The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Human Bone Marrow-Derived Mesenchymal Stem Cells Display Enhanced Clonogenicity but Impaired Differentiation With Hypoxic Preconditioning
Open accessAbstract
Stem cells are promising candidate cells for regenerative applications because they possess high proliferative capacity and the potential to differentiate into other cell types. Mesenchymal stem cells (MSCs) are easily sourced but do not retain their proliferative and multilineage differentiative capabilities after prolonged ex vivo propagation. We investigated the use of hypoxia as a preconditioning agent and in differentiating cultures to enhance MSC function. Culture in 5% ambient O2 consistently enhanced clonogenic potential of primary MSCs from all donors tested. We determined that enhanced clonogenicity was attributable to increased proliferation, increased vascular endothelial growth factor secretion, and increased matrix turnover. Hypoxia did not impact the incidence of cell death. Application of hypoxia to osteogenic cultures resulted in enhanced total mineral deposition, although this effect was detected only in MSCs preconditioned in normoxic conditions. Osteogenesis-associated genes were upregulated in hypoxia, and alkaline phosphatase activity was enhanced. Adipogenic differentiation was inhibited by exposure to hypoxia during differentiation. Chondrogenesis in three-dimensional pellet cultures was inhibited by preconditioning with hypoxia. However, in cultures expanded under normoxia, hypoxia applied during subsequent pellet culture enhanced chondrogenesis. Whereas hypoxic preconditioning appears to be an excellent way to expand a highly clonogenic progenitor pool, our findings suggest that it may blunt the differentiation potential of MSCs, compromising their utility for regenerative tissue engineering. Exposure to hypoxia during differentiation (post-normoxic expansion), however, appears to result in a greater quantity of functional osteoblasts and chondrocytes and ultimately a larger quantity of high-quality differentiated tissue.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Thus, the question whether hypoxia preconditioning should become the standard of care for clinical application of MSCs remains to be answered [37, 38].”
From Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells (2018) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Yuan, G., Peng, Y., Reddy, V. D., Makarenko, V. V., Nanduri, J., Khan, S. A., Garcia, J. A., Kumar, G. K., Semenza, G. L., & Prabhakar, N. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305961110 · Cited by 82
RetractedBaksh, D., Yao, R., & Tuan, R. S. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0709 · Cited by 1,058
Self-citationNuclear PKM2 regulates β-catenin transactivation upon EGFR activation
Yang, W., Xia, Y., Ji, H., Zheng, Y., Liang, J., Huang, W., Gao, X., Aldape, K., & Lu, Z. (2011) · Nature · doi:10.1038/nature10598 · Cited by 1,051
Munemitsu, S. M., Albert, I., Souza, B., Rubinfeld, B., & Polakis, P. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.3046 · Cited by 1,021
Kolf, C. M., Cho, E., & Tuan, R. S. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2116 · Cited by 951
Self-citationAdult mesenchymal stem cells and cell-based tissue engineering.
Tuan, R. S., Boland, G. M., & Tuli, R. (2003) · Arthritis Research · doi:10.1186/ar614 · Cited by 780
Self-citationZhou, Z., Apte, S. S., Soininen, R., Cao, R., Baaklini, G. Y., Rauser, R. W., Wang, J., Cao, Y., & Tryggvason, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.060037197 · Cited by 666
Boland, G. M., Perkins, G., Hall, D. J., & Tuan, R. S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20284 · Cited by 578
Self-citationHypoxia enhances proliferation and tissue formation of human mesenchymal stem cells
Grayson, W. L., Zhao, F., Bunnell, B., & Ma, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.054 · Cited by 521
Fehrer, C., Brunauer, R., Laschober, G. T., Unterluggauer, H., Reitinger, S., Kloss, F. R., Gülly, C., Gassner, R. J., & Lepperdinger, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00336.x · Cited by 498
Research works printed but not linked: 2
- Caplan, 1983, The development of embryonic bone and cartilage in tissue culture, Clin Orthop Relat Res, 174, 243, 10.1097/00003086-198304000-00036 · DOI
