Evaluation of the Relationship between Endometriosis and Omega-3 and Omega-6 Polyunsaturated Fatty Acids
Open accessAbstract
BACKGROUND: Endometriosis is a common chronic inflammation causing major problems including infertility. The role of omega-3 and omega-6 fatty acids as their potential anti-inflammatory effects in endometriosis needs to be further explored. The objective of this study was to compare serum phospholipid fatty acid profile in endometriosis patients with controls, and to explore the correlation of this profile with the severity of the disease. METHODS: Sixty-four endometriosis patients and 74 control women, in reproductive age, participated in this study. Among the endometriosis patients, 19 cases were in stage I, 27 cases in stage II, 8 cases in stage III, and 10 cases in stage IV. Each patient underwent laparoscopy. Before surgery, 5 ml of blood was obtained. After extraction of the total lipids, serum total phospholipid fraction was isolated by thin layer chromatography. Fatty acid composition of the phospholipid fraction was determined by gas chromatography and the resulted profile was compared in endometriosis patients and controls. The profile was also compared in the endometriosis group based on the severity of disease. RESULTS: Stearic acid was significantly lower in the endometriosis group as compared to controls (P= 0.030). No other fatty acid compositions were significantly different between patients and controls. Serum ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) was in reasonable correlation with the severity of endometriosis (r = 0.34, P = 0.006). CONCLUSION: According to these findings, levels of fatty acids in serum total phospholipids seem not to be a marker for endometriosis, but the EPA to AA ratio was a relevant factor indicating severity of illness.
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Stearic acid was significantly reduced (P=0.030) in endometriosis patients (n=64) compared with controls (n=74).
“Stearic acid was significantly reduced (P = 0.030) in endometriosis patients (n = 64) compared with controls (n = 74) [92].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [92]
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References 28 · Cited by 42
Research works printed but not linked: 3
- [15]15. Bligh EG, Dyer WJ. Extraction of Lipids in Solution by the Method of Bligh & Dyer. Can J Biochem Physiol.1959 Aug;37(8):911-7 .
- [16]16. Carl AB, Edward RA, David EB. TIETZ text book of clinical chemistry and molecular diagnostics. 1,4 th ed. Washington DC: Elsevier; USA; 2006. p.148-9.
- [13]13. in culture medium reduce endometrial cell survival in combined endometrial gland and stromal cell cultures from women with and without endometriosis. Fertil Steril.2001 Oct;76(4):717-22 .
- Authors
- Khanaki, K., Nouri, M., Ardekani, A. M., Ghassemzadeh, A., Shahnazi, V., Sadeghi, M. R., Darabi, M., Mehdizadeh, A., Dolatkhah, H., Saremi, A., Imani, A. R., & Rahimipour, A.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Academic Center for Education, Culture and Research (IR)
- Sarem Cell Research Center (IR)
- Tehran University of Medical Sciences (IR)
- ORCID
- Venue
- the Pasteur Institute of Iran
- Publisher
- the Pasteur Institute of Iran
- Published
- 1996
- Volume
- 16
- Issue
- 1
- Pages
- 38-43
- PMC
- PMC3614254
- OpenAlex
- W2130406426
- Cited by
- 42
- References
- 28
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 3 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- Tabriz University of Medical Sciences
- University of Tabriz
- Alzahra University
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- endometriosis, omega-3 fatty acids, omega-6 fatty acids, eicosapentaenoic acid, arachidonic acid, disease severity, stearic acid, anti-inflammatory activity, chronic inflammation, infertility
- MeSH terms
- Adolescent, Adult, Endometriosis, Female, Humans, Inflammation, Eicosapentaenoic Acid, Biomarkers, Fatty Acids, Omega-3, Arachidonic Acid, Inflammation Mediators, Fatty Acids, Omega-6, Young Adult
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