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Cited by 78

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Prognostic Significance of Histomorphologic Parameters in Diffuse Malignant Peritoneal Mesothelioma

Cerruto, Carlos A., Brun, Erwin A., Chang, David, Sugarbaker, Paul H.·2006·Archives of Pathology & Laboratory Medicine
DOI 10.5858/2006-130-1654-psohpi
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Abstract

Context. —Diffuse malignant peritoneal mesothelioma is currently regarded as a rare and lethal primary tumor arising from the peritoneal membrane. In the past, treatment plans with variable combinations of surgery and systemic chemotherapy were associated with a median survival of approximately 1 year. Standardized treatments using cytoreductive surgery and perioperative intraperitoneal chemotherapy have extended this survival. Objective. —To critically analyze the prognostic significance of histomorphologic parameters as a determinant of survival. Design. —Sixty-two consecutive patients with diffuse malignant peritoneal mesothelioma in whom data were prospectively accumulated were retrospectively analyzed by 14 different histomorphologic parameters. The influences of these pathologic characteristics on survival were critically statistically evaluated. Results. —In a univariate analysis, histologic type, nuclear/nucleolar size, stroma, depth of invasion into the bowel, atypical mitoses, mitotic index, necrosis, lymph node involvement, and chromatin patterns were found to be significant. In the multivariate analysis, histologic type and nuclear/nucleolar size remained as determinant histomorphologic characteristics. Use of biphasic/sarcomatoid histologic type as a poor prognostic characteristic was limited in that only 8% of patients showed this histology. Conclusions. —Histomorphologic parameters carry prognostic significance in predicting the survival of patients with diffuse malignant peritoneal mesothelioma when treated in a standardized fashion using cytoreductive surgery and perioperative intraperitoneal chemotherapy. Nuclear/nucleolar size was found to be a reliable histomorphologic assessment available to assess prognosis in these patients.

Overview

Integrity signals

Registry

Crossref · 10.5858/2006-130-1654-psohpi

Cites

31 of 31 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. Greene, F. L., D. L.Page, and I. D.Fleming. et al. AJCC Cancer Staging Handbook From the AJCC Cancer Staging Manual. 6th ed.New York, NY: Springer; 2002.
  2. Sugarbaker, P. H., L.Welch, F.Mohamed, and O.Glehen. A review of peritoneal mesothelioma at the Washington Cancer Institute.Surg Oncol Clin North Am2003. 12:605–621.
  3. van Ruth, S., M. W. G. A.Bronkhorst, F.van Coevorden, and F. A. N.Zoetmulder. Peritoneal benign cystic mesothelioma: a case report and review of literature.Eur J Surg Oncol2002. 28:192–195.

Cited by

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Metadata

Authors
Cerruto, C. A., Brun, E. A., Chang, D., & Sugarbaker, P. H.
Affiliations
From the Department of Pathology, Washington Hospital Center, Washington, DC (Drs Cerruto and Brun); Westat, Rockville, Md (Dr Chang); and the Washington Cancer Institute, Washington, DC (Dr Sugarbaker)
Venue
Archives of Pathology & Laboratory Medicine
Publisher
Archives of Pathology and Laboratory Medicine
Published
2006-11
Volume
130
Issue
11
Pages
1654-1661
ISSN
  • 1543-2165
  • 0003-9985
DOI
10.5858/2006-130-1654-psohpi
Cited by
78
References
31

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