- Taboas, 2004, Mechanobiologic Regulation of Skeletal Progenitor Cell Differentiation [Ph.D. thesis]
Cited by
Sorted by citations
Preconditioning influences mesenchymal stem cell properties in vitro and in vivo
Hu, C., & Li, L. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13492 · Cited by 452
Li, Q., Gao, Z., Chen, Y., & Guan, M. (2017) · Protein & Cell · doi:10.1007/s13238-017-0385-7 · Cited by 356
Concise Review: Wharton's Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells
Davies, J. E., Walker, J. T., & Keating, A. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0492 · Cited by 219
Strategies to Optimize Adult Stem Cell Therapy for Tissue Regeneration
Liu, S., Zhou, J., Zhang, X., Liu, Y., Chen, J., Hu, B., Song, J., & Zhang, Y. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060982 · Cited by 177
Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy
Mohammadalipour, A., Dumbali, S. P., & Wenzel, P. L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603292 · Cited by 182
Adverse events, side effects and complications in mesenchymal stromal cell-based therapies
Baranovskii, D., Klabukov, I., Arguchinskaya, N. V., Yakimova, A. O., Kisel, A. A., Yatsenko, E. M., Иванов, С. А., Шегай, П. В., & Каприн, А. Д. (2022) · Stem Cell Investigation · doi:10.21037/sci-2022-025 · Cited by 154
Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration
Toh, W. S., Foldager, C. B., Pei, M., & Hui, J. H. P. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-014-9526-z · Cited by 146
Chen, X., Gu, S., Chen, B., Shen, W., Yin, Z., Xu, G., Hu, J., Zhu, T., Li, G., Wan, C., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.071 · Cited by 142
Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells
Antebi, B., Rodriguez, L. A., Walker, K. P., Asher, A. M., Kamucheka, R. M., Alvarado, L., Mohammadipoor, A., & Cancio, L. C. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1007-x · Cited by 137
Hypoxia-Conditioned Mesenchymal Stem Cells in Tissue Regeneration Application
Yang, Y., Lee, E. H., & Yang, Z. (2021) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2021.0145 · Cited by 153
Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells
García‐Sánchez, D., Fernández, D., Rodríguez-Rey, J. C., & Pérez-Campo, F. M. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i10.748 · Cited by 107
Discrepancies on the Role of Oxygen Gradient and Culture Condition on Mesenchymal Stem Cell Fate
Samal, J. R. K., Rangasami, V. K., Samanta, S., Varghese, O. P., & Oommen, O. P. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002058 · Cited by 99
3D Bioprinting for Vascularized Tissue-Engineered Bone Fabrication
Xing, F., Xiang, Z., Rommens, P. M., & Ritz, U. (2020) · Materials · doi:10.3390/ma13102278 · Cited by 99
Pulido-Escribano, V., Torrecillas-Baena, B., Camacho-Cardeñosa, M., Dorado, G., Gálvez-Moreno, M. Á., & Casado‐Díaz, A. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i7.453 · Cited by 102
Fu, S.-P., Chen, S., Pang, Q.-M., Zhang, M., Wu, X.-C., Wan, X., Wan, W.-H., Ao, J., & Zhang, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1014013 · Cited by 92
Bornes, T. D., Jomha, N. M., Mulet‐Sierra, A., & Adesida, A. B. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0075-4 · Cited by 86
Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells
de Soure, A. M., Fernandes‐Platzgummer, A., da Silva, C. L., & Cabral, J. M. S. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.08.007 · Cited by 87
Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential
Pei, M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.049 · Cited by 83
Kuss, M. A., Harms, R., Wu, S., Wang, Y., Untrauer, J. B., Carlson, M. A., & Duan, B. (2017) · RSC Advances · doi:10.1039/c7ra04372d · Cited by 81
Bone Defect Reconstruction Via Endochondral Ossification: A Developmental Engineering Strategy
Fu, R., Liu, C., Li, J., Yan, Y., Xie, Y., Li, Q., & Huang, R. (2020) · Journal of Tissue Engineering · doi:10.1177/20417314211004211 · Cited by 81
Pattappa, G., Johnstone, B., Zellner, J., Docheva, D., & Angele, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030484 · Cited by 82
Kang, I., Lee, B., Choi, S. W., Lee, J. Y., Kim, J.-J., Kim, B., Kim, D., Lee, S. E., Shin, N., Seo, Y., et al. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-017-0014-9 · Cited by 74
Hypoxia Modulates the Differentiation Potential of Stem Cells of the Apical Papilla
