The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Angiogenesis in refractory depression: A possible phenotypic target to avoid the blood brain barrier
Open accessAbstract
Major depressive syndrome (so-called depression) is a common but serious mental disease that causes low mood. Most patients are treatable, mainly because of high response rates for medicines such as selective serotonin-reuptake inhibitors (SSRIs). However, there are still a considerable number of patients with refractory or drug-resistant depression. On the other hand, recent findings suggest that angiogenesis, i.e., making new blood vessels, could have an important role in the recovery from depressive disorders, at least in part. It has been reported that the brain capillaries are physiologically capable of undergoing angiogenesis upon stimuli such as exercise and SSRIs seem to accelerate brain angiogenesis. Drugs targeting angiogenesis may possibly be another good concept. In addition, the blood brain barrier (BBB), which is a major obstacle for drug development for the central nervous system, would be circumvented. Here I summarize the reports that relate angiogenesis to a cure for major depression and discuss some of the potential molecular targets.
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“Nevertheless, angiogenesis seemed to be mediating the SSRI-induced upregulation of neurogenesis through VEGF (Yamada 2016).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Yamada 2016
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“Interestingly, VEGF can promote neurogenesis by stimulating endothelial cells in order to release other neurotrophic factors (Yamada 2016).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Yamada 2016
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Cites
Black, J. E., Isaacs, K. R., Anderson, B. J., Alcantara, A. A., & Greenough, W. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5568 · Cited by 1,161
Endothelial-pericyte interactions in angiogenesis
Gerhardt, H., & Betsholtz, C. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0745-x · Cited by 1,086
Leptin, the Product of Ob Gene, Promotes Angiogenesis
Bouloumié, A., Drexler, H. C. A., Lafontan, M., & Busse, R. (1998) · Circulation Research · doi:10.1161/01.res.83.10.1059 · Cited by 715
Schmidt, H. D., & Duman, R. S. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2aa8 · Cited by 662
Tsai, P. S., Kaufhold, J. P., Blinder, P., Friedman, B., Drew, P. J., Karten, H. J., Lyden, P. D., & Kleinfeld, D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3287-09.2009 · Cited by 601
Regulation of adult neurogenesis by antidepressant treatment
Duman, R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00358-x · Cited by 463
Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF
Cao, R., Brakenhielm, E., Wahlestedt, C., Thyberg, J., & Cao, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101564798 · Cited by 446
Curcumin Is an In Vivo Inhibitor of Angiogenesis
Arbiser, J. L., Klauber, N., Rohan, R. M., van Leeuwen, R., Huang, M., Fisher, C., Flynn, E. A., & Byers, H. R. (1998) · Molecular Medicine · doi:10.1007/bf03401744 · Cited by 401
Boldrini, M., Hen, R., Underwood, M. D., Rosoklija, G. B., Dwork, A. J., Mann, J. J., & Arango, V. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.024 · Cited by 348
Bråkenhielm, E., Cao, R., & Cao, Y. (2001) · The FASEB Journal · doi:10.1096/fj.01-0028fje · Cited by 334
Cited by
Sorted by citations
Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
Levy, M. J. F., Boulle, F., Steinbusch, H. W., van den Hove, D. L. A., Kenis, G., & Lanfumey, L. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4950-4 · Cited by 308
“Chronic stress in rats decreased the expression of VEGF and its receptor in the hippocampus (Heine et al. 2005).”
BackgroundInfluentialMalinovskaya, N. A., Komleva, Y. K., Salmin, V. V., Morgun, A. V., Shuvaev, А. N., Panina, Y. A., Boitsova, E. B., & Salmina, A. B. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00599 · Cited by 59
Kolshus, E., Ryan, K. M., Blackshields, G., Smyth, P. C., Sheils, O. M., & McLoughlin, D. M. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12821 · Cited by 43
Liang, M., Du, Y., Li, W., Yin, X., Ni, Y., Qie, A., LeBaron, T. W., Zhang, J., Chen, H., & Shi, H. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00082 · Cited by 25
Zhang, S., Lu, Y., Shi, W. Q., Ren, Y., Xiao, K., Chen, W., Li, L., & Zhao, J. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s370825 · Cited by 25
Retracted
Metadata
- Authors
- Yamada, M. K.
- Affiliations
- Isotope Science Center, The University of Tokyo (JP)
- Corresponding author
- Yamada, Maki K.
- ORCID
- Yamada, Maki K.
- Venue
- Drug Discoveries & Therapeutics
- Publisher
- International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)
- Published
- 2016
- Volume
- 10
- Issue
- 2
- Pages
- 74-78
- ISSN
- 1881-7831 (ISSN-L)
- 1881-784X
- OpenAlex
- W2337028414
- Cited by
- 16
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 1 · 2022: 2 · 2018: 4 · 2017: 2 · 2016: 2
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Drug Discoveries & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- angiogenesis, treatment-resistant depression, drug-resistant depression, blood-brain barrier, major depressive disorder, selective serotonin reuptake inhibitors, brain capillaries, physical activity, angiogenesis inhibitors, molecular targets, antidepressant drug development
- MeSH terms
- Animals, Blood-Brain Barrier, Depressive Disorder, Major, Major Depressive Disorder, Humans, Selective Serotonin Reuptake Inhibitors, Neovascularization, Physiologic, Depressive Disorder, Treatment-Resistant
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