Long-term potentiation and long-term depression of horizontal connections in rat motor cortex
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This paper reviews studies that investigated conditions resulting in long-lasting modifications of synaptic efficacy in horizontal connections within layers II/III of adult rat motor cortex using the in vitro slice preparation. Long-term potentiation (LTP) was induced by high frequency theta burst stimulation (TBS) when local synaptic inhibition was transiently suppressed by bicuculline methiodide application at the recording site immediately prior to TBS of the horizontal pathway. Without bicuculline, TBS failed to produce LTP. LTP could also be induced without Bic application by conjoint TBS of horizontal and vertical (ascending) inputs. By contrast, long-term depression (LTD) of horizontal transmission was induced by 10 min of 2 Hz stimulation. Depressed horizontal connections nevertheless retained the capability for synaptic strength increases. These studies indicate that synaptic modification across horizontally connected neurones is regulated both by the arrangement of their intrinsic circuits and by the availability of mechanisms for modification at individual synapses. Activity dependent forms of synaptic plasticity operating within horizontal connections may form a spatial substrate and mechanism for experience-dependent regulation of cortical representations.
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Animal studies have shown that bursts of 3-5 pulses at 50-100 Hz (theta rhythm) induce LTP/LTD when applied to the motor cortex or hippocampus.
“Animal studies have shown that bursts of 3-5 pulses at 50-100 Hz (theta rhythm) induce LTP/LTD when applied to the motor cortex or hippocampus (Hess & Donoghue, 1996; Larson, et al., 1986).”
From Theta burst stimulation to characterize changes in brain plasticity following mild traumatic brain injury: A proof-of-principle study (2015) · cites this paper as Hess & Donoghue, 1996
The Long-Term Potentiation section reports theta-burst-induced LTP in adult rat motor-cortex slices, but only with transient disinhibition or simultaneous stimulation of horizontal and vertical pathways; theta bursts alone failed. The Long-Term Depression section instead reports LTD after 2 Hz stimulation for 10 minutes. Our copy does not specify bursts of 3–5 pulses at 50–100 Hz or present hippocampal results for that protocol. (LLM, conf=0.88)
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References 23 · Cited by 127
Research works printed but not linked: 6
- Benardo L.S., Wong R.K.S. (1995) Inhibition in the cortical network. In: The cortical neuron. (Eds. M. Gutnick and I. Mody). Oxford University Press, Oxford, p. 141-155.
- Donoghue J.P., Hess G., Sanes J.N. (1996) Substrates and mechanisms for learning in motor cortex. In: Acquisition of motor behavior in vertebrates (Eds. J. Bloedel, T. Ebner and S.P. Wise). MIT Press, Boston (in press).
- Hess G., Aizenman C.D., Donoghue J.P. (1996) Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex. J. Neuro- physiol. (in press)
- Hess G., Donoghue J.P. (1996) Long-term depression of hori- zontal connections in rat motor cortex. Eur. J. Neurosci. (in press)
- Jacobs K.M. (1994) The functional architecture of neocortical circuits. Ph.D. Thesis. Brown University, Providence, R.I., USA.
- Wigstrom H., Gustafsson B. (1985) Facilitation of hippocam- (Eds. E.G. Jones and A. Peters). Vol. 5. Plenum Press, New pal long-lasting potentiation by GABA antagonists. Acta York, p. 243-269. Physiol. Scand. 125: 159-172. Paper presented at the 2nd International Congress of the
- Authors
- Hess, G., & Donoghue, J.
- Affiliations
- Jagiellonian University (PL)
- Brown University (US)
- Venue
- Acta Neurobiologiae Experimentalis
- Published
- 1996-03-31
- Volume
- 56
- Issue
- 1
- Pages
- 397-405
- ISSN
- 0065-1400 (ISSN-L)
- 1689-0035
- OpenAlex
- W208251941
- Cited by
- 127
- References
- 23
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 4 · 2012: 6
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Acta Neurobiologiae Experimentalis (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns022517-16)
- National Institute of Neurological Disorders and Stroke (NS 22517)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- long-term potentiation, long-term depression, motor cortex, horizontal connections, theta burst stimulation, bicuculline, synaptic plasticity, synaptic inhibition, layer 2/3
- MeSH terms
- Animals, Motor Cortex, Neural Pathways, Neuronal Plasticity, Long-Term Potentiation, Rats
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