Double-blind randomized controlled study of the efficacy, safety and tolerability of eszopiclone vs placebo for the treatment of patients with post-traumatic stress disorder and insomnia
Open accessAbstract
BACKGROUND: Sleep disturbance is a core feature of post-traumatic stress disorder (PTSD). Given the relationship between sleep disturbance and PTSD, there has been a relative paucity of studies examining the potential therapeutic impact of using pharmacotherapy to target sleep disturbance in patients with PTSD. Eszopiclone (ESZ) is a non-benzodiazepine y-aminobutyric acid-A receptor agonist indicated for the treatment of sleep and may affect sleep in patients with PTSD. AIM: placebo (PBO) for patients with PTSD and insomnia. METHODS: = 12). RESULTS: = 0.69. Adverse events of ESZ were consistent with the known profile of the medication including dysgeusia (30%, mild), sedation (20%, mild) and headache (20%, moderate to severe). CONCLUSION: Results do not support the hypothesis of a specific positive effect of ESZ compared to PBO for measures of PTSD and associated sleep disturbance.
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Robust CD4+ and CD8+ T cell memory is induced after COVID-19, and multiple COVID-19 vaccines elicit CD4+ and CD8+ T cell responses.
“Robust CD4+ and CD8+ T cell memory is induced after COVID-19,22,39, 40, 41 and multiple COVID-19 vaccines elicit CD4+ and CD8+ T cell responses.26,42, 43, 44, 45”
From Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals (2021) · cites this paper as [42]
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References 32 · Cited by 19
Research works printed but not linked: 1
- [25]First MB Spitzer RL Gibbon M Williams JBW Structured clinical interview for DSM-IV-TR Axis I Disorders, Research Version, Non-patient Edition (SCID-I/P) New York: New York State Psychiatric Institute, 1995
- Authors
- Dowd, S. M., Zalta, A. K., Burgess, H. J., Adkins, E. E., Valdespino-Hayden, Z., & Pollack, M. H.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Dowd, Sheila M
- Venue
- World Journal of Psychiatry
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2020-03-19
- Volume
- 10
- Issue
- 3
- Pages
- 21-28
- ISSN
- 2220-3206 (ISSN-L)
- PMC
- PMC7099286
- OpenAlex
- W3010020212
- Cited by
- 19
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 2
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Psychiatry (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Rush University
- National Institute of Mental Health (K23MH103394)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- eszopiclone, post-traumatic stress disorder, insomnia, sleep disorders, GABA-A receptor agonists, non-benzodiazepine hypnotics, pharmacotherapy, adverse events, sedation, dysgeusia
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