Organofluorine compounds: chemistry and applications

Abstract

Recently, fluorine has become a key element in the remarkable progress of materials and biologically active agents.Since fluorine has quite unique reactivities and properties, fluorine chemistry is recognized as being totally different from the chemistry of the other halogens.Accordingly, many books and reviews have been published.Most of them, however, were written by experts in specialized fields.Although many excellent monographs on organofluorine chemistry exist, this new textbook was undertaken with the aim of overviewing organofluorine chemistry on the basis of organic synthesis.Accordingly, the present work will focus on the organic chemistry of organofluorine compounds, starting with general discussions on the unique properties of the fluorine atom and carbon-fluorine bonds, natural resources, and the salient features of organofluorine compounds in addition to their toxicity.This will be followed by chapters on reagents and methods for the introduction of fluorine into organic compounds, organofluorine building blocks, reactions of C-F bonds, biologically active organofluorine compounds, fluorine-containing materials, fluorous media, and some synthetic reagents containing fluorine.The book focuses as much as possible on information that will be useful for synthetic chemists who have experienced or inexperienced organofluorine chemistry.