The DOI matches its Crossref record; 11 of the 13 references it cites were found in a registry or an index.
Adverse Drug Reactions in Patients put on Multi Drug Resistant Tuberculosis (MDR-TB) Treatment in Seven Districts of Central Gujarat
Open accessAbstract
Aim: To study the Adverse drug reactions (ADRs) experienced by MDR TB patients put on DOTS plus regimen.Material and Methods: The longitudinal cohort study was conducted by following a cohort of 142 MDR TB patients registered for DOTS plus therapy in 2010 under Revised National Tuberculosis Control Programme (RNTCP).Two follow ups were taken in a cohort of 142 MDR TB patients, first at completion of 6 months of treatment and second after completion of 24 months of treatment.Subjects were interviewed to study side effects of DOTS plus regimen.Results: After 6 months of treatment, 48.59% (69) patients developed ADRs and between 6 months and 24 months of treatment 54.93% (78) patients developed ADRs out of total 142 at both the milestones.GI disturbances were 54.9% at 1st follow up and 46.54% at second follow up.Other side effects like headache, arthralgias, decreased hearing and skin reactions were also reported in varying frequencies.Average duration of ADRs was 60-90 days at both the follow ups.62.68% of all ADRs were managed by symptomatic treatment and dose reduction was done in 4.47% of the patients in 2 nd follow up.Conclusion: ADRs were experienced by more than half of the patients in the study and they increased as the duration of treatment increased.GI disturbances, Headache and Arthalgia were most common ADRs among patients.Most of them were managed by symptomatic treatment.
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Cited by
Alene, K. A., Clements, A. C. A., McBryde, E. S., Jaramillo, E., Lönnroth, K., Shaweno, D., Gulliver, A., & Viney, K. (2018) · Journal of Infection · doi:10.1016/j.jinf.2018.07.007 · Cited by 119
As'hab, P. P., Keliat, B. A., & Wardani, I. Y. (2022) · Journal of Public Health Research · doi:10.4081/jphr.2021.2737 · Cited by 16
“Positive questions (1, 3, 5, 6, 8, 10, 13, 15, 19) answers “correct” score 0 and “wrong” score 1, negative questions (2, 4, 7, 9, 11, 12, 14, 16, 17, 18, 20) answer “correct” is worth 1 and “false” is worth 0.”
BackgroundFatima, S., Syeda, M. F., Adla, N., & Devi, R., V (2021) · Lung India · doi:10.4103/lungindia.lungindia_118_19 · Cited by 11
Parikh, K., Rupani, M. P., Dave, J. D., Parmar, V. B., & Singh, M. (2020) · The National Medical Journal of India · doi:10.4103/0970-258x.308234 · Cited by 10
Jakasania, A. H., Shringarpure, K. S., Kapadia, D., Sharma, R., Mehta, K. G., Prajapati, A. C., & Kathirvel, S. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05660-w · Cited by 9
Metadata
- Authors
- Vashrambhai Patel, S., Kapil Bhikhubhai, N., Bhimabhai patel, A., Samrat Shringarpure, K., Gautambhai Mehta, K., & Krishnakumar Shukla, L.
- Venue
- Journal of Young Pharmacists
- Publisher
- Manuscript Technomedia LLP
- Published
- 2015-12-21
- Volume
- 7
- Issue
- 4s
- Pages
- 425-431
- ISSN
- 0975-1483 (ISSN-L)
- 0975-1505
- OpenAlex
- W1957334515
- Semantic Scholar
- 72369d14c778cc50d556fc141cf082b7ca94318c
- Cited by
- 17
- References
- 13
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 2
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Young Pharmacists (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Keywords
- adverse drug reactions, multidrug-resistant tuberculosis, antitubercular agents, gastrointestinal diseases, headache, joint pain, hearing loss, skin reactions, dose reduction, symptomatic treatment, treatment duration, Gujarat
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