Vanacker, J., Viswanath, A., Berdt, P. D., Everard, A., Cani, P. D., Bouzin, C., Féron, O., Diogenes, A. R., Leprince, J. G., & Rieux, A. D. (2014) · Journal of Endodontics · doi:10.1016/j.joen.2014.04.008 · Cited by 70
Guillot-Ferriols, M. T., Lanceros-Méndez, S., Ribelles, J. L. G., & Ferrer, G. G. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212918 · Cited by 66
Zhang, L., Yang, C., Li, J., Zhu, Y., & Zhang, X. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.07.004 · Cited by 66
Zhang, J., Feng, Z., Wei, J., Yu, Y., Luo, J., Zhou, J., Li, Y., Zheng, X., Tang, W. D., Liu, L., et al. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.24158 · Cited by 60
Nowak-Stępniowska, A., Osuchowska, P. N., Fiedorowicz, H., & Trafny, E. A. (2022) · Stem Cells International · doi:10.1155/2022/8775591 · Cited by 59
Elabd, C., Ichim, T. E., Miller, K., Anneling, A., Grinstein, V., Vargas, V., & Silva, F. J. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1601-9 · Cited by 57
Critical Review on the Physical and Mechanical Factors Involved in Tissue Engineering of Cartilage
Gaut, C., & Sugaya, K. (2015) · Regenerative Medicine · doi:10.2217/rme.15.31 · Cited by 54
Legendre, F., Ollitrault, D., Gómez-Leduc, T., Bouyoucef, M., Hervieu, M., Gruchy, N., Mallein‐Gérin, F., Leclercq, S., Demoor, M., & Galéra, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-03579-y · Cited by 52
Peck, S. H., Bendigo, J. R., Tobias, J. W., Dodge, G. R., Malhotra, N. R., Mauck, R. L., & Smith, L. J. (2019) · Cartilage · doi:10.1177/1947603519841675 · Cited by 50
Heat Shock Alters Mesenchymal Stem Cell Identity and Induces Premature Senescence
Shimoni, C., Goldstein, M., Ribarski-Chorev, I., Schauten, I., Nir, D., Strauss, C., & Schlesinger, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.565970 · Cited by 47
Marsano, A., da Cunha, C. M. M., Ghanaati, S., Güven, S., Centola, M., Tsaryk, R., Barbeck, M., Stüdle, C., Barbero, A., Helmrich, U., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0321 · Cited by 50
Stem Cells for Temporomandibular Joint Repair and Regeneration
Zhang, S., Yap, A. U., & Toh, W. S. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9604-x · Cited by 47
Ciapetti, G., Granchi, D., Fotia, C., Savarino, L., Dallari, D., Piccolo, N. D., Donati, D. M., & Baldini, N. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2016.06.005 · Cited by 43
Revisiting MSC expansion from critical quality attributes to critical culture process parameters
Martin, C., Olmos, É., Collignon, M.-L., de Isla, N., Blanchard, F., Chevalot, I., Marc, A., & Guédon, E. (2016) · Process Biochemistry · doi:10.1016/j.procbio.2016.04.017 · Cited by 41
Zhao, H., Yeersheng, R., Xia, Y., Kang, P., & Wang, W. (2021) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2021.03.005 · Cited by 39
Hoffmann, A., Floerkemeier, T., Melzer, C., & Hass, R. (2016) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2153 · Cited by 39
Stiers, P., van Gastel, N., & Carmeliet, G. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.024 · Cited by 37
Effects of Hypoxia on Differentiation of Mesenchymal Stem Cells
Chen, W., Zhuo, Y., Duan, D., & Lü, M. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666190823144928 · Cited by 35
Oxygen-Generating Biomaterials for Translational Bone Regenerative Engineering
Hosseini, F. S., Abedini, A. A., Chen, F., Whitfield, T., Ude, C. C., & Laurencin, C. T. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c20715 · Cited by 35
Kheirandish, M., Gavgani, S. P., & Samiee, S. (2017) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2017.03.015 · Cited by 34
Articular Cartilage Repair with Mesenchymal Stem Cells After Chondrogenic Priming: A Pilot Study
Bornes, T. D., Adesida, A. B., & Jomha, N. M. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0235 · Cited by 34
Chen, Y., Zhao, Q., Yang, X., Yu, X., Yu, D., & Zhao, W. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-00981-5 · Cited by 32
Recent Advancements of Bioinks for 3D Bioprinting of Human Tissues and Organs
He, W., Deng, J., Ma, B., Tao, K., Zhang, Z., Ramakrishna, S., Yuan, W., & Ye, T. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00806 · Cited by 32
Sha, Y., Lv, Y., Xu, Z., Yang, L., Hao, X., & Afandi, R. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.09.017 · Cited by 29
Metabolomics Analysis of Mesenchymal Stem Cells.
