Distribution of nuclear receptors for steroid hormones in the human brain: a preliminary study
Open accessAbstract
BACKGROUND: Expression of the nuclear steroid hormone receptors (SHR) within certain parts of the human brain has been described by many authors. However, a comprehensive analysis of SHR expression in the human brain still has not been performed. AIM: To investigate the expression of SHR in different anatomical areas of the brain, especially within the neocortex. METHOD: Immunohistochemical expression of estrogen receptors (ER), progesterone receptors (PR) and androgen receptors (AR) in different regions of the human brain was examined. RESULTS: Nuclear expression of the AR was found in the mamillary body, praecentral gyrus and hippocampus of males. The same expression in analysed structures of female was not found. The expression of ER and PR was not observed. CONCLUSIONS: The analysis revealed unexpected localization of SHR within the brain cortex, which could be the first step to the explanation of SHR action in brain as an interrelationship to function and behaviour. These results indicate on the possibility of SHR detection in post-mortal brain.
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In adults, AR is expressed across the cerebral cortex, including associative cortex, in both sexes in rodents and humans.
“In adults AR is expressed across the cerebral cortex, including associative cortex, in both sexes in rodents (Clancy et al., 1992; Dart et al., 2013; DonCarlos et al., 2006; Feng et al., 2010; Kritzer, 2004; Simerly et al., 1990; Young and Chang, 1998), and humans (Bezdickova et al., 2007; Puy et al., 1995; Sarrieau et al., 1990).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Bezdickova et al., 2007
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References 11 · Cited by 26
Research works printed but not linked: 1
- Fernandez-Guasti A, Kruijver FP, Fodor M, Swaab DF. Sex diff er- ences in the distribution of the androgen receptors in the human hypothalamus. J Comp.Neurol. 2000; 425(3):422-35.
- Authors
- Bezdickova, M., Molikova, R., Bebarova, L., & Kolar, Z.
- Affiliations
- Palacký University Olomouc (CZ)
- Venue
- Biomedical Papers
- Publisher
- Palacky University Olomouc
- Published
- 2007-06-01
- Volume
- 151
- Issue
- 1
- Pages
- 69-71
- ISSN
- 1213-8118 (ISSN-L)
- 1804-7521
- OpenAlex
- W2096533125
- Cited by
- 26
- References
- 11
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 4 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Biomedical Papers (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- human brain, estrogen receptor, progesterone receptor, androgen receptor, neocortex, hippocampus, mammillary bodies, sex differences, postmortem brain
- MeSH terms
- Adult, Aged, Brain, Female, Humans, Immunohistochemistry, Male, Middle Aged, Receptors, Steroid, Receptors, Cytoplasmic and Nuclear
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