The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Epstein-Barr virus and nasopharyngeal carcinoma
Open accessAbstract
Since its discovery 50 years ago, Epstein-Barr virus (EBV) has been linked to the development of cancers originating from both lymphoid and epithelial cells. Approximately 95% of the world's population sustains an asymptomatic, life-long infection with EBV. The virus persists in the memory B-cell pool of normal healthy individuals, and any disruption of this interaction results in virus-associated B-cell tumors. The association of EBV with epithelial cell tumors, specifically nasopharyngeal carcinoma (NPC) and EBV-positive gastric carcinoma (EBV-GC), is less clear and is currently thought to be caused by the aberrant establishment of virus latency in epithelial cells that display premalignant genetic changes. Although the precise role of EBV in the carcinogenic process is currently poorly understood, the presence of the virus in all tumor cells provides opportunities for developing novel therapeutic and diagnostic approaches. The study of EBV and its role in carcinomas continues to provide insight into the carcinogenic process that is relevant to a broader understanding of tumor pathogenesis and to the development of targeted cancer therapies.
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Cites
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Cited by
Translational genomics and recent advances in oral squamous cell carcinoma
Chai, A. W. Y., Lim, K. P., & Cheong, S. C. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.011 · Cited by 298
RETRACTED ARTICLE: Vasculogenic mimicry formation in EBV-associated epithelial malignancies
Xiang, T., Lin, Y.-X., Ma, W., Zhang, H.-J., Chen, K.-M., He, G.-P., Zhang, X., Xu, M., Feng, Q.-S., Chen, M.-Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07308-5 · Cited by 172
RetractedTumor CTLA-4 overexpression predicts poor survival in patients with nasopharyngeal carcinoma
Huang, P.-Y., Guo, S.-S., Zhang, Y., Lu, J.-B., Chen, Q.-Y., Tang, L.-Q., Zhang, L., Liu, L.-T., Zhang, L., & Mai, H.-Q. (2016) · Oncotarget · doi:10.18632/oncotarget.7421 · Cited by 96
Metadata
- Authors
- Young, L. S., & Dawson, C. W.
- Venue
- Chinese Journal of Cancer
- Published
- 2014-11-21
- Volume
- 33
- Issue
- 12
- Pages
- 581-90
- ISSN
- 1000-467X (ISSN-L)
- 1944-446X
- OpenAlex
- W1965947832
- Cited by
- 253
- References
- 59
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- Young, L. S., & Dawson, C. W. (2014). Epstein-Barr virus and nasopharyngeal carcinoma. Chinese Journal of Cancer. https://doi.org/10.5732/cjc.014.10197
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
