Linking bone marrow fat with decreased bone mineral density among Indian patients with osteoporotic fracture
Open accessAbstract
Osteoporosis is a systemic skeletal disorder with low-bone mass causing micro-architectural deterioration and an increase in bone fragility and susceptibility to fractures. According to a worldwide report by IOF, 1 in 3 females and 1 in 5 males will experience fractures due to the osteoporotic changes in their bones. Fractures may be the first clinical manifestation of the disease. They have been causes for morbidity and mortality imposing economic burden to osteoporosis. Bone marrow fat is a negative regulator of bone-turnover and a key integrator of bone and energy metabolism. Hence we assess the bone marrow fat and BMD in patients with osteoporotic bone fractures. This cross-sectional study was conducted in 30 patients from the department of orthopaedic surgery. Biopsy samples were received from excised bone during surgery. Biochemical parameters and bone marrow fat were quantified by established methods. A negative correlation between BMD versus serum adiponectin, FGF21 and similar observation with BMD versus bone marrow fat is seen. Therefore, increased bone-marrow fat and adiponectin, FGF21 levels and decreased BMD in osteoporosis. This observation might be useful for prevention, management and therapeutic potential of osteoporosis. Based on our study findings, understand the bone-fat relationship to implications with low BMD in patients with osteoporosis.
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AD mice at a younger age recapitulate an aged skeletal phenotype.
“As aging-related osteoporosis typically features low bone mass, microarchitectural alterations and bone marrow adipose tissue expansion40–42, our findings suggest that AD mice at a younger age recapitulate an aged skeletal phenotype.”
From Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis (2025) · cites this paper as [42]
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Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis
Kumar, S., Song, K., Wang, J., Baghel, M. S., Zeng, Y., Shen, K., Zheng, J., Crane, J., Demehri, S., Gao, P., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00924-z · Cited by 16 · see citing works
“Another potential source of the increased human Aβ 40 and Aβ 42 in mouse bone marrow could be circulating Aβ peptides, which might be released from the brain and transported across the blood–brain barrier into the bloodstream.”
Liu, J., Jiang, J., Li, Y., Chen, Q., Yang, T., Lei, Y., He, Z., Wang, X., Na, Q., Lao, C., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1439255 · Cited by 9 · see citing works
“This suggests FGF21 can decrease the bone mineral density, thus increasing the risk of osteoporosis, which is consistent with the predecessors ’ research results (15).”
ResultApplication of artificial intelligence in osteoporosis: a review
Fan, S.-T., Lu, M.-S., Dong, J.-L., Li, Y.-L., Hao, L.-N., Dong, R.-C., & Hou, M.-D. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1718554 · Cited by 4 · see citing works
Zhang, X.-T. (2026) · Traditional Chinese Medicine · doi:10.12677/tcm.2026.158428
- Authors
- Department of Biochemistry, D. S. M. C. A. H., & Paranthaman, M.
- Affiliations
- Tamil Nadu Dr. M.G.R. Medical University (IN)
- Corresponding author
- Paranthaman, Modagan
- Venue
- Bioinformation
- Publisher
- Biomedical Informatics
- Published
- 2024-01-31
- Volume
- 20
- Issue
- 1
- Pages
- 49-53
- ISSN
- 0973-2063 (ISSN-L)
- 0973-8894
- PMC
- PMC10859945
- OpenAlex
- W4391648731
- Cited by
- 5
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Bioinformation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- bone marrow fat, bone mineral density, osteoporotic fractures, osteoporosis, adiponectin, FGF21, bone biopsy, bone turnover, Indian patients
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