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Cited by 14Stress Responses and CortisolMemory and Neural MechanismsNeuropeptides and Animal Physiology

The Role of the Amygdala in Regulating the Hypothalamic-Pituitary-Adrenal Axis

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Weidenfeld, Joseph, Ovadia, Haim·2017·The Amygdala - Where Emotions Shape Perception, Learning and Memories
DOI 10.5772/67828
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Abstract

We investigated the regulatory role of the amygdala upon the function of the hypothalamic-pituitary-adrenal (HPA) axis as measured by median eminence corticotrophin releasing hormone (CRH) content and serum levels of adrenocorticotrophic hormone (ACTH) and corticosterone. Our findings showed that (1) lesions of the central amygdala inhibited the HPA axis responses to a variety of stressful stimuli. (2) Depletion of norepinephrine or serotonin in the amygdala and hypothalamus and local injections of norepinephrine and serotonin receptor antagonists into the central amygdala inhibited the HPA axis responses to neural stress. Norepinephrine and serotonin agonists injected into the amygdala caused an increase in HPA axis activity. The activation of the amygdala facilitated the in vivo release of serotonin from the paraventricular nucleus following electrical stimulation of the brainstem raphe nuclei. (3) Electrical stimulation of the amygdala impaired the glucocorticoid negative feedback action following neural stressful stimuli probably via a decrease in hippocampal corticosteroid receptors.

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  • Stimulation to central nuclei of the amygdala causes overexpression of CRH resulting in an increase in HPA axis activity.

    “Stimulation to central nuclei causes overexpression of CRH resulting in an increase in HPA axis activity (68–70).”

    From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [70]

    Section 2.1 (Neural stimuli; page not provided) links input from the central amygdala to CRH release and an increased HPA-axis response. It reports CRH release, not CRH overexpression, and does not establish that direct stimulation of the central nucleus causes overexpression. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 49

