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NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023: Featured Updates to the NCCN Guidelines

Zelenetz, Andrew D., Gordon, Leo I., Abramson, Jeremy S., Advani, Ranjana H., Andreadis, Babis, Bartlett, Nancy L., Budde, L. Elizabeth, Caimi, Paolo F., Chang, Julie E., Christian, Beth, DeVos, Sven, Dholaria, Bhagirathbhai, Fayad, Luis E., Habermann, Thomas M., Hamid, Muhammad Saad, Hernandez-Ilizaliturri, Francisco, Hu, Boyu, Kaminski, Mark S., Karimi, Yasmin, Kelsey, Christopher R., King, Rebecca, Krivacic, Susan, LaCasce, Ann S., Lim, Megan, Messmer, Marcus, Narkhede, Mayur, Rabinovitch, Rachel, Ramakrishnan, Praveen, Reid, Erin, Roberts, Kenneth B., Saeed, Hayder, Smith, Stephen D., Svoboda, Jakub, Swinnen, Lode J., Tuscano, Joseph, Vose, Julie M., Dwyer, Mary A., Sundar, Hema·2023·Journal of the National Comprehensive Cancer Network

Abstract

Novel targeted therapies (small molecule inhibitors, antibody–drug conjugates, and CD19-directed therapies) have changed the treatment landscape of relapsed/refractory B-cell lymphomas. Bruton’s tyrosine kinase (BTK) inhibitors continue to evolve in the management of mantle cell lymphoma (MCL), in both the relapsed/refractory and the frontline setting. Anti-CD19 CAR T-cell therapies are now effective and approved treatment options for relapsed/refractory follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and MCL. Bispecific T-cell engagers represent a novel immunotherapeutic approach for relapsed FL and DLBCL after multiple lines of therapies, including prior CAR T-cell therapy. These NCCN Guideline Insights highlight the significant updates to the NCCN Guidelines for B-Cell Lymphomas for the treatment of FL, DLBCL, and MCL.

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Metadata

Authors
Zelenetz, A. D., Gordon, L. I., Abramson, J. S., Advani, R. H., Andreadis, B., Bartlett, N. L., Budde, L. E., Caimi, P. F., Chang, J. E., Christian, B., DeVos, S., Dholaria, B., Fayad, L. E., Habermann, T. M., Hamid, M. S., Hernandez-Ilizaliturri, F., Hu, B., Kaminski, M. S., Karimi, Y., Kelsey, C. R., King, R., Krivacic, S., LaCasce, A. S., Lim, M., Messmer, M., Narkhede, M., Rabinovitch, R., Ramakrishnan, P., Reid, E., Roberts, K. B., Saeed, H., Smith, S. D., Svoboda, J., Swinnen, L. J., Tuscano, J., Vose, J. M., Dwyer, M. A., & Sundar, H.
Affiliations
  • Memorial Sloan Kettering Cancer Center
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University
  • Massachusetts General Hospital Cancer Center
  • Stanford Cancer Institute
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine
  • City of Hope National Medical Center
  • Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute
  • University of Wisconsin Carbone Cancer Center
  • The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute
  • UCLA Jonsson Comprehensive Cancer Center
  • Vanderbilt-Ingram Cancer Center
  • The University of Texas MD Anderson Cancer Center
  • Mayo Clinic Comprehensive Cancer Center
  • St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center
  • Roswell Park Comprehensive Cancer Center
  • Huntsman Cancer Institute at the University of Utah
  • University of Michigan Rogel Cancer Center
  • Duke Cancer Institute
  • Consultant
  • Dana-Farber/Brigham and Women’s Cancer Center
  • Fox Chase Cancer Center
  • O’Neal Comprehensive Cancer Center at UAB
  • University of Colorado Cancer Center
  • UT Southwestern Simmons Comprehensive Cancer Center
  • UC San Diego Moores Cancer Center
  • Yale Cancer Center/Smilow Cancer Hospital
  • Moffitt Cancer Center
  • Fred Hutchinson Cancer Center
  • Abramson Cancer Center at the University of Pennsylvania
  • The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • UC Davis Comprehensive Cancer Center
  • Fred & Pamela Buffett Cancer Center
  • National Comprehensive Cancer Network
Venue
Journal of the National Comprehensive Cancer Network
Published
2023-11
Volume
21
Issue
11
Pages
1118-1131
ISSN
  • 1540-1405
  • 1540-1413
Cited by
131
References
3

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CoChat. (2026). Citation check: NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023: Featured Updates to the NCCN Guidelines. https://app.cochat.ai/papers/10.6004/jnccn.2023.0057
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Zelenetz, A. D., Gordon, L. I., Abramson, J. S., Advani, R. H., Andreadis, B., Bartlett, N. L., Budde, L. E., Caimi, P. F., Chang, J. E., Christian, B., DeVos, S., Dholaria, B., Fayad, L. E., Habermann, T. M., Hamid, M. S., Hernandez-Ilizaliturri, F., Hu, B., Kaminski, M. S., Karimi, Y., . . . Sundar, H. (2023). NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023: Featured Updates to the NCCN Guidelines. Journal of the National Comprehensive Cancer Network. https://doi.org/10.6004/jnccn.2023.0057

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