Comparison of pre- and post-levothyroxine high-sensitivity c-reactive protein and fetuin-a levels in subclinical hypothyroidism
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OBJECTIVE: The objective of this trial was to determine the levels of inflammatory markers, high-sensitivity C-reactive protein and fetuin-A pre- and post-levothyroxine treatment in cases of subclinical hypothyroidism. MATERIALS AND METHODS: A total of 32 patients with a diagnosis of subclinical hypothyroidism and a control group of 30 healthy individuals were tested for high-sensitivity C-reactive protein and fetuin-A, followed by the administration of 50 µg of levothyroxine in the patient group for 3 months. During the post-treatment stage, high-sensitivity C-reactive protein and fetuin-A levels in the patient group were re-assessed and compared with pre-treatment values. RESULTS: Pre-treatment levels of both high-sensitivity C-reactive protein and fetuin-A were observed to be higher in the patient group than in the control group. The decrease in high-sensitivity C-reactive protein levels during the post-treatment stage was not statistically significant. However, the decrease observed in post-treatment fetuin-A levels was found to be statistically significant. CONCLUSION: The decrease in fetuin-A levels in subclinical hypothyroidism cases indicates that levothyroxine treatment exerts anti-inflammatory and anti-apoptotic effects. Although the decrease in high-sensitivity C-reactive protein levels was statistically non-significant, it is predicted to reach significance with sustained treatment.
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Circulating levels of inflammatory cytokines were increased in hypothyroidism and reduced after treatment with LT4 in a randomised, placebo-controlled trial and in an observational study.
“Circulating levels of inflammatory cytokines were increased in hypothyroidism and reduced after treatment with LT4 in a randomised, placebo-controlled trial [100] and in an observational study [101].”
From Pharmacodynamic and Therapeutic Actions of Levothyroxine (2021) · cites this paper as [101]
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References 37 · Cited by 54
- Authors
- Bilgir, O., Bilgir, F., Calan, M., Calan, O. G., & Yuksel, A.
- Affiliations
- Izmir Bozyaka Eğitim ve Araştırma Hastanesi (TR)
- Izmir Kâtip Çelebi University (TR)
- Corresponding author
- Bilgir, Oktay
- Bilgir, Ferda
- Venue
- Clinics
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 70
- Issue
- 2
- Pages
- 97-101
- ISSN
- 1807-5932 (ISSN-L)
- PMC
- PMC4351305
- OpenAlex
- W2004676096
- Cited by
- 54
- References
- 37
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 17 · 2021: 17 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinics (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- subclinical hypothyroidism, levothyroxine, high-sensitivity C-reactive protein, fetuin-A, inflammatory markers, anti-inflammatory activity, anti-apoptotic effects, thyroid hormone replacement
- MeSH terms
- Adult, C-Reactive Protein, Follow-Up Studies, Humans, Hypothyroidism, Luminescent Measurements, Middle Aged, Thyrotropin, Thyroxine, Biomarkers, Case-Control Studies, alpha-2-HS-Glycoprotein
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