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Chronic Opioid Use is a Risk Factor for the Development of Central Sleep Apnea and Ataxic Breathing
Open accessAbstract
Background Chronic opioid therapy for pain management has increased dramatically without adequate study of potential deleterious effects on breathing during sleep.Methods A retrospective cohort study comparing 60 patients taking chronic opioids matched for age, sex, and body mass index with 60 patients not taking opioids was conducted to determine the effect of morphine dose equivalent on breathing patterns during sleep.Results The apnea-hypopnea index was greater in the opioid group (43.5/h vs 30.2/h, p < .05) due to increased central apneas (12.8/h vs 2.1/h; p < .001). Arterial oxygen saturation (SpO2) in the opioid group was significantly lower during both wakefulness (difference 2.1%, p < .001) and non-rapid eye movement (NREM) sleep (difference 2.2%, p < .001) but not during rapid eye movement (REM) sleep (difference 1.2%) than in the nonopioid group. Within the opioid group, and after controlling for body mass index, age, and sex, there was a dose-response relationship between morphine dose equivalent and apnea-hypopnea (p < .001), obstructive apnea (p < .001), hypopnea (p < .001), and central apnea indexes (p < .001). Body mass index was inversely related to apnea-hypopnea index severity in the opioid group. Ataxic or irregular breathing during NREM sleep was also more prevalent in patients who chronically used opioids (70% vs 5.0%, p < .001) and more frequent (92%) at a morphine dose equivalent of 200 mg or higher (odds ratio = 15.4, p = .017).Conclusions There is a dose-dependent relationship between chronic opioid use and the development of a peculiar pattern of respiration consisting of central sleep apneas and ataxic breathing. Although potentially significant, the clinical relevance of these observations remains to be established.
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“By contrast, opioid analgesics produce deleterious effects on sleep architecture, including reductions in slow wave sleep and promotion of sleep apnea.157, 158”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [157]
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Cites
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Hobson, J. A. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90021-2 · Cited by 5,215
McNicholas, W. T., Strohl, K. P., White, D. P., Levy, P. A., Schmidt, W., Wheatley, J. R., Redline, S. S., Carley, D. W., Buysse, D. J., Young, T. B., et al. (1999) · PubMed · Cited by 3,665
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243
Opioid therapy for chronic nonmalignant pain: a review of the critical issues
Portenoy, R. K. (1996) · Journal of Pain and Symptom Management · doi:10.1016/0885-3924(95)00187-5 · Cited by 532
Trends in Medical Use and Abuse of Opioid Analgesics
Joranson, D. E. (2000) · JAMA · doi:10.1001/jama.283.13.1710 · Cited by 505
Central Sleep Apnea in Stable Methadone Maintenance Treatment Patients
Wang, D., Teichtahl, H., Drummer, O. H., Goodman, C., Cherry, G., Cunnington, D., & Kronborg, I. (2005) · CHEST Journal · doi:10.1378/chest.128.3.1348 · Cited by 321
Donner, B., Zenz, M. W., Tryba, M., & Strumpf, M. (1996) · Pain · doi:10.1016/0304-3959(95)00180-8 · Cited by 260
Mercadante, S., Casuccio, A., Fulfaro, F., Groff, L., Boffi, R., Villari, P., Gebbia, V., & Ripamonti, C. I. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.11.2898 · Cited by 250
White, D. P. (1985) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30983-x · Cited by 234
Flagged first, then by citations
4 of the 35 references couldn’t be matched to a known paper.
Research works printed but not linked: 8
- Hare BD, Lipman AG. Uses and misuses of medication in the management of chronic, noncancer pain. In: BD Hare, PG Fine, eds. Problems in Anesthesia, Philadelphia: JB Lippincott; 1990:577–94.
- McCaffery M, Pasero C. Pain Clinical Manual, 2nd ed, St Louis: Mosby; 1999.
- Biot, MC. Contribution a l’ètude de phènomène respiratoire de Cheyne-Stokes. Lyon Mèd1876;23:517–28,561–7.
- Ruth, WE. Examination of the chest, lungs, and pulmonary system. In: Mahlon H, Manning, RT Major’s physical diagnosis, 8th ed. Philadelphia: WB Saunders; 1975:318–9.
- Bowes G, Phillipson, EA. Arousal response to respiratory stimuli during sleep. In: Saunders, NA, Sullivan CE, eds. Sleep and Breathing. New York: Marcel Dekker, 1984:131–61.
- American Academy of Sleep Medicine. Crosswalk from ICSD-2 to ICD-9. Available at http://www.aasmnet.org/PDF/CrosswalkCard.pdf. 2006.
- Dhawan R, Lieno C, Chesson A, Desai S, et al. Opioid-induced sleep breathing abnormalities. Diagnostic and therapeutic features, dose dependant phenomenon. Sleep 2004,27:206–7.
- Porucznik, CA, Farney RJ, Walker,JM, Rolfs RT, Grey, T. Increased mortality rate associated with prescribed opioid medications: is there a link with sleep disordered breathing? Presented at 15th Annual Congress, European Respiratory Society, Copenhagen, Denmark, 20 Sep 2005, Eur Respir J 2005;26:596.
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Weighing the balance: how analgesics used in chronic pain influence sleep?
