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Cited by 31Advanced Drug Delivery SystemsAdvancements in Transdermal Drug DeliveryHydrogels: synthesis, properties, applications

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Design Expert Assisted Formulation of Topical Bioadhesive Gel of Sertaconazole Nitrate

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Pande, Vishal, Patel, Samir, Patil, Vijay, Sonawane, Raju·2014·Tabriz University of Medical Sciences
DOI 10.5681/apb.2014.019PMC PMC3915811
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Abstract

Purpose: The objective of this work was to develop a bioadhesive topical gel of sertaconazole nitrate with the help of response-surface approach. Methods: Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Carbapol 934 = X1) and Sodium carboxymethylcellulose (NaCMC) = X2)] on the bioadhesive character of gel, rheological property of gel (consistency index), and in-vitro drug release. The best model was selected to fit the data. Results: Mathematical equation was generated by Design Expert® software for the model which assists in determining the effect of independent variables. Response surface plots were also generated by the software for analyzing effect of the independent variables on the response. The effect of formulation variables on the product characteristics can be easily predicted and precisely interpreted by using a 3-level factorial design and generated quadratic mathematical equations. Conclusion: On the basis of product characteristics viscosity, bioadhesiveness, permeation study, in-vitro release, in-vivo studies, TPA and spreadability it can be concluded that the best batch of topical bioadhesive gel of Sertaconazole nitrate would be with 1% Carbopol 934 and 1% NaCMC.

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Research works printed but not linked: 20

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Metadata

Authors
Pande, V., Patel, S., Patil, V., & Sonawane, R.
ORCID
Venue
Tabriz University of Medical Sciences
Publisher
Tabriz University of Medical Sciences
Published
2014
Volume
4
Issue
2
Pages
121-30
DOI
10.5681/apb.2014.019
PMC
PMC3915811
OpenAlex
W2119765837
Cited by
31
References
0
Citations by year
2026: 5 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 1 · 2016: 2 · 2015: 4 · 2014: 2
FWCI
1.49
Type
journal article
Language
en
Open access
Locations
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Tabriz University of Medical Sciences
  • PubMed
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords
sertaconazole nitrate, Carbopol 934, carboxymethyl cellulose, response surface methodology, factorial design, gel rheology, consistency index, in vitro drug release, spreadability, antifungal formulation

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