Differences in Gamma-Glutamyl Transferase and High-Sensitivity C-Reactive Protein Levels Between Type 2 Diabetes Mellitus with and without Vascular Complications

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a metabolic disease that causes microvascular and macrovascular complications and increases mortality. Oxidative stress and inflammation play a role in the pathogenesis of (T2DM). Gamma-glutamyl transferase (GGT) and high-sensitivity C-Reactive Protein (hs-CRP) levels as oxidative stress and inflammation markers help detect the high risk of developing T2DM complications. Objectives: Analyzing the differences in GGT and hs-CRP levels between T2DM with and without vascular complications predicts the sensitivity and specificity for the detection of T2DM vascular complications. Methods: The cross-sectional study involved 19 patients with vascular complications of T2DM and 19 patients with T2DM without complications. Using patient serum samples, GGT and hs-CRP levels were measured using the TMS24i device. Results: The T2DM vascular complications group increased GGT and hs-CRP values. GGT and hs-CRP levels between T2DM with and without vascular complications were significant. The macrovascular (CHD) group had a higher GGT value than the microvascular group, there was a substantial difference in GGT between the two research subjects. On the other hand, there was no significant difference in hs-CRP. Logistic regression analysis found that the duration of T2DM and GGT influenced the risk of T2DM vascular complications. Analysis (ROC) showed GGT had (AUC=0.691) and hs-CRP (AUC=0.706). Conclusions: GGT plays a role in risk detection (CHD) compared to microvasculature. Significant differences in GGT and hs-CRP between T2DM with and without vascular complications and vascular complications of T2DM increase the values of GGT and hs-CRP