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Cited by 9Dental Health and Care UtilizationOral microbiology and periodontitis researchSalivary Gland Disorders and Functions

Antiasthmatic Inhaled Medications as Favoring Factors for Increased Concentration of Streptococcus Mutans

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Brigic, Amela, Kobaslija, Sedin, Zukanovic, Amila·2015·Materia Socio Medica
DOI 10.5455/msm.2015.27.237-240PMC PMC4610621
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Abstract

INTRODUCTION: The negative impact of inhaled antiasthmatic drugs (IAD) on oral health is reflected primarily in the increased incidence of caries in asthmatic children compared to healthy children. It is believed that one of the causes of the increased incidence of caries in asthmatic children is from bronchodilator effect in reduced secretion of saliva. Decreased salivation favors bacterial colonization and studies have shown that the concentration of Streptococcus mutans, a bacterium that has the primary role in the development of caries, is higher in asthmatic than in healthy children. MATERIAL AND METHODS: The study sample consisted of 200 patients, age from 7-14 years, divided into two groups: control group (n1 = 100) consisted of healthy children and the experimental group consisted of children suffering from asthma (n2 = 100). In both groups of respondents are identified the DMFT values, the concentration of Streptococcus mutans, the amount of stimulated saliva and plaque index value. RESULTS: It was found that there are significant differences in the values of plaque index, salivary index and streptococcus mutans between the control and experimental groups (p> 0.05 for each of the examined variables). Those in the control group had significantly higher DMFT index than subjects in the experimental group (p = 0.004). CONCLUSION: IAD does not cause reduced saliva production and thus do not represent a factor favoring increased concentration of Streptococcus mutans.

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  • Anti-asthmatic medications or their effects decrease salivary pH and flow.

    “These effects lead to decreases in the salivary pH and flow”

    From Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health (2023) · cites this paper as [31]

    The Introduction suggests that bronchodilators may reduce saliva secretion, but the paper’s Abstract Conclusion says inhaled antiasthmatic drugs did not reduce saliva production in the children studied. The cited passages do not address salivary pH, so they cannot support that part of the claim. (LLM, conf=0.85)

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  • Anti-asthmatic medications or their effects increase the presence of Streptococcus mutans and Lactobacillus acidophilus.

    “and increases the presence of Streptococcus mutans and Lactobacillus acidophilus”

    From Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health (2023) · cites this paper as [31]

    The Abstract Conclusion states that inhaled antiasthmatic drugs do not favor an increased concentration of Streptococcus mutans, contrary to the attributed claim. The Introduction mentions higher S. mutans concentrations in asthmatic children, but the paper does not report an increase in Lactobacillus acidophilus. (LLM, conf=0.88)

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  • Increased presence of Streptococcus mutans and Lactobacillus acidophilus increases susceptibility to oral pathologies.

    “which increases an individual’s susceptibility to the development of oral pathologies [30,31,32].”

    From Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health (2023) · cites this paper as [31]

    The Introduction (page not available) reports a positive correlation between increased Streptococcus mutans and dental caries, and says Lactobacillus participates in caries progression. It does not identify Lactobacillus acidophilus or establish increased susceptibility to oral pathologies beyond caries. The Discussion also cautions that S. mutans colonization alone cannot establish caries risk in older children. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Non-asthmatic subjects presented with a significantly higher DMTF index than asthmatic subjects (p = 0.004).

    “In the study, Brigic et al. [31] reported the cariogenic potential of inhaled anti-asthmatic medications, observing that non-asthmatic subjects presented with a significantly higher DMTF index than asthmatic subjects (p = 0.004).”

    From Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health (2023) · cites this paper as [31]

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Research works printed but not linked: 21

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Authors
Brigic, A., Kobaslija, S., & Zukanovic, A.
Affiliations
University Clinical Center Tuzla (BA)
Corresponding author
Brigic, Amela
Venue
Materia Socio Medica
Publisher
ScopeMed
Published
2015
Volume
27
Issue
4
Pages
237
ISSN
1512-7680 (ISSN-L)
DOI
10.5455/msm.2015.27.237-240
PMC
PMC4610621
OpenAlex
W1085484407
Cited by
9
References
0
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 1 · 2018: 1
FWCI
0.45
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Materia Socio Medica (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
Keywords
Streptococcus mutans, asthma, dental caries, salivary secretion, plaque index, DMFT index, children, oral health, bronchodilators

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