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Inhibition of cross-reactive carbohydrate determinants (CCDs) enhances the selectivity of in vitro allergy diagnosis

Aberer, W., Holzweber, F., Hemmer, W., Koch, L., Bokanovic, D., Fellner, W., Altmann, F.·2017·Allergologie select
DOI 10.5414/alx01638ePMC PMC6040007
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Figure 1. Production of the CCD blocker from human serum albumin (HSA) and the MUXF glycopeptide.
Figure 1. Production of the CCD blocker from human serum albumin (HSA) and the MUXF glycopeptide.CC BY · PubMed Central
Figure 2. Effect of the synthetic CCD blocker. Results for patients with anti-CCD IgE antibodies and one without such cross-reactive IgEs, as obtained on the Mediwiss test strip without (n) and with (i) an inhibitor. The left strips contained inhalant allergens (P, positive control; CCD, mixture of bromelain, horseradish peroxidase and ascorbate oxidase). Vegetable and animal foods as well as bromelain, horseradish peroxidase and ascorbate oxidase were applied on the right strip as CCD indicators. The symptoms of the CCD-positive patient were confined to perennial nasal congestion.
Figure 2. Effect of the synthetic CCD blocker. Results for patients with anti-CCD IgE antibodies and one without such cross-reactive IgEs, as obtained on the Mediwiss test strip without (n) and with (i) an inhibitor. The left strips contained inhalant allergens (P, positive control; CCD, mixture of bromelain, horseradish peroxidase and ascorbate oxidase). Vegetable and animal foods as well as bromelain, horseradish peroxidase and ascorbate oxidase were applied on the right strip as CCD indicators. The symptoms of the CCD-positive patient were confined to perennial nasal congestion.CC BY · PubMed Central

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Citations

Cites

  • The Role of Protein Glycosylation in Allergy

    Altmann, F. (2007) · International Archives of Allergy and Immunology · doi:10.1159/000096114 · Cited by 393 · cited 1×

    “Specific IgE antibodies to cross-reactive carbohydrate determinants (CCDs) in the serum of persons with pollen allergy are responsible for cross-reactivity with several inhalant and food allergens as well as insect venom and latex [1, 2, 3, 4, 5, 6, 7, 8].”
    BackgroundSelf-citation

Research works printed but not linked: 18

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Metadata

Authors
Aberer, W., Holzweber, F., Hemmer, W., Koch, L., Bokanovic, D., Fellner, W., & Altmann, F.
Venue
Allergologie select
Publisher
Dustri-Verlgag Dr. Karl Feistle
Published
2017-07-01
Volume
1
Issue
2
Pages
141-149
ISSN
2512-8957
DOI
10.5414/alx01638e
PMC
PMC6040007
Cited by
14
References
1
Language
en

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