Preoperative Platelet to Albumin Ratio Predicts Outcome of Patients with Non-Small-Cell Lung Cancer
Open accessAbstract
OBJECTIVE: The purpose of this study was to evaluate the predictive power of the platelet to albumin ratio (PAR) on survival outcomes of patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: In all, 198 patients with NSCLC were recruited. The X-tile software was performed to identify the optimal cutoff values for PAR, platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR). The Kaplan-Meier method, univariate and multivariate analyses Cox regression were used to analyze the prognostic factors for overall survival (OS). RESULTS: (P <0.001), PLR > 147.7 (P <0.001), and NLR >3.9 (P = 0.007) were associated with poor OS. Multivariate analyses found that PAR was an independent predictor in NSCLC patients (hazard ratio [HR]: 4.604, 95% confidence interval [CI]: 2.557-8.290, P <0.001). CONCLUSION: Preoperative PAR is a useful and potential prognostic biomarker in NSCLC patients who have received primary resection.
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PAR is a biomarker for inflammatory status and has been shown effective in predicting inflammation states of affective disorders.
“The platelet-to-albumin ratio (PAR) was first proposed to assess cancer prognostic and considered as a biomarker for inflammatory status,12 which has been shown to be effective in predicting inflammation states of affective disorders in previous study.13”
From Albumin and Associated Biomarkers in Severe Neuropsychiatric Disorders: Acute-Phase Schizophrenia and Bipolar Disorder (2023) · cites this paper as [12]
PAR is a combined indicator of inflammation and nutritional status and a useful prognostic biomarker for various cancers.
“Platelet albumin ratio (PAR) is a combined indicator of inflammation and nutritional status and has been shown to be a useful and potentially prognostic biomarker for various cancers.12”
From Albumin and Associated Biomarkers in Severe Neuropsychiatric Disorders: Acute-Phase Schizophrenia and Bipolar Disorder (2023) · cites this paper as [12]
PAR was originally studied in cancer and is considered a clinical indicator of inflammatory status.
“The platelet to albumin ratio (PAR) was originally studied in cancer and is considered as a clinical indicator of inflammatory status [36].”
From Characteristics of platelet-associated parameters and their predictive values in Chinese patients with affective disorders (2022) · cites this paper as [36]
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- Authors
- Guo, M., Sun, T., Zhao, Z., & Ming, L.
- Affiliations
- First Affiliated Hospital of Zhengzhou University (CN)
- Corresponding author
- Ming, Liang
- Venue
- Annals of Thoracic and Cardiovascular Surgery
- Published
- 2021
- Volume
- 27
- Issue
- 2
- Pages
- 84-90
- ISSN
- 1341-1098 (ISSN-L)
- 2186-1005
- PMC
- PMC8058543
- OpenAlex
- W3104577155
- Cited by
- 46
- References
- 30
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 9 · 2021: 5
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Annals of Thoracic and Cardiovascular Surgery (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Keywords
- platelet-to-albumin ratio, non-small cell lung cancer, prognostic factors, overall survival, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, surgical resection
- MeSH terms
- Serum Albumin, Human, Adolescent, Adult, Aged, Aged, 80 and over, Blood Platelets, Carcinoma, Non-Small-Cell Lung, Female, Humans, Lung Neoplasms, Male, Middle Aged, Platelet Count, Pneumonectomy, Predictive Value of Tests, Retrospective Studies, Risk Factors, Time Factors, Biomarkers, Treatment Outcome, Risk Assessment, Young Adult
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