The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy
Open accessAbstract
Autophagy, an evolutionarily conserved cellular degradation pathway of the lysosome, is associated with many physiological and pathological processes. The hallmark of autophagy is the formation of the autophagosome that engulfs and degrades cytosolic components via its fusion with the lysosome, in either a selective or a non-selective manner. Autophagy is tightly regulated by proteins encoded by autophagy-related (atg) genes. Among these proteins, ATG8/ LC3 is essential for autophagosome biogenesis/maturation and it also functions as an adaptor protein for selective autophagy. In mammalian cells, several homologs of yeast Atg8 such as MAP1LC3, GABARAP, and GABARAPL 1/2 have been identified. However, the biological relevance of this gene diversity in higher eukaryotes, and their specific roles, are largely unknown. In this review, we describe the mammalian ATG8/LC3 family and discuss recent advancements in understanding their roles in the autophagic process. [BMB Reports 2016; 49(8): 424-430].
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1 retracted
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“Instead, a single-membrane structure is generated, which is involved in the efficient clearance of dead cells (8).”
BackgroundRetractedAutophagosome formation: core machinery and adaptations
Xie, Z., & Klionsky, D. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1102 · Cited by 2,164
The machinery of macroautophagy
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Autophagy: from phenomenology to molecular understanding in less than a decade
Klionsky, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2245 · Cited by 1,934
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
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The LIR motif – crucial for selective autophagy
Birgisdottir, Å. B., Lamark, T., & Johansen, T. (2013) · Journal of Cell Science · doi:10.1242/jcs.126128 · Cited by 885
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Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation
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Cited by
Mareninova, O. A., Jia, W., Gretler, S. R., Holthaus, C. L., Thomas, D. D. H., Pimienta, M., Dillon, D. L., Gukovskaya, A. S., Gukovsky, I., & Groblewski, G. E. (2020) · Autophagy · doi:10.1080/15548627.2020.1715047 · Cited by 118
Daniele, L. L., Caughey, J., Volland, S., Sharp, R. C., Dhingra, A., Williams, D. S., Philp, N. J., & Boesze-Battaglia, K. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00185.2019 · Cited by 16
Berkamp, S., Jungbluth, L., Katranidis, A., Mostafavi, S., Korculanin, O., Lu, P.-H., Ickert, L., Dierig, M. M., Sharma, L., Thukral, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66785-7 · Cited by 12
Metadata
- Authors
- Lee, Y.-K., & Lee, J.-A.
- Venue
- BMB Reports
- Published
- 2016-08-31
- Volume
- 49
- Issue
- 8
- Pages
- 424-430
- ISSN
- 1976-6696 (ISSN-L)
- OpenAlex
- W2484914234
- Cited by
- 375
- References
- 43
- FWCI
- 19.35
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lee, Y.-K., & Lee, J.-A. (2016). Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy. BMB Reports. https://doi.org/10.5483/bmbrep.2016.49.8.081
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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