Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes?
Open accessAbstract
OBJECTIVES: To determine whether pregnant women who have reactive hypoglycemia during the 100 g oral glucose toler-ance test (OGTT) are at an increased risk of poor pregnancy outcomes. MATERIAL AND METHODS: We retrospectively analyzed perinatal data from 413 women who underwent a 3 h OGTT at 24-28 weeks of gestation and gave birth in our clinics between January 2012 and December 2014. RESULTS: According to OGTT results, the majority of the subjects were normoglycemic (n = 316, 76.5%), while 49 (11.9%) were diagnosed with gestational diabetes, and 33 (8.0%) had single high glucose values. Reactive hypoglycemia was de-tected in only 15 patients (3.6%). The mean age of the women in the reactive hypoglycemia group was significantly lower than that of the women in the gestational diabetes and single high glucose value groups (26.4 ± 4.4 years, 31.4 ± 5.4 years, and 31.8 ± 4.3 years, respectively; p < 0.05). The newborns of the women in the reactive hypoglycemia group had higher rates of APGAR scores < 7, increased admission to the neonatal intensive care unit (NICU), and lower birth weights compared with the other groups (p < 0.001, p < 0.001, and p = 0.009, respectively). CONCLUSION: Reactive hypoglycemia during the 3 h 100 g OGTT is significantly associated with low APGAR scores, low birth weights, and prenatal admission to the NICU. Therefore, pregnant women who develop hypoglycemia during the 100 g OGTT performed at 24-28 weeks of gestation should receive attentive follow-up care to decrease the possibility of adverse perinatal outcomes.
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The exact definition of hypoglycemia is not uniform in the literature and varies according to glucose values (45-60 mg/dL) and accompanying symptoms.
“The exact definition of hypoglycemia is not uniform in the literature and varies according to the glucose values (45–60 mg/dL) and accompanying symptoms [3,4].”
From Hypoglycemia in Oral Glucose Tolerance Test during Pregnancy and Risk for Type 2 Diabetes—A Five-Year Cohort Study (2024) · cites this paper as [4]
The Introduction says there is no precise glucose cut-off that predicts hypoglycemic symptoms and that reports use 45–50 mg/dL as indicative of reactive hypoglycemia. This supports variation in thresholds and the relevance of symptoms, but not the claimed upper value of 60 mg/dL. The Study groups section uses a 45 mg/dL cut-off; page numbers were unavailable in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredPrevious studies investigating the association between reactive hypoglycemia and pregnancy outcomes have conflicting results.
“Previous studies investigated the association between reactive hypoglycemia and pregnancy outcomes with conflicting results [4,5,6,7].”
From Hypoglycemia in Oral Glucose Tolerance Test during Pregnancy and Risk for Type 2 Diabetes—A Five-Year Cohort Study (2024) · cites this paper as [4]
The prevalence of hypoglycemia during oGTT in pregnancy ranges between 3.6% and 11.3% in different reports.
“Accordingly, the prevalence of hypoglycemia during oGTT in pregnancy ranges between 3.6% and 11.3% in different reports [4,5,6,7].”
From Hypoglycemia in Oral Glucose Tolerance Test during Pregnancy and Risk for Type 2 Diabetes—A Five-Year Cohort Study (2024) · cites this paper as [4]
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Haggiag, N., Rotman, M., Hallak, M., Toledano, Y., Gabbay-Benziv, R., & Maor-Sagie, E. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133806 · Cited by 4 · see citing works
“The exact definition of hypoglycemia is not uniform in the literature and varies according to the glucose values (45–60 mg/dL) and accompanying symptoms [3,4].”
BackgroundResultInfluential
- Authors
- Delibas, I. B., Tanriverdi, S., & Cakmak, B.
- Venue
- Ginekologia Polska
- Publisher
- VM Media SP. zo.o VM Group SK
- Published
- 2018-01-31
- Volume
- 89
- Issue
- 1
- Pages
- 25-29
- ISSN
- 0017-0011 (ISSN-L)
- 2543-6767
- OpenAlex
- W2786480046
- Cited by
- 26
- References
- 4
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 2 · 2023: 2 · 2021: 6 · 2020: 4 · 2019: 2
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Ginekologia Polska (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Via Medica Journals (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- reactive hypoglycemia, oral glucose tolerance test, perinatal outcomes, gestational diabetes mellitus, pregnancy, neonatal intensive care admission, Apgar score, low birth weight, maternal age
- MeSH terms
- Adult, Apgar Score, Birth Weight, Female, Glucose Tolerance Test, Humans, Hypoglycemia, Infant, Newborn, Infant, Newborn, Diseases, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Retrospective Studies
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