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Cited by 30Sexual function and dysfunction studiesDupuytren's Contracture and TreatmentsUrological Disorders and Treatments

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Comparison of Intralesional Hyaluronic Acid vs. Verapamil for the Treatment of Acute Phase Peyronie's Disease: A Prospective, Open-Label Non-Randomized Clinical Study

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Cocci, Andrea, Di Maida, Fabrizio, Cito, Gianmartin, Verrienti, Pierangelo, Laruccia, Nicola, Campi, Riccardo, Mari, Andrea, Di Mauro, Marina, Falcone, Marco, Cacciamani, Giovanni E., Garaffa, Giulio, Minervini, Andrea, Russo, Giorgio Ivan·2021·The World Journal of Men's Health
DOI 10.5534/wjmh.190108PMC PMC7994654
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Abstract

PURPOSE: To compare the efficacy and safety of intralesional hyaluronic acid (HA) as compared with verapamil injection in patients with Peyronie's disease (PD). MATERIALS AND METHODS: Between January 2015 and December 2018, men in PD acute phase were prospectively recruited. This open-label, prospective study included 2 different protocols. Group A: 8-week cycle of weekly intraplaque injections with HA; Group B: 8-week cycle of weekly intraplaque injections with verapamil. Penile curvature, plaque size, International Index of Erectile Function (IIEF)-15 score and visual analogue scale (VAS) were assessed at baseline and after 3 months. RESULTS: Two-hundred forty-four patients were enrolled. Of these, 125 received intralesional HA (Group A), 119 received intralesional verapamil (Group B). At enrollment, median age was 56.0 years (interquartile range [IQR]=47.0-63.0 years), median curvature 35.0° (IQR=25.0°-45.0°), median IIEF-15 score 19.0 (IQR=16.0-23.0), median VAS 4.0 (IQR=4.0-5.0). Median difference for IIEF-15 was 1.0 (95% confidence interval [CI]=1.12-1.94) in Group A and 0.0 (95% CI=-0.04-0.14) in Group B (p<0.05) and median difference for VAS score was -4.0 (95% CI=-4.11--3.65) in Group A and -1.0 (95% CI=-0.50-2.01) in Group B (p<0.05). Plaque size decreased by -1.50 mm (IQR=1.60-2.10 mm) in Group A and -1.20 in Group B (p=0.10), while penile curvature decreased by -9.50° (IQR=4.50°-13.00°) in group A and -4.50 (IQR=2.50-7.50) in Group B (p<0.01). CONCLUSIONS: Intralesional HA injections could represent a reliable treatment option for the conservative management of patients with acute phase of PD.

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  • While most patients have detectable plaque, some may be unaware of its presence.

    “However, it is essential to note that while most patients have detectable plaque, some may be unaware of its presence.104,121,122”

    From Research advances in Peyronie's disease: a comprehensive review on genomics, pathways, phenotypic manifestation, and therapeutic targets. (2024) · cites this paper as [121]

    The Introduction describes plaque formation in Peyronie’s disease, and Materials and Methods (Patient population; page not provided) required a palpable nodule or plaque for enrollment. That supports detectable plaque in this selected cohort, but does not establish how common detectable plaque is among patients generally. The paper does not address whether patients may be unaware of a plaque. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 23

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Metadata

Authors
Cocci, A., Di Maida, F., Cito, G., Verrienti, P., Laruccia, N., Campi, R., Mari, A., Di Mauro, M., Falcone, M., Cacciamani, G. E., Garaffa, G., Minervini, A., & Russo, G. I.
Affiliations
  • Azienda Ospedaliero-Universitaria Careggi (IT)
  • Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.
  • Department of Urology, Vittorio Emanuele II, University of Catania, Catania, Italy.
  • University of Turin (IT)
  • University of Verona (IT)
  • University College Hospital (GB)
  • University of Catania (IT)
Corresponding author
Cito, Gianmartin
ORCID
Venue
The World Journal of Men's Health
Publisher
XMLink
Published
2021
Volume
39
Issue
2
Pages
352
ISSN
  • 2287-4208 (ISSN-L)
  • 2287-4690
DOI
10.5534/wjmh.190108
PMC
PMC7994654
OpenAlex
W3003513284
Cited by
30
References
1
Citations by year
2026: 7 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 3
FWCI
2.92
Type
journal article
Language
en
Open access
Licence
Locations
  • The World Journal of Men s Health (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
Peyronie's disease, intralesional injection, hyaluronic acid, verapamil, penile curvature, plaque size, erectile function, treatment efficacy and safety, men's health, pain scores

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