Autologous Peripheral Blood Stem Cell Transplantation Improves Portal Hemodynamics in Patients with Hepatitis B Virus-related Decompensated Cirrhosis
Open accessAbstract
BACKGROUND: Chronic hepatitis B virus (HBV) infection may eventually lead to decompensated liver cirrhosis, which is a terminal illness. OBJECTIVES: The aim of this study was to investigate the therapeutic efficacy of autologous peripheral blood stem cell (APBSC) transplantation to improve portal vein hemodynamics in patients with HBV-related decompensated cirrhosis. PATIENTS AND METHODS: This prospective study included 68 hospitalized patients who were diagnosed with HBV-related decompensated cirrhosis. These patients were divided into two groups: the transplantation group included 33 patients, while the control group included 35. Both groups received conventional medical treatment simultaneously, and APBSC transplantation was performed on the patients in the transplantation group. We evaluated the effects of APBSC transplantation on postoperative liver function using the following indices: total bilirubin, serum prothrombin and albumin, spleen size, and portal vein hemodynamics. Postoperatively, all of the patients were followed up at 24, 36, and 48 weeks. RESULTS: The transplantation group had no serious reactions. Compared with the control group, albumin and prothrombin activity in the transplantation group was significantly improved at 24, 36, and 48 weeks after the procedure, and spleen length and portal vein diameter were substantially reduced at 48 weeks. The velocity of peak portal vein blood flow and mean maximum portal vein blood flow were greatly increased in the APBSC transplantation group at 36 and 48 weeks, respectively; however, there was also decreased portal vein diameter, which reduced portal vein pressure in patients with HBV-related decompensated cirrhosis. CONCLUSIONS: APBSC transplantation greatly benefits HBV-linked decompensated cirrhosis patients and should be recommended in clinical practice.
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In a clinical trial in China, administration of G-CSF-mobilized CD34+ HSPCs in patients with HBV-related decompensated liver cirrhosis through the hepatic artery led to significant enhancements in serum ALB levels, prothrombin activity, MELD scores, and Child-Pugh scores.
“A clinical trial in China reported that the administration of G-CSF-mobilized CD34+ HSPCs in patients with HBV-related DLC through the hepatic artery led to significant enhancements in serum ALB levels, prothrombin activity (PTA), MELD scores, and Child–Pugh scores [60].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [60]
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Chen, B., Pang, L., Cao, H., Wu, D., Wang, Y., Tao, Y., Wang, M., & Chen, E. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001455 · Cited by 14 · see citing works
Self-citationPan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2 · see citing works
“A clinical trial in China reported that the administration of G-CSF-mobilized CD34 + HSPCs in patients with HBV-related DLC through the hepatic artery led to significant enhancements in serum ALB levels, prothrombin activity (PTA), MELD scores, and Child–Pugh scores [60].”
- Authors
- Deng, Q., Cai, T., Zhang, S., Hu, A., Zhang, X., Wang, Y., & Huang, J.
- Affiliations
- Ningbo No. 2 Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Corresponding author
- Huang, Jianrong
- Venue
- Hepatitis Monthly
- Publisher
- Brieflands
- Published
- 2015-12-20
- Volume
- 15
- Issue
- 12
- Pages
- e32498-e32498
- ISSN
- 1735-143X (ISSN-L)
- 1735-3408
- PMC
- PMC4774339
- OpenAlex
- W2204126252
- Cited by
- 11
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Hepatitis Monthly (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- autologous peripheral blood stem cell transplantation, hepatitis B virus, decompensated cirrhosis, portal hemodynamics, portal pressure, portal blood flow, spleen size, liver function, albumin, prothrombin activity
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