Effects of Garlic Pill on Blood Glucose Level in Borderline Gestational Diabetes Mellitus: A Randomized Controlled Trial
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Background: Women with borderline gestational diabetes mellitus (BGDM) have a higher risk of complications in comparison with normal women. Objectives: The aim of this study was to determine the effects of garlic pill on fasting blood sugar (FBS) and relapse of prediabetes symptoms (primary outcomes), as well as blood pressure, neonatal anthropometric indices, and mode of delivery (secondary outcomes) in prediabetic pregnant women. Methods: This triple-blind, randomized clinical trial was conducted on 49 women with prediabetes at 24 to 28 weeks of gestation in Tabriz, Iran, during 2015 - 16. The participants were assigned to the intervention (n, 26) and control (n, 23) groups using block randomization. The intervention group received a 400-mg garlic pill per day, while the control group received a placebo pill per day for eight weeks. Four and eight weeks following the intervention, FBS and blood pressure were measured. The newborns’ anthropometric indices and mode of delivery were also recorded after delivery. Results: The mean FBS level in the garlic group decreased from 106.6 (11.1) mg/dL before the intervention to 83.6 (6.3) mg/dL at four weeks after the intervention and 79.4 (6.1) mg/dL at eight weeks after the intervention (adjusted mean difference, -3.7). The garlic pill also led to a significant decrease in prediabetes symptoms at four weeks after the intervention (P < 0.001) and diastolic blood pressure at four and eight weeks after the intervention (P = 0.041), compared to the control group. No significant difference was observed between the groups in terms of systolic blood pressure at four and eight weeks after the intervention, anthropometric indices, or mode of delivery. Conclusions: The results revealed that garlic pill could reduce FBS level, prediabetes symptoms, and diastolic blood pressure. However, further research with a larger sample size is required for more accurate results.
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Allyl propyl disulfide, allicin, cysteine sulfoxide, and S-allyl cysteine sulfoxide decreased blood glucose level by preventing insulin activation caused by liver, enhancing secretion of insulin from pancreatic beta cells, isolation of insulin from bonded forms, and increasing cell sensitivity to insulin.
“allyl propyl disulfide, allicin, cysteine sulfoxide, and S-allyl cysteine sulfoxide decreased the blood glucose level by preventing the insulin activation caused by liver, enhancing the secretion of insulin from pancreatic beta cells, isolation of insulin from the bonded forms, and increasing the cell sensitivity to insulin [114].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [114]
Garlic pills administration at 900 mg/day in patients with type II diabetes and hyperlipidemia decrease cholesterol, serum lipids, and fasting blood sugar.
“Another clinical study examined the antidiabetic effect of garlic pills administration at 900 mg/day in patients with type II diabetes and hyperlipidemia and they reported that garlic pills decrease the cholesterol, serum lipids, and fasting blood sugar [114].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [114]
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References 31 · Cited by 37
- Authors
- Faroughi, F., Mohammad-Alizadeh Charandabi, S., Javadzadeh, Y., & Mirghafourvand, M.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- ORCID
- Javadzadeh, Yousef
- Venue
- Iranian Red Crescent Medical Journal
- Publisher
- DoNotEdit
- Published
- 2018-05-05
- Volume
- 20
- Issue
- 7
- ISSN
- 2074-1804 (ISSN-L)
- 2074-1812
- OpenAlex
- W2802427323
- Cited by
- 37
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 9 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Iranian Red Crescent Medical Journal (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- garlic, fasting blood glucose, diastolic blood pressure, mode of delivery
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