Metabolic effects of polycystic ovary syndrome in adolescents
Open accessAbstract
PURPOSE: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenic anovulation in women of reproductive age. We investigated the metabolic effects of lean and overweight adolescents with PCOS. METHODS: Anthropometric measurements and biochemical parameters were evaluated in 49 adolescents with PCOS and 40 age- and body mass index (BMI)-matched controls. We further divided both PCOS and control groups into those having BMI within the normal range of less than 85(th) percentile and those being overweight and obese with a BMI greater than 85(th) percentile. RESULTS: Hemoglobin, gamma-glutamyl transferase (r-GT), total cholesterol, low-density lipoprotein-cholesterol and 2-hour postglucose load plasma insulin levels were significantly elevated in the lean PCOS group than in the lean control group. In the overweight/obese PCOS group, hemoglobin and r-GT levels were significantly elevated than in the overweight/obese control group. In the normal weight group, none of the subjects had metabolic syndrome according to the Adult Treatment Panel III criteria, but the incidence of metabolic syndrome in the overweight/obese PCOS group was 8.3% and that in the overweight/obese control group was 6.7%. CONCLUSION: PCOS in adolescents causes metabolic abnormalities, underscoring the importance of early diagnosis of PCOS in oligomenorrheic adolescents.
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Lean PCOS patients have increased plasma insulin 2 h after glucose administration compared with lean healthy participants.
“Several reports showed the different metabolic disturbances characteristics in PCOS patients, like increased plasma insulin levels 2 h after glucose administration to lean PCOS patients, correlated with the lean, healthy participants.”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [55]
Lean PCOS women have increased LDL and total cholesterol compared with controls.
“Also, important risen low-density lipoprotein (LDL) and total cholesterol have been associated in lean PCOS women versus controls [1,30,55].”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [55]
In women with PCOS, circulating hemoglobin and hematocrit are reported as not or marginally increased.
“In women with the mild hyperandrogenism of PCOS, circulating hemoglobin and hematocrit are reported as not (129) or marginally increased (130), findings that may be influenced by the fact that PCOS is associated with reduced or absent menstruation, thereby reducing the iron loss of regular menstruation.”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [130]
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References 47 · Cited by 22
- Authors
- Han, Y., Kim, H. S., Lee, H.-J., Oh, J.-Y., & Sung, Y.-A.
- Affiliations
- Ewha Womans University (KR)
- Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
- Corresponding author
- Kim, Hae Soon
- Venue
- Annals of Pediatric Endocrinology & Metabolism
- Published
- 2015
- Volume
- 20
- Issue
- 3
- Pages
- 136
- ISSN
- 2287-1012 (ISSN-L)
- 2287-1292
- PMC
- PMC4623341
- OpenAlex
- W2158437711
- Cited by
- 22
- References
- 47
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 4 · 2018: 3 · 2017: 2 · 2016: 1
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Annals of Pediatric Endocrinology & Metabolism (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, adolescents, metabolic syndrome, overweight, obesity, hyperandrogenism, anovulation, insulin resistance, dyslipidemia, gamma-glutamyl transferase, hemoglobin, oligomenorrhea, early diagnosis
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