The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.
Fundamentals of clinical trial design
Open accessAbstract
Most errors in clinical trials are a result of poor planning. Fancy statistical methods cannot rescue design flaws. Thus careful planning with clear foresight is crucial. Issues in trial conduct and analyses should be anticipated during trial design and thoughtfully addressed. Fundamental clinical trial design issues are discussed.
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“Only trial designs that allow for the isolation of the effects of CBT will be included given it is important for active comparators to discriminate intervention effects.59”
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“This problem is particularly acute in neurology, where outcomes may be highly variable (e.g., in cognition), susceptible to the state of the patient (e.g., fatigue, pain, anxiety, depression), the lack of a gold standard definition or diagnosis (e.g., neuropathy, dementia), are high dimensional (e.g., imaging or genomic markers), or are composite in nature (e.g., clinical instruments for assessing”
From QSAR without borders (2020) · cites this paper as [270]
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Fundamentals of Clinical Trials
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Research works printed but not linked: 1
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Muratov, E. N., Bajorath, J., Sheridan, R. P., Tetko, I. V., Filimonov, D., Poroikov, V., Oprea, T. I., Baskin, I. I., Varnek, A., Roitberg, A., et al. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00098a · Cited by 913
Strategies for dealing with missing data in clinical trials: from design to analysis.
(2013) · PubMed Central · Cited by 288
Hiller, J. G., Cole, S. W., Crone, E. M., Byrne, D. J., Shackleford, D. M., Pang, J.-M. B., Henderson, M. A., Nightingale, S. S., Ho, K. M., Myles, P. S., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2641 · Cited by 223
Weiner, D. L., Balasubramaniam, V., Shah, S. I., & Javier, J. R. (2020) · Pediatric Research · doi:10.1038/s41390-020-1006-3 · Cited by 130
Pettman, D., O’Mahen, H., Blomberg, O., Svanberg, A. S., von Essén, L., & Woodford, J. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04547-9 · Cited by 90
Metadata
- Authors
- Evans, S. R.
- Affiliations
- Harvard University (US)
- Corresponding author
- Evans, Scott R.
- ORCID
- Evans, Scott R.
- Venue
- Journal of Experimental Stroke and Translational Medicine
- Publisher
- OMICS Publishing Group
- Published
- 2010-01
- Volume
- 3
- Issue
- 1
- Pages
- 19-27
- ISSN
- 1939-067X (ISSN-L)
- PMC
- PMC3083073
- OpenAlex
- W2088245419
- Cited by
- 119
- References
- 20
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 39 · 2023: 17 · 2022: 11 · 2021: 14 · 2020: 11 · 2019: 6 · 2018: 2 · 2016: 1 · 2013: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Experimental Stroke and Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- National Institute of Allergy and Infectious Diseases (U01AI068634, UM1AI068634)
- National Institute of Neurological Disorders and Stroke (R01NS032228, U01NS032228)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Keywords
- clinical trial design, trial planning, design errors, trial conduct, statistical analysis planning, stroke research
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