  1. De Kloet, E.R., et al., Brain corticosteroid receptor balance in health and disease. Endocr Rev, 1998. 19(3): pp. 269-301.
  2. Antoni, F.A., Hypothalamic control of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor. Endocr Rev, 1986. 7(4): pp. 351-78.
  3. Besedovsky, H.O., et al., Cytokines as modulators of the hypothalamus-pituitary-adre- nal axis. J Steroid Biochem Mol Biol, 1991. 40(4-6): pp. 613-8.
  4. Feldman, S., N. Conforti, and J. Weidenfeld, Limbic pathways and hypothalamic neu- rotransmitters mediating adrenocortical responses to neural stimuli. Neurosci Biobehav Rev, 1995. 19(2): pp. 235-40.
  5. Jankord, R. and J.P. Herman, Limbic regulation of hypothalamo-pituitary-adrenocor- tical function during acute and chronic stress. Ann N Y Acad Sci, 2008. 1148: pp. 64-73.
  6. Gray, T.S., M.E. Carney, and D.J. Magnuson, Direct projections from the central amygda- loid nucleus to the hypothalamic paraventricular nucleus: possible role in stress-induced adrenocorticotropin release. Neuroendocrinology, 1989. 50(4): pp. 433-46.
  7. Weidenfeld, J., et al., ACTH and corticosterone secretion following 2-deoxyglucose administration in intact and in hypothalamic deafferentated male rats. Brain Res, 1984. 305(1): pp. 109-13.
  8. Weidenfeld, J., et al., ACTH and corticosterone secretion following insulin in intact and in variously hypothalamic deafferented male rats. Exp Brain Res, 1982. 48(2): pp. 306-8.
  9. Sawchenko, P.E. and L.W. Swanson, The organization of forebrain afferents to the para- ventricular and supraoptic nuclei of the rat. J Comp Neurol, 1983. 218(2): pp. 121-44.
  10. Feldman, S., et al., Differential effect of amygdaloid lesions on CRF-41, ACTH and corti- costerone responses following neural stimuli. Brain Res, 1994. 658(1-2): pp. 21-6.
  11. Feldman, S. and N. Conforti, Amygdalectomy inhibits adrenocortical responses to somatosensory and olfactory stimulation. Neuroendocrinology, 1981. 32(6): pp. 330-4.
  12. Vale, W., et al., Chemical and biological characterization of corticotropin releasing fac- tor. Recent Prog Horm Res, 1983. 39: pp. 245-70.
  13. DeKeyser, F.G., R.R. Leker, and J. Weidenfeld, Activation of the adrenocortical axis by surgical stress: involvement of central norepinephrine and interleukin-1. Neuroimmunomodulation, 2000. 7(4): pp. 182-8.
  14. Holte, K. and H. Kehlet, Epidural anaesthesia and analgesia-effects on surgical stress responses and implications for postoperative nutrition. Clin Nutr, 2002. 21(3): pp. 199-206.
  15. Kroin, J.S., et al., Upregulation of spinal cyclooxygenase-2 in rats after surgical incision. Anesthesiology, 2004. 100(2): pp. 364-9.
  16. Shavit, Y., et al., Effects of surgical stress on brain prostaglandin E2 production and on the pituitary-adrenal axis: attenuation by preemptive analgesia and by central amygdala lesion. Brain Res, 2005. 1047(1): pp. 10-7.
  17. Dunn, A.J., The role of interleukin-1 and tumor necrosis factor alpha in the neuro- chemical and neuroendocrine responses to endotoxin. Brain Res Bull, 1992. 29(6): pp. 807-12.
  18. Taylor, B.K., et al., Pituitary-adrenocortical responses to persistent noxious stimuli in the awake rat: endogenous corticosterone does not reduce nociception in the formalin test. Endocrinology, 1998. 139(5): pp. 2407-13.
  19. Matsumura, K., et al., Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography. Brain Res, 1992. 581(2): pp. 292-8.
  20. Quan, N., M. Whiteside, and M. Herkenham, Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide. Brain Res, 1998. 802(1-2): pp. 189-97.
  21. Matsuoka, Y., et al., Impaired adrenocorticotropic hormone response to bacterial endo- toxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. Proc Natl Acad Sci U S A, 2003. 100(7): pp. 4132-7.
  22. Feldman, S., et al., The role of limbic structures in the modulation of ACTH responses following adrenalectomy. Ann N Y Acad Sci, 1995. 771: pp. 73-81.
  23. Weidenfeld, J. and S. Feldman, Effect of hypothalamic norepinephrine depletion on median eminence CRF-41 content and serum ACTH in control and adrenalectomized rats. Brain Res, 1991. 542(2): pp. 201-4.
  24. Ben-Hur, T., et al., Rescue of HSV-1 neurovirulence is associated with induction of brain interleukin-1 expression, prostaglandin synthesis and neuroendocrine responses. J Neurovirol, 1996. 2(4): pp. 279-88.
  25. Ben Hur, T., et al., Adrenocortical activation by herpes virus: involvement of IL-1 beta and central noradrenergic system. Neuroreport, 1996. 7(4): pp. 927-31.
  26. Xu, Y., T.A. Day, and K.M. Buller, The central amygdala modulates hypothalamic-pitu- itary-adrenal axis responses to systemic interleukin-1beta administration. Neuroscience, 1999. 94(1): pp. 175-83.
  27. Weidenfeld, J., et al., Role of the central amygdala in modulating the pituitary-adre- nocortical and clinical responses in experimental herpes simplex virus-1 encephalitis. Neuroendocrinology, 2005. 81(4): pp. 267-72.
  28. Jedema, H.P. and A.A. Grace, Corticotropin-releasing hormone directly activates nor- adrenergic neurons of the locus ceruleus recorded in vitro. J Neurosci, 2004. 24(43): pp. 9703-13.