Goodarzi, P., Alavi-Moghadam, S., Payab, M., Larijani, B. A., Rahim, F., Gilany, K., Bana, N., Tayanloo-Beik, A., Heravani, N. F., Hadavandkhani, M., et al. (2019) · PubMed Central · doi:10.22088/ijmcm.bums.8.2.30 · Cited by 27
Yu, Y., Yin, Y., Wu, R., He, X., Zhang, X., & Chen, F. (2016) · Cell Proliferation · doi:10.1111/cpr.12309 · Cited by 26
Khatlani, T., Algudiri, D., Alenzi, R., Subayyil, A. M. A., Abomaray, F., Bahattab, E., Alaskar, A. S., Kalionis, B., El-Muzaini, M. F., & Abumaree, M. (2018) · Stem Cells International · doi:10.1155/2018/6480793 · Cited by 25
He, D., Lu, Y., Hu, H., Zhang, J., Qin, B., Wang, Y., Xing, S., Xi, Q., & Wang, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160716313 · Cited by 23
Bellinger, D. L., Wood, C. A., Wergedal, J. E., & Lorton, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628065 · Cited by 23
Hypoxia Promotes Osteogenesis of Human Placental-Derived Mesenchymal Stem Cells
Gu, Q., Gu, Y., Shi, Q., & Yang, H. (2016) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.239.287 · Cited by 23
Huang, Y.-C., Parolini, O., Deng, L., & Yu, B.-S. (2016) · Stem Cells · doi:10.1002/stem.2389 · Cited by 22
Ji, K., Ding, L., Chen, X., Dai, Y., Sun, F., Wu, G., & Wei, L. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15666200324165655 · Cited by 19
Camacho-Cardeñosa, M., Quesada‐Gómez, J. M., Camacho-Cardeñosa, A., Leal, A., Dorado, G., Torrecillas-Baena, B., & Casado‐Díaz, A. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i12.1667 · Cited by 17
Peng, X., Liang, B., Wang, H., Hou, J., & Yuan, Q. (2022) · Cell and Tissue Research · doi:10.1007/s00441-021-03562-0 · Cited by 16
New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury
Ezquer, F. E., Huang, Y.-L., & Ezquer, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052669 · Cited by 17
Menon, A., Creo, P., Piccoli, M., Bergante, S., Conforti, E., Banfi, G., Randelli, P. S., & Anastasia, L. (2018) · Stem Cells International · doi:10.1155/2018/9468085 · Cited by 15
Fan, L., Liu, R., Li, J., Shi, Z., Dang, X., & Wang, K. (2015) · Stem Cells International · doi:10.1155/2015/950312 · Cited by 16
Autophagy: a promising therapeutic target for improving mesenchymal stem cell biological functions
Deng, J., Zhong, L., Zhou, Z., Gu, C., Xiaoya, H., Shen, L., Cao, S., Ren, Z., Zuo, Z., Deng, J., et al. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03978-2 · Cited by 15
Stem Cells in Skeletal Tissue Engineering: Technologies and Models
Langhans, M. T., Yu, S., & Tuan, R. S. (2015) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x10666151001115248 · Cited by 15
Self-citationStrecanska, M., Sekelova, T., Csöbönyeiová, M., Danišovič, Ľ., & Čeháková, M. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122647 · Cited by 14
Up-to-date progress in bioprinting of bone tissue
Wu, Y. B., Li, M., Su, H., Chen, H., & Zhu, Y. (2022) · International Journal of Bioprinting · doi:10.18063/ijb.v9i1.628 · Cited by 14
Zhang, M., Shi, X.-L., Wu, J., Wang, Y., Lin, J. J., Zhao, Y. N., Li, H., Ren, M., Hu, R., Liu, F., et al. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.104525 · Cited by 14
Balgi, S., Winter, C., Corral, A., Mustafa, S. B., Hornsby, P. J., & Moreira, A. G. (2018) · Cells Tissues Organs · doi:10.1159/000489256 · Cited by 12
Yang, Y., Hong, L., & Wang, B. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.049 · Cited by 12
Ranmuthu, C. K. I., Ranmuthu, C. D. S., Wijewardena, C. K., Seah, M. K. T., & Khan, W. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315210 · Cited by 12
Zhang, S., Chan, R., Ng, E. H. Y., & Yeung, W. S. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094613 · Cited by 11
Bianconi, S., Oliveira, K. M. C., Klein, K., Wolf, J., Schaible, A., Schröder, K., Barker, J. H., Marzi, İ., Leppik, L. P., & Henrich, D. M. (2023) · Cells · doi:10.3390/cells12172151 · Cited by 11
Beneficial Effects of Hypoxic Preconditioning on Human Umbilical Cord Mesenchymal Stem Cells.
