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Cited by 286Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and ResearchPancreatic function and diabetes

Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and pre-diabetes screening: Developments in research and prospects for the future

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Tang, Qi, Li, Xueqin, Song, Peipei, Xu, Lingzhong·2015·Drug Discoveries & Therapeutics
DOI 10.5582/ddt.2015.01207
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Abstract

Diabetes mellitus (DM) appears to be increasing rapidly, threatening to reduce life expectancy for humans around the globe. The International Diabetes Federation (IDF) has estimated that there will be 642 million people living with the disease by 2040 and half as many again who will be not diagnosed. This means that pre-DM screening is a critical issue. Insulin resistance (IR) has emerged as a major pathophysiological factor in the development and progression of DM since it is evident in susceptible individuals at the early stages of DM, and particularly type 2 DM (T2DM). Therefore, assessment of IR via the homeostasis model assessment of IR (HOMA-IR) is a key index for the primary prevention of DM and is thus found in guidelines for screening of high-risk groups. However, the cut-off values of HOMA-IR differ for different races, ages, genders, diseases, complications, etc. due to the complexity of IR. This hampers the determination of specific cut-off values of HOMA-IR in different places and in different situations. China has not published an official index to gauge IR for primary prevention of T2DM in the diabetic and non-diabetic population except for children and adolescents ages 6-12 years. Hence, this article summarizes developments in research on IR, HOMA-IR, and pre-DM screening in order to provide a reference for optimal cut-off values of HOMA-IR for the diagnosis of DM in the Chinese population.

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  • The results are very similar to those reported in three European countries (Sweden 2.0, France 3.8 and Portugal 2.33).

    “The results are very similar to those reported in three European countries (Sweden 2.0, France 3.8 and Portugal 2.33) [4].”

    From Optimal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Cut-Offs: A Cross-Sectional Study in the Czech Population (2019) · cites this paper as [4]

    Section 3.3 says published HOMA-IR cut-off values vary widely, and the References list studies from Sweden, France, and Portugal. The passages available from our copy do not give the claimed values of 2.0, 3.8, and 2.33, so the numerical comparison is not supported. (LLM, conf=0.76)

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References 54 · Cited by 286

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Authors
Tang, Q., Li, X., Song, P., & Xu, L.
Affiliations
  • Shandong University (CN)
  • The University of Tokyo (JP)
ORCID
Venue
Drug Discoveries & Therapeutics
Publisher
International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)
Published
2015
Volume
9
Issue
6
Pages
380-385
ISSN
  • 1881-7831 (ISSN-L)
  • 1881-784X
DOI
10.5582/ddt.2015.01207
OpenAlex
W2265429569
Cited by
286
References
54
Citations by year
2026: 15 · 2025: 25 · 2024: 22 · 2023: 44 · 2022: 47 · 2021: 37 · 2020: 31 · 2019: 24 · 2018: 21 · 2017: 14 · 2016: 5
FWCI
2.02
Type
journal article
Language
en
Open access
Locations
  • Drug Discoveries & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
HOMA-IR, insulin resistance, cut-off values, type 2 diabetes, diabetes diagnosis, Chinese population, primary prevention of diabetes
MeSH terms
Diabetes Mellitus, Type 2, Homeostasis, Humans, Insulin Resistance, Prediabetic State, Biomedical Research

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