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Post Moderna Vaccine associated acute disseminated encephalomyelitis (ADEM) - A case report.
Open accessAbstract
Due to pervasive pandemic of SARS CoV-2 the reports of rare neurological complications have turned up out of the ordinary. The public health concerns are raised due to SARS-CoV-2 infection and vaccinations as this recent pandemics has set the development and deployment of vaccines at large scale. The randomized controlled trials being carried were underpowered to foresee these rare adverse effects. Amongst other neurological complications acute disseminated encephalomyelitis ADEM has been reported with vaccination for SARS-CoV-2. Herein, we report a patient with a unique presentation of ADEM, a severe neuroinflammatory disorder developed shortly after mRNA based Moderna vaccine for SARS-CoV-2.
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“Although some case reports have suggested a possible association between COVID-19 vaccination and ADEM, there was no consistent pattern in terms of vaccine or timing following vaccination, and larger epidemiological studies have not confirmed any potential association [41 -44].”
From COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals (2024) · cites this paper as [44]
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Research works printed but not linked: 10
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- Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis. 2020;94:55-8.
- Benninger F, Steiner I. Non-infectious mechanisms of neurological damage due to infection. J Neurol Sci. 2021;431:120057.
- Rinaldi V, Bellucci G, Romano A, Bozzao A, Salvetti M. ADEM after ChAdOx1 nCoV-19 vaccine: A case report. Mult Scler. 2022;28(7):1151-4.
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- Wang CX. Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient. Paediatr Drugs. 2021;23(3):213-21
- Vogrig A, Janes F, Gigli GL, Curcio F, Negro ID, D'Agostini S, et al. Acute disseminated encephalomyelitis after SARS-CoV-2 vaccination. Clin Neurol Neurosurg. 2021;208:106839.
- Ismail, II, Salama S. A systematic review of cases of CNS demyelination following COVID-19 vaccination. J Neuroimmunol. 2022;362:577765.
- Patone M, Handunnetthi L, Saatci D, Pan J, Katikireddi SV, Razvi S, et al. Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection. Nat Med. 2021;27(12):2144-53.
Cited by
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Faksova, K., Walsh, D., Jiang, Y., Griffin, J., Phillips, A., Gentile, A., Kwong, J. C., Macartney, K., Naus, M., Grange, Z., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.01.100 · Cited by 212
“Although some case reports have suggested a possible association between COVID-19 vaccination and ADEM, there was no consistent pattern in terms of vaccine or timing following vaccination, and larger epidemiological studies have not confirmed any potential association [41 – 44].”
Result
Metadata
- Authors
- Khan, S., Khan, S., Waqar, Z., Mobeen, H., Khan, N., & Hassan, M.
- Affiliations
- Pakistan Institute of Medical Sciences (PK)
- Venue
- Pakistan Journal of Neurological Sciences
- Publisher
- Pakistan Society of Neurology
- Published
- 2022-10-18
- Volume
- 17
- Issue
- 01
- ISSN
- 1990-6269 (ISSN-L)
- 1990-813X
- OpenAlex
- W4310685430
- Cited by
- 2
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pakistan Journal of Neurological Sciences (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- acute disseminated encephalomyelitis, COVID-19 vaccine adverse events, Moderna vaccine, mRNA vaccines, SARS-CoV-2, post-vaccination neurological complications, neuroinflammation
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