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Alternative Approaches to Treatment of Central Sleep Apnea
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Ermer, S. C., Farney, R. J., Johnson, K. B., Orr, J. A., Egan, T. D., & Brewer, L. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004498 · Cited by 26
Self-citationThe relationship between sleep and opioids in chronic pain patients
Frers, A., Shaffer, J. A., Edinger, J. D., & Wachholtz, A. (2021) · Journal of Behavioral Medicine · doi:10.1007/s10865-021-00205-1 · Cited by 29
Predictive factors for sleep apnoea in patients on opioids for chronic pain
Chung, F. F., Wong, J., Bellingham, G. A., Lebovic, G., Singh, M., Waseem, R., Peng, P., George, C. F., Furlan, A. D., Bhatia, A., et al. (2019) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2019-000523 · Cited by 26
Yarlas, A. S., Miller, K., Wen, W., Lynch, S. Y., Ripa, S. R., Pergolizzi, J. V., & Raffa, R. B. (2015) · Pain Practice · doi:10.1111/papr.12281 · Cited by 25
Lacy, B. E., & Cangemi, D. J. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002887 · Cited by 27
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Clinical heterogeneity of patients with complex sleep apnea syndrome
Kuźniar, T. J., Kasibowska-Kuźniar, K., Ray, D. W., & Freedom, T. (2013) · Sleep And Breathing · doi:10.1007/s11325-013-0825-4 · Cited by 24
A Review of Opioids for In-Hospital Pain Management
Viscusi, E. R., & Pappagallo, M. (2012) · Hospital Practice · doi:10.3810/hp.2012.02.955 · Cited by 24
Panossian, L. A., & Daley, J. T. (2013) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000427211.98305.c6 · Cited by 26
Fentanyl effects on respiratory neuron activity in the dorsolateral pons
Saunders, S. E., Baekey, D. M., & Levitt, E. S. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00113.2022 · Cited by 23
Rethinking the role of opioids in the outpatient management of chronic nonmalignant pain
Provenzano, D. A., & Viscusi, E. R. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.921610 · Cited by 22
Selim, B. J., & Ramar, K. (2016) · Expert Review of Medical Devices · doi:10.1080/17434440.2016.1218759 · Cited by 22
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Congestive Heart Failure and Central Sleep Apnea
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High-dose opioids for chronic non-cancer pain: an overview of Cochrane Reviews
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Nguyen, C., Kim, J., Grunstein, R. R., Thamrin, C., & Wang, D. (2016) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.5702 · Cited by 20
Jaoude, P., Lal, A. A., Vermont, L. N., Porhomayon, J., & El-Solh, A. (2016) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6046 · Cited by 20
High-dose opioids for chronic non-cancer pain: an overview of Cochrane reviews
Els, C., Hagtvedt, R., Kunyk, D., Sonnenberg, B., Lappi, V. G., & Straube, S. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012299 · Cited by 20
Burgraff, N. J., Baertsch, N. A., & Ramirez, J. (2023) · The Journal of Physiology · doi:10.1113/jp285163 · Cited by 19
Maiolino, G., Bisogni, V., Silvani, A., Pengo, M. F., Lombardi, C., & Parati, G. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd-cus-2020-014 · Cited by 22
Acute and long-term effects of acetazolamide in presumed high loop gain sleep apnea
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Tentindo, G. S., Fishman, S. M., Li, C., Wang, Q., & Brass, S. D. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s167658 · Cited by 19
Options for treating postherpetic neuralgia in the medically complicated patient
Bruckenthal, P., & Barkin, R. L. (2013) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s47138 · Cited by 18
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Science supporting the art of medicine: improving the management of breathlessness
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A Contemporary Medicolegal Analysis of Outpatient Medication Management in Chronic Pain
Abrecht, C. R., Brovman, E. Y., Greenberg, P., Song, E., Rathmell, J. P., & Urman, R. D. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002499 · Cited by 17
Rao, H., & THOMAS, R. J. (2013) · Current Treatment Options in Neurology · doi:10.1007/s11940-013-0260-7 · Cited by 17
Pavlova, M. K., & Sheikh, L. (2011) · Seminars in Neurology · doi:10.1055/s-0031-1293539 · Cited by 18
Good, P. D., Pinkerton, C., Bowler, S., Craig, J., & Hardy, J. R. (2017) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2017.11.026 · Cited by 17
Opioid-Induced Central Sleep Apnea
Javaheri, S., & Randerath, W. J. (2014) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2013.10.003 · Cited by 16
Priou, P., d’Ortho, M., Damy, T., Davy, J., Gagnadoux, F., Gentina, T., Meurice, J.-C., Pépin, J., Tamisier, R., & Philippe, C. (2015) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2015.09.007 · Cited by 16
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Metadata
- Authors
- Walker, J. M., Farney, R. J., Rhondeau, S. M., Boyle, K. M., Valentine, K., Cloward, T. V., & Shilling, K. C.
- Affiliations
- Intermountain Healthcare (US)
- Corresponding author
- Walker, James M.
- Venue
- Journal of Clinical Sleep Medicine
- Published
- 2007-08-15
- Volume
- 3
- Issue
- 5
- Pages
- 455-461
- ISSN
- 1550-9389 (ISSN-L)
- 1550-9397
- PMC
- PMC1978331
- OpenAlex
- W159756581
- Cited by
- 419
- References
- 35
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 17 · 2023: 14 · 2022: 15 · 2021: 23 · 2020: 25 · 2019: 18 · 2018: 19 · 2017: 25 · 2016: 33 · 2015: 37 · 2014: 34 · 2013: 20 · 2012: 27
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Sleep Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- chronic opioid use, central sleep apnea, apnea-hypopnea index, arterial oxygen saturation, body mass index, obstructive apnea, hypopnea, sleep-disordered breathing, opioid side effects
- MeSH terms
- Adult, Analgesics, Opioid, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Pain, Respiration, Retrospective Studies, Severity of Illness Index, Cohort Studies, Body Mass Index, Polysomnography, Sleep Apnea, Obstructive, Sleep Apnea, Central
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