The Relationship between Non-HDL Cholesterol and Other Lipid Parameters in Japanese Subjects
Open accessAbstract
Plasma non-HDL cholesterol (HDL-C) concentration that is simply estimated from plasma total cholesterol and HDL-C concentrations, without the influence of plasma triglyceride concentration, has been included as a therapeutic target for hypertriglyceridemic patients in the most recent National Cholesterol Education Program (NCEP) recommendations. In the present study, we estimated plasma non-HDL-C concentration in Japanese subjects to clarify the correlation of plasma non-HDL-C to other plasma lipid concentrations, and to evaluate the NCEP recommendation. Plasma non-HDL-C concentration has a positive correlation with low-density lipoprotein cholesterol (LDL-C) and triglyceride concentrations. From our analysis, 140 mg/dl of plasma LDL-C concentration, which is the level for the diagnosis of hyper-LDL cholesterolemia, corresponds to 169 mg/dl of non HDL-C concentration. The relationship between plasma non-HDL-C and LDL-C concentrations in Japanese subjects is quite similar to that described in the NCEP guideline. Thus, we suggest that non-HDL-C is a useful risk marker in Japan, as recommended by the NCEP.
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The non-HDL-C levels of Japanese individuals with dyslipidemia are 30 mg/dL higher than their LDL-C levels.
“the non-HDL-C levels of Japanese individuals with dyslipidemia was shown to be +30 mg/dL that of LDL-C74, 75).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [74]
Studies from Japan have shown similar findings regarding non-HDL-C.
“Studies from Japan have shown similar findings74, 75).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [74]
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References 11 · Cited by 25
- Authors
- Sugimoto, K., Isobe, K., Kawakami, Y., & Yamada, N.
- Affiliations
- University of Tsukuba (JP)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2005
- Volume
- 12
- Issue
- 2
- Pages
- 107-110
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2018615538
- Cited by
- 25
- References
- 11
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- non-HDL cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, hypertriglyceridemia, NCEP guidelines, cardiovascular risk markers, Japanese population
- MeSH terms
- Arteriosclerosis, Female, Humans, Japan, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Retrospective Studies, Risk Factors, Triglycerides, Biomarkers, Prevalence
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