Zhang, L., Yang, J., Tian, Y., Guo, H., & Zhang, Y. (2015) · PubMed · doi:10.4077/cjp.2015.bae369 · Cited by 11
Carmona-Luque, M. D., Paco-Meza, L.-M., Ortega, R., Cañadillas, S., Caballero‐Villarraso, J., Blanco, A., & Herrera, C. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153756 · Cited by 10
Yang, H. Y., Chen, J., & Li, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1243220 · Cited by 10
Skibiński, S., Czechowska, J. P., Cichoń, E., Seta, M., Gondek, A., Cudnoch‐Jędrzejewska, A., Slosarczyk, A., Guzik, M. W., & Zima, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911587 · Cited by 10
Gao, S., Xiang, C., Qin, K., & Sun, C. (2018) · Stem Cells International · doi:10.1155/2018/9283432 · Cited by 11
Nugraha, A. P., Narmada, I. B., Winoto, E. R., Ardani, I. G. A. W., Triwardhani, A., Alida, A., Pramusita, A., Nur, R. M., Indrastie, N., Nam, H. Y., et al. (2023) · European Journal of Dentistry · doi:10.1055/s-0043-1772699 · Cited by 9
Nondestructive Techniques to Evaluate the Characteristics and Development of Engineered Cartilage
Mansour, J. M., Lee, Z., & Welter, J. F. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-015-1535-9 · Cited by 8
Taghiyar, L., Hosseini, S., Hesaraki, M., Sayahpour, F. A., Aghdami, N., & Eslaminejad, M. B. (2018) · PubMed Central · doi:10.22074/cellj.2018.4710 · Cited by 8
tRNA‐derived small RNA changes in bone marrow stem cells under hypoxia and osteogenic conduction
Zhang, C., Ye, W., Zhao, M., Xia, D., & Fan, Z. (2023) · Journal of Oral Rehabilitation · doi:10.1111/joor.13566 · Cited by 7
Evolution of Stem Cell Products in Medicine: Future of Off-the-Shelf Products
Pham, P. V., Nguyen, H. T., & Vu, N. B. (2018) · Stem cells in clinical applications · doi:10.1007/978-3-319-99328-7_6 · Cited by 7
Ajeeb, B., & Detamore, M. S. (2023) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2023.100369 · Cited by 7
Sun, Y., Chen, G., & Lv, Y. (2019) · Acta Mechanica Sinica · doi:10.1007/s10409-019-00845-2 · Cited by 7
Tang, X., Zheng, N., Lin, Q., You, Y., Gong, Z., Zhuang, Y., Wu, J., Wang, Y., Huang, H., Ke, J., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01922 · Cited by 6
Lin, Q., & Lin, X. M. (2023) · Biotechnology Journal · doi:10.1002/biot.202300070 · Cited by 5
Camacho-Cardeñosa, M., Pulido-Escribano, V., Torrecillas-Baena, B., Quesada‐Gómez, J. M., Herrera-Martínez, A. D., Sola‐Guirado, R. R., Dorado, G., Gálvez-Moreno, M. Á., & Casado‐Díaz, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195805 · Cited by 5
Andreeva, E. R., Zhidkova, O., Константиновна, М. Д., Gornostaeva, A. N., Lobanova, M. V., & Buravkova, L. B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136301 · Cited by 4
Ramos‐Rodriguez, D. H., Fok, S. W., Dorais, C. J., Filler, A. C., Caserta, M., & Leach, J. K. (2024) · Tissue Engineering Part A · doi:10.1089/ten.tea.2024.0267 · Cited by 4
Unlocking MSC Potential: Metabolic Reprogramming via Synthetic Biology Approaches
Trufanova, N. A., Trufanov, O., & Petrenko, O. (2025) · SynBio · doi:10.3390/synbio3030013 · Cited by 4
Lee, J., Kim, J., Bong, K. W., & Song, S. (2025) · Biomaterials Science · doi:10.1039/d5bm00480b · Cited by 4
Recent Progress in Stem Cell Chondrogenesis
Toh, W. S. (2014) · Progress in Stem Cell · doi:10.7603/s40855-014-0003-5 · Cited by 3
Li, Z.-B., Yang, H., Li, K., Yin, Y., Feng, S.-S., Ge, S., & Yu, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.797055 · Cited by 4
