.591 · Cited by 2,391
Johansson, S. G. O., Hourihane, J. O., Bousquet, J., Bruijnzeel-Koomen, C., Dreborg, S., Haahtela, T., Kowalski, M. L., Mygind, N., Ring, J., van Cauwenberge, P., et al. (2001) · Allergy · doi:10.1034/j.1398-9995.2001.t01-1-00001.x · Cited by 1,723
ALDEHYDE DEHYDROGENASE DEFICIENCY AS CAUSE OF FACIAL FLUSHING REACTION TO ALCOHOL IN JAPANESE
Harada, S., Agarwal, D. P., & Goedde, H. W. (1981) · The Lancet · doi:10.1016/s0140-6736(81)91172-7 · Cited by 539
Pastorello, E. A., Farioli, L., Pravettoni, V., et al. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.35 · Cited by 191
Alcohol and migraine: trigger factor, consumption, mechanisms. A review
Panconesi, A. (2008) · The Journal of Headache and Pain · doi:10.1007/s10194-008-0006-1 · Cited by 165
Anaphylaxis syndromes related to a new mammalian cross-reactive carbohydrate determinant
Commins, S. P., & Platts‐Mills, T. A. E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.08.026 · Cited by 156
Role of sulfite additives in wine induced asthma: single dose and cumulative dose studies
Vally, H. (2001) · Thorax · doi:10.1136/thorax.56.10.763 · Cited by 155
RED WINE AS A CAUSE OF MIGRAINE
Littlewood, J. T., Glover, V. A. S., Davies, P. T. G., Gibb, C., Sandler, M., & Rose, F. C. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91353-0 · Cited by 143
Alcoholic drinks: Important triggers for asthma
Vally, H., de Klerk, N., & Thompson, P. J. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.104548 · Cited by 122
Schäd, S. G., Trcka, J., Vieths, S., Scheurer, S., Conti, A., Bröcker, E., & Trautmann, A. (2005) · International Archives of Allergy and Immunology · doi:10.1159/000083324 · Cited by 93
Research works printed but not linked: 3
- [41]Dalton-Bunnow MF Review of sulfite sensitivity. Am J Hosp Pharm. 1985; 42: 2220– 2226. 3904432
- [42]Jarisch R Histamin-Intoleranz – Histamin und Seekrankheit. 2. neubearbeitete und erweiterte Auflage. Stuttgart – New York: Georg Thieme; 2004.
- [44]Komericki P Klein G Hawranek T Histamin-Intoleranz und oral verabreichte Diaminoxidase: Ergebnisse einer Multicenter-Studie. J Dtsch Dermatol Ges. 2009; 7: 203– 204.
Cited by
Evaluation of Serum Diamine Oxidase as a Diagnostic Test for Histamine Intolerance
Arih, K., Đorđević, N., Košnik, M., & Rijavec, M. (2023) · Nutrients · doi:10.3390/nu15194246 · Cited by 20
Metadata
- Authors
- Wüthrich, B.
- Affiliations
- Spital Zollikerberg (CH)
- Corresponding author
- Wüthrich, B.
- Venue
- Allergologie select
- Publisher
- Dustri-Verlgag Dr. Karl Feistle
- Published
- 2018-01-01
- Volume
- 2
- Issue
- 01
- Pages
- 80-88
- ISSN
- 2512-8957 (ISSN-L)
- PMC
- PMC6883207
- OpenAlex
- W2992340228
- Cited by
- 35
- References
- 39
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 3
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Allergologie select (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Fermentation and Sensory Analysis
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Keywords
- histamine intolerance, biogenic amines, acetaldehyde, ethanol, acetic acid, anthocyanins, anaphylactoid reactions, skin prick test, specific IgE, alcoholic fermentation, asthma, white wine, red wine
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- Wüthrich, B. (2018). Allergic and intolerance reactions to wine. Allergologie select. https://doi.org/10.5414/alx01420e
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
