The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder (eng)
Open accessAbstract
oksidatif stres ve nörokognisyon SUMMARY Objective: The number of studies investigating oxidative stress levels in OCD subtypes is limited.This study aimed to compared total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index values between OCD subtypes and to determine relationship between oxidative stress and neurocognitive function.Method: T19 autogenous type OCD, 21 reactive type OCD and 42 healthy controls were taken to this study.All patients were rated using the Yale-Brown Obsessive Compulsive Scale, the Metacognition Questionnaire, the Beck Depression Inventory and Beck Anxiety Inventory, the Wisconsin Card Sorting Test, and the Stroop test.Serum TOS and TAS levels were determined.Results: TAS levels were significantly higher in patients with OCD (p=0.018)than in the healthy controls.TAS levels were also significantly higher in patients with RT type OCD than in the healthy controls (p=0.003).In RT OCD, TAS was correlated with the Wisconsin Card Sorting Test -trials to complete the first category (p=0.02) and the Metacognition Questionnaire -need to control thoughts (p=0.02)subscales.Discussion: The study findings indicated an overall oxidative imbalance shift toward the antioxidant side in patients with OCD and RT type OCD.This may be a way of coping with the disease.The correlation between TAS and the Wisconsin Card Sorting Test -trials to complete the first category subscale suggests that the change in serum TAS level may be a condition that for overcoming mental inflexibility.These results should be confirmed by prospective studies.
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“Furthermore, methodological factors such as sample size, depressive symptom burden, and variations in neuropsychological assessment strategies may have contributed to the variability of reported results [5,11,12,13].”
From Comparison of Cognitive Functions in Patients with Autogenous and Reactive Obsessive-Compulsive Disorder (2026) · cites this paper as [13]
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Cites
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Kaloğlu, H. A., Ünler, M., Koparal, B., Utku, Ç., & Yüksel, N. (2026) · Brain Sciences · doi:10.3390/brainsci16090922
Metadata
- Authors
- Özkorumak Karagüzel, E., Civil Arslan, F., Demir, S., Saglam Aykut, D., Demirtaş, Y., & Karahan, S. C.
- Affiliations
- Karadeniz Technical University (TR)
- Venue
- Journal of Clinical Psychiatry
- Publisher
- LookUs Bilisim A.S.
- Published
- 2022
- Volume
- 25
- Issue
- 1
- Pages
- 15-22
- ISSN
- 1302-0099 (ISSN-L)
- OpenAlex
- W4285204280
- Cited by
- 2
- References
- 37
- Citations by year
- 2026: 1 · 2023: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Clinical Psychiatry (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, oxidative stress, total antioxidant status, total oxidant status, neurocognitive function, executive function, metacognition, need to control thoughts, serum biomarkers
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