Effects of growth hormone on glucose metabolism and insulin resistance in human
Open accessAbstract
Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and pancreas either directly or indirectly through insulin-like growth factor 1. The diabetogenic action of GH has been well-described in previous in vivo studies. In this paper, we review the metabolic effects of GH on peripheral tissues focusing on glucose metabolism and insulin resistance, and discuss results from human studies on the long-term effects of GH administration on insulin resistance and hyperglycemia.
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Insulin secretion is enhanced for compensation of elevated blood glucose after GH administration.
“Insulin secretion is also enhanced for the compensation of elevated blood glucose after GH administration (50).”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [50]
GH can elevate glucose production in skeletal muscle and liver and diminish glucose utilization in adipose tissue by antagonizing action of insulin.
“GH can elevate glucose production in the skeletal muscle and liver and diminish glucose utilization in adipose tissue by antagonizing the action of insulin.”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [50]
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References 58 · Cited by 181
- Authors
- Kim, S.-H., & Park, M.-J.
- Affiliations
- Inje University Sanggye Paik Hospital (KR)
- Corresponding author
- Park, Mi-Jung
- Venue
- Annals of Pediatric Endocrinology & Metabolism
- Published
- 2017-09-30
- Volume
- 22
- Issue
- 3
- Pages
- 145-152
- ISSN
- 2287-1012 (ISSN-L)
- 2287-1292
- PMC
- PMC5642081
- OpenAlex
- W2760490858
- Cited by
- 181
- References
- 58
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 23 · 2023: 24 · 2022: 35 · 2021: 19 · 2020: 19 · 2019: 16 · 2018: 14 · 2017: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Annals of Pediatric Endocrinology & Metabolism (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- growth hormone, glucose metabolism, insulin resistance, hyperglycemia, insulin-like growth factor I, diabetogenic effect, physical growth
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