Expression patterns of PRDM10 during mouse embryonic development
Open accessAbstract
It is well known that PR/SET family members participate in transcriptional regulation via chromatin remodeling. PRDM10 might play an essential role in gene expression, but no such evidence has been observed so far. To assess PRDM10 expression at various stages of mouse development, we performed immunohistochemistry using available PRDM10 antibody. Embryos were obtained from three distinct developmental stages. At E8.5, PRDM10 expression was concentrated in the mesodermal and neural crest populations. As embryogenesis proceeded further to E13.5, PRMD10 expression was mainly in mesoderm-derived tissues such as somites and neural crest-derived populations such as the facial skeleton. This expression pattern was consistently maintained to the fetal growth period E16.5 and adult mouse, suggesting that PRDM10 may function in tissue differentiation. Our study revealed that PRDM10 might be a transcriptional regulator for normal tissue differentiation during mouse embryonic development. [BMB reports 2010; 43(1): 29-33].
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PRDM10 may be related to dendrite growth and neural crest related changes that contributed to the formation of our distinct modern face.
“Although little is known about PRDM10, it may be related to dendrite growth147 and neural crest related changes that contributed to the formation of our distinct modern face148.”
From A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) · cites this paper as [148]
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References 22 · Cited by 27
- Authors
- Park, J.-A., & Kim, K.-C.
- Affiliations
- Kangwon National University (KR)
- ORCID
- Kim, Keun-Cheol
- Venue
- BMB Reports
- Published
- 2010-01-31
- Volume
- 43
- Issue
- 1
- Pages
- 29-33
- ISSN
- 1976-6696 (ISSN-L)
- OpenAlex
- W2036186362
- Cited by
- 27
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 1 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMB Reports (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Korea Basic Science Institute
- Ministry of Education, Science and Technology
- Division of Materials Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Renal and related cancers
- Keywords
- mouse embryo development, gene expression patterns, mesoderm, neural crest, somites, facial skeleton, histogenesis, transcriptional regulation, chromatin remodeling
- MeSH terms
- Animals, Cell Differentiation, Immunohistochemistry, Mesoderm, Mice, Inbred ICR, Neural Crest, Transcription Factors, Somites, Organogenesis, Chromatin Assembly and Disassembly, Embryonic Development, Mice
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