Stem Cells for Articular Cartilage Repair and Regeneration
Parate, D., Zhang, S., Hui, J. H. P., & Toh, W. S. (2016) · Stem cells in clinical applications · doi:10.1007/978-3-319-40144-7_7 · Cited by 3
Martín‐Peña, A., Porter, R. M., Plumton, G., McCarrel, T. M., Morton, A., Guijarro, M. V., Ghivizzani, S., Sharma, B., & Palmer, G. (2018) · European Cells and Materials · doi:10.22203/ecm.v036a12 · Cited by 3
Wu, Y. B., Fuh, J. Y. H., & Ozbolat, I. T. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824291-9.00003-8 · Cited by 2
Stem Cell-Based Therapies for Osteoarthritis: From Pre-Clinical to Clinical Applications
Toumi, H., Lespessailles, É., & Mazor, M. (2017) · InTech eBooks · doi:10.5772/intechopen.68176 · Cited by 2
Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and Regeneration
Ye, Y., Zhao, X., Xu, Y., & Yu, J. (2021) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2021.799716 · Cited by 5
Karimi, M., Zandsalimi, K., Jafary, H., Akbari, N., & Heidari, B. (2025) · Research Square · doi:10.21203/rs.3.rs-7136519/v1 · Cited by 2
Cellular Technologies in Traumatology: From Cells to Tissue Engineering
Дремина, Н. Н., Сергеевна, Т. И., & Александровна, Ш. И. (2021) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2021-6.2.19 · Cited by 1
Lin, J.-W., Fan, C., Kuo, T.-T., & Yeh, C. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114585 · Cited by 1
Effects of hypoxia on the biological characteristics of urine-derived stem cells
Xiao, Y., Guo, Z., Shao, W., Hq, X., & Huang, Y. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1851623 · Cited by 1
The SCD – Stem Cell Differentiation ESA Project: Preparatory Work for the Spaceflight Mission
Versari, S., Barenghi, L., van Loon, J. J. W. A., & Bradamante, S. (2015) · Microgravity Science and Technology · doi:10.1007/s12217-015-9466-5 · Cited by 1
Metadata
- Authors
- Boyette, L. B., Creasey, O. A., Guzik, L., Lozito, T., & Tuan, R. S.
- Affiliations
- National Institutes of Health (US)
- University of Pittsburgh (US)
- Corresponding author
- Tuan, Rocky S.
- Venue
- Stem Cells Translational Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01-16
- Volume
- 3
- Issue
- 2
- Pages
- 241-254
- ISSN
- 2157-6564 (ISSN-L)
- 2157-6580
- PMC
- PMC3925051
- OpenAlex
- W1985367412
- Cited by
- 121
- References
- 95
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 5 · 2023: 12 · 2022: 14 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 13 · 2017: 10 · 2016: 15 · 2015: 9 · 2014: 4
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Stem Cells Translational Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (Z01AR41131)
- Commonwealth of Pennsylvania Department of Health (SAP4100050913)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- mesenchymal stem cells, bone marrow-derived stem cells, hypoxic preconditioning, clonogenicity, osteogenic differentiation, adipogenesis, chondrogenesis, vascular endothelial growth factor, alkaline phosphatase, extracellular matrix turnover, stem cell expansion, regenerative medicine
- MeSH terms
- Hypoxia, Cell Differentiation, Cells, Cultured, Clone Cells, Fibroblasts, Humans, Osteocytes, Oxygen, Immunophenotyping, Cytokines, Cell Death, Adipocytes, Ischemic Preconditioning, Chondrocytes, Matrix Metalloproteinases, Cell Proliferation, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
