Cellular Aging and Restorative Processes: Subjective Sleep Quality and Duration Moderate the Association between Age and Telomere Length in a Sample of Middle-Aged and Older Adults
Open accessAbstract
STUDY OBJECTIVES: To examine whether subjective sleep quality and sleep duration moderate the association between age and telomere length (TL). DESIGN: Participants completed a demographic and sleep quality questionnaire, followed by a blood draw. SETTING: Social Neuroscience Laboratory. PARTICIPANTS: One hundred fifty-four middle-aged to older adults (age 45-77 y) participated. Participants were excluded if they were on immunosuppressive treatment and/or had a disease with a clear immunologic (e.g., cancer) component. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Subjective sleep quality and sleep duration were assessed using the Pittsburgh Sleep Quality Index (PSQI) and TL was determined using peripheral blood mononuclear cells (PBMCs). There was a significant first-order negative association between age and TL. Age was also negatively associated with the self-reported sleep quality item and sleep duration component of the PSQI. A significant age × self-reported sleep quality interaction revealed that age was more strongly related to TL among poor sleepers, and that good sleep quality attenuated the association between age and TL. Moreover, adequate subjective sleep duration among older adults (i.e. greater than 7 h per night) was associated with TL comparable to that in middle-aged adults, whereas sleep duration was unrelated to TL for the middle-aged adults in our study. CONCLUSIONS: The current study provides evidence for an association between sleep quality, sleep duration, and cellular aging. Among older adults, better subjective sleep quality was associated with the extent of cellular aging, suggesting that sleep duration and sleep quality may be added to a growing list of modifiable behaviors associated with the adverse effects of aging.
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Age and self-reported sleep quality interact in predicting telomere length in older adults.
“age and self-reported sleep quality interact in predicting telomere length (Cribbet et al, 2014).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Cribbet et al, 2014
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References 59 · Cited by 93
Research works printed but not linked: 5
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- Irwin MR, Wang M, Ribeiro D, et al. Sleep loss activates cellular inflammatory signaling. Biol Psychiatry 2008;64:538-40.
- Barcelo A, Pierola J, Lopez-Escribano H, et al. Telomere shortening in sleep apnea syndrome. Respir Med 2010;104:1225-9.
- Kim J, Lee S, Bhattacharjee R, Khalyfa A, Kheirandish-Gozal L, Gozal D. Leukocyte telomere length and plasma catestatin and myeloid-related protein 8/14 concentrations in children with obstructive sleep apnea. Chest 2010;138:91-9.
- Authors
- Cribbet, M. R., Carlisle, M., Cawthon, R. M., Uchino, B. N., Williams, P. G., Smith, T. W., Gunn, H. E., & Light, K. C.
- Affiliations
- University of Utah (US)
- Corresponding author
- Cribbet, Matthew R.
- ORCID
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01-01
- Volume
- 37
- Issue
- 1
- Pages
- 65-70
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC3902883
- OpenAlex
- W2323480284
- Cited by
- 93
- References
- 59
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 11 · 2022: 6 · 2021: 9 · 2020: 7 · 2019: 11 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 7 · 2014: 2
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R21AG029239)
- National Center for Research Resources (C06RR011234, C06-RR-11234, UL1RR025764)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- cellular aging, telomere length, subjective sleep quality, sleep duration, aging, middle-aged adults, older adults, peripheral blood mononuclear cells
- MeSH terms
- Aged, Aging, Female, Humans, Sleep Initiation and Maintenance Disorders, Leukocytes, Mononuclear, Male, Middle Aged, Surveys and Questionnaires, Sleep, Telomere, Cellular Senescence, Self Report
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