  29. Peyron, C., et al., Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods. Neuroscience, 1998. 82(2): pp. 443-68.
  30. Van Bockstaele, E.J., et al., Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus. Physiol Behav, 2001. 73(3): pp. 273-83.
  31. Weidenfeld, J., et al., The amygdala regulates the pituitary-adrenocortical response and release of hypothalamic serotonin following electrical stimulation of the dorsal raphe nucleus in the rat. Neuroendocrinology, 2002. 76(2): pp. 63-9.
  32. Weidenfeld, J., O. Abramsky, and H. Ovadia, Evidence for the involvement of the central adrenergic system in interleukin 1-induced adrenocortical response. Neuropharmacology, 1989. 28(12): pp. 1411-4.
  33. Ben-Hur, T., et al., Acute effects of purified and UV-inactivated Herpes simplex virus type 1 on the hypothalamo-pituitary-adrenocortical axis. Neuroendocrinology, 2001. 74(3): pp. 160-6.
  34. Feldman, S. and J. Weidenfeld, Hypothalamic mechanisms mediating glutamate effects on the hypothalamo-pituitary-adrenocortical axis. J Neural Transm (Vienna), 1997. 104(6-7): pp. 633-42.
  35. Makara, G.B. and E. Stark, Effect of intraventricular glutamate on ACTH release. Neuro- endocrinology, 1975. 18(2): pp. 213-6.
  36. Daftary, S.S., et al., Noradrenergic excitation of magnocellular neurons in the rat hypo- thalamic paraventricular nucleus via intranuclear glutamatergic circuits. J Neurosci, 1998. 18(24): pp. 10619-28.
  37. Feldman, S. and J. Weidenfeld, Involvement of endogenous glutamate in the stimulatory effect of norepinephrine and serotonin on the hypothalamo-pituitary-adrenocortical axis. Neuroendocrinology, 2004. 79(1): pp. 43-53.
  38. Weidenfeld, J., et al., Adrenocortical axis responses to adrenergic and glutamate stimula- tion are regulated by the amygdala. Neuroreport, 2005. 16(11): pp. 1245-9.
  39. Roder, S. and J. Ciriello, Innervation of the amygdaloid complex by catecholaminergic cell groups of the ventrolateral medulla. J Comp Neurol, 1993. 332(1): pp. 105-22.
  40. Feldman, S. and J. Weidenfeld, Norepinephrine depletion in the amygdala inhibits CRF- 41, ACTH, and corticosterone responses following photic simulation. Brain Res Bull, 1996. 41(2): pp. 83-6.
  41. Pacak, K., et al., Effects of single or repeated immobilization on release of norepi- nephrine and its metabolites in the central nucleus of the amygdala in conscious rats. Neuroendocrinology, 1993. 57(4): pp. 626-33.
  42. Tanaka, T., et al., Noradrenaline release in the rat amygdala is increased by stress: stud- ies with intracerebral microdialysis. Brain Res, 1991. 544(1): pp. 174-6.
  43. Feldman, S. and J. Weidenfeld, Involvement of amygdalar alpha adrenoceptors in hypo- thalamo-pituitary-adrenocortical responses. Neuroreport, 1996. 7(18): pp. 3055-7.
  44. Feldman, S., et al., Role of serotonin in the amygdala in hypothalamo-pituitary-adreno- cortical responses. Neuroreport, 1998. 9(9): pp. 2007-9.
  45. Feldman, S., M.E. Newman, and J. Weidenfeld, Effects of adrenergic and serotonergic agonists in the amygdala on the hypothalamo-pituitary-adrenocortical axis. Brain Res Bull, 2000. 52(6): pp. 531-6.
  46. Feldman, S. and J. Weidenfeld, The excitatory effects of the amygdala on hypothalamo- pituitary-adrenocortical responses are mediated by hypothalamic norepinephrine, sero- tonin, and CRF-41. Brain Res Bull, 1998. 45(4): pp. 389-93.
  47. Feldman, S. and J. Weidenfeld, Neural mechanisms involved in the corticosteroid feed- back effects on the hypothalamo-pituitary-adrenocortical axis. Prog Neurobiol, 1995. 45(2): pp. 129-41.
  48. Clark, M., et al., Modulation of hippocampal glucocorticoid and mineralocorticoid receptor mRNA expression by amygdaloid kindling. Neuroendocrinology, 1994. 59(5): pp. 451-6.
  49. Weidenfeld, J., A. Itzik, and H. Ovadia, Electrical stimulation of the amygdala modifies the negative feedback effect of glucocorticoids on the adrenocortical responses to stress. Neuroimmunomodulation, 2015. 22(6): pp. 394-9.

Cited by

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Authors
Weidenfeld, J., & Ovadia, H.
Corresponding author
Ovadia, Haim
Venue
The Amygdala - Where Emotions Shape Perception, Learning and Memories
Publisher
InTech
Published
2017-07-05
DOI
10.5772/67828
OpenAlex
W2727073559
Cited by
14
References
0
Citations by year
2026: 1 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 1 · 2018: 1
FWCI
1.03
Type
book chapter
Language
en
Open access
Licence
Locations
  • InTech eBooks (publishedVersion, cc-by)
  • BiblioBoard Library Catalog (Open Research Library) (submittedVersion, cc-by)
  • Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech) (submittedVersion, cc-by)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
amygdala, hypothalamic-pituitary-adrenal axis, corticotropin-releasing factor, ACTH, corticosterone, norepinephrine, serotonin, stress response, paraventricular nucleus, raphe nuclei, glucocorticoid negative feedback

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