The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Nephrotic syndrome unfavorable course correlates with downregulation of podocyte vascular endothelial growth factor receptor (VEGFR)‐2
Open accessAbstract
Idiopathic nephrotic syndrome (INS) in children is most commonly caused by primary glomerulopathies. Morphological lesions observed in INS might be secondary to inflammatory factors of mainly extra-renal origin. The vascular endothelial growth factor (VEGF) family is regarded as playing a crucial role in this pathomechanism. The aim of the present work was to analyze the possible relation between VEGF-C and VEGF receptor (VEGFR)-2 expressions at electron microscopy level in different INS cases. The study group comprised 18 children with minimal change disease (MCD), 30 patients diagnosed with diffuse mesangial proliferation (DMP) and 11 subjects with focal segmental glomerulosclerosis (FSGS). An indirect immunohistochemical assay employing monoclonal anti-VEGF-C and anti-VEGFR-2 antibodies was applied in the study. The immunohistochemical expression of VEGF-C within podocyte cytoplasm was significantly increased in DMP subjects who were resistant to steroids and in all FSGS patients compared to MCD children and controls (p 〈 0.05). VEGF-C over-expression in these cases was followed by downregulation of VEGFR-2. Nephrotic syndrome progression correlates with the downregulation of podocyte VEGFR-2. For this reason, decreased VEGFR-2 expression in the podocyte processes of children with idiopathic nephrotic syndrome might be regarded as a potent factor of unfavorable prognosis.
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“The positive role of VEGF and its effect on angiogenesis and vascular permeability is supported by the evidence that treatment with anti‐VEGF in renal cancer aggravates renal failure.45, 46”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [45]
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“Nephrotic syndrome | ↓ to ↓↓↓ | ↑ to↑↑↑ | ↑ to↑↑↑ | ↓ to ↓↓ | ↓ to ↓↓↓ | ↑ to↑↑↑ | ↑44, 45 | Albumin mass↓ due to protein loss and shortened half‐life”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [45]
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Karkkainen, M. J., Haiko, P., Sainio, K., Partanen, J. M., Taipale, J., Petrova, T. V., Jeltsch, M., Jackson, D. G., Talikka, M., Rauvala, H., et al. (2003) · Nature Immunology · doi:10.1038/ni1013 · Cited by 1,441
Achen, M. G., Jeltsch, M., Kukk, E., Mäkinen, T., Vitali, A. A., Wilks, A. F., Alitalo, K. K., & Stacker, S. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.548 · Cited by 1,203
The biology of vascular endothelial growth factors
Tammela, T., Enholm, B., Alitalo, K. K., & Paavonen, K. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.002 · Cited by 859
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tammela, T., Zarkada, G., Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R., et al. (2008) · Nature · doi:10.1038/nature07083 · Cited by 834
Proteolytic processing regulates receptor specificity and activity of VEGF‐C
Joukov, V., Sorsa, T., Kumar, V., Jeltsch, M., Claesson, L., Cao, Y., Saksela, O., Kalkkinen, N., & Alitalo, K. K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3898 · Cited by 789
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
Lohela, M. K., Bry, M., Tammela, T., & Alitalo, K. K. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.12.012 · Cited by 752
Kukk, E., Lymboussaki, A., Taira, S., Kaipainen, A., Jeltsch, M., Joukov, V., & Alitalo, K. K. (1996) · Development · doi:10.1242/dev.122.12.3829 · Cited by 687
Biology of vascular endothelial growth factors
Roy, H., Bhardwaj, S., & Ylä‐Herttuala, S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.087 · Cited by 549
PATHOLOGY OF THE NEPHROTIC SYNDROME IN CHILDREN
Churg, J., Habib, R., & White, R. R. (1970) · The Lancet · doi:10.1016/s0140-6736(70)91905-7 · Cited by 523
The role of the VEGF-C/VEGFR-3 axis in cancer progression
Su, J.-L., Yen, C.-J., Chen, P.-S., Chuang, S.-E., Hong, C.-C., Kuo, I.-H., Chen, H.-Y., Hung, M., & Kuo, M.-L. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603487 · Cited by 257
Cited by
Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448
Metadata
- Authors
- Ostalska-Nowicka, D., Malinska, A., Zabel, M., Witkiewicz, W., & Nowicki, M.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Venue
- Folia Histochemica et Cytobiologica
- Publisher
- VM Media SP. zo.o VM Group SK
- Published
- 2011-10-28
- Volume
- 49
- Issue
- 3
- Pages
- 472-478
- ISSN
- 0015-5586 (ISSN-L)
- 1897-5631
- 0239-8508
- OpenAlex
- W1996549952
- Cited by
- 10
- References
- 31
- Citations by year
- 2021: 3 · 2019: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Folia Histochemica et Cytobiologica (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Keywords
- nephrotic syndrome, idiopathic nephrotic syndrome, podocytes, VEGFR2, VEGF-C, vascular endothelial growth factor, minimal change disease, focal segmental glomerulosclerosis, steroid resistance, prognosis, children, glomerular disease
- MeSH terms
- Adolescent, Child, Child, Preschool, Female, Humans, Immunohistochemistry, Male, Nephrotic Syndrome, Signal Transduction, Down-Regulation, Disease Progression, Protein Isoforms, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor C, Podocytes
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