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PreprintCited by 1Physiological and biochemical adaptationsNeuropeptides and Animal PhysiologyNeurobiology and Insect Physiology Research

Quantitative Neuropeptidomics Reveals Thermal Acclimation-Induced Remodeling of Peptidergic Signaling in the American Lobster Homarus americanus

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Tran, Vu Ngoc Huong, Kedia, Sonal, Lu, Gaoyuan, Selby, Kendra G., Duong, Thao, Del Mundo, Zachary, Marder, Eve, Li, Lingjun·2026·bioRxiv (Cold Spring Harbor Laboratory)
DOI 10.64898/2026.03.07.710231PMC PMC13060937
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Abstract

Global warming and rising ocean temperatures pose substantial challenges to marine ecosystems and crustacean populations. As an ectothermic species, the American lobster ( Homarus americanus ) relies on physiological and neurochemical mechanisms to maintain homeostasis under varying environmental conditions. To elucidate the role of neuropeptides in neuronal plasticity and systemic adaptation to temperature fluctuations, we employed a quantitative mass spectrometry-based approach to probe key neuropeptides involving thermal adaptation in four lobster neural tissues at three temperatures: 4 °C (cold), 11 °C (control), and 18 °C (warm). Peptidomic profiling revealed a global reduction in peptide abundance during cold exposure, alongside coordinated, tissue-specific reconfigurations of the neuropeptidome between experimental groups. Cold exposure led to a significant downregulation of RFamide, leucokinin, and pyrokinin peptides in the commissural ganglia, whereas B-type allatostatin (AST-B), natalisin, and RYamide peptides were drastically elevated in the brain of warm-acclimated animals, with comparatively fewer detectable peptide abundance changes in the sinus gland and the stomatogastric ganglion. Collectively, our findings elucidate neuropeptide signaling pathways underlying thermal tolerance and adaptive resilience in Homarus americanus , offering insights into the survival mechanism and neurochemical basis of neural circuits in response to thermal acclimation. Abstract Figure:

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  • By monitoring ocean temperatures, it is possible to ask mechanistic questions about how nervous systems from wild-caught animals are altered by the environment.

    “By monitoring the ocean temperatures, it is possible to ask mechanistic questions about how nervous systems from wild-caught animals are altered by the environment [67][68][69][70].”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [69]

    The Introduction says the study probes how temperature affects lobster neural systems, and Animals and Tissue Collection describes analysis of neural tissues after acclimation at three temperatures. But the researchers used controlled laboratory temperatures, not monitored ocean temperatures; that section says the lobsters were purchased commercially and does not establish that they were wild-caught. Our copy provides no page numbers for these passages. (LLM, conf=0.84)

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Research works printed but not linked: 61

  1. Christogianni, A.; Bibb, R.; Davis, S. L.; Jay, O.; Barnett, M.; Evangelou, N.; Filingeri, D. Temperature sensitivity in multiple sclerosis: An overview of its impact on sensory and cognitive symptoms. Temperature 2018, 5 (3), 208-223. https://doi.org/10.1080/23328940.2018.1475831 · DOI
  2. Peters, C.; Rosch, R. E.; Hughes, E.; Ruben, P. C. Temperature-dependent changes in neuronal dynamics in a patient with an SCN1A mutation and hyperthermia induced seizures. Scientific Reports 2016, 6 (1), 31879. https://doi.org/10.1038/srep31879 · DOI
  3. Chen, N.-T.; Lin, P.-H.; Guo, Y.-L. L. Long-term exposure to high temperature associated with the incidence of major depressive disorder. Science of The Total Environment 2019, 659, 1016-1020. https://doi.org/10.1016/j.scitotenv.2018.12.434 · DOI · Paper page
  4. Danh, N.; Ho, C.; Ford, E.; Zhang, J.; Hong, H.; Reid, C.; Xu, D. Association between ambient temperature and stroke risk in high-risk populations: a systematic review. Frontiers in Neurology 2024, Volume 14 -2023. https://doi.org/10.3389/fneur.2023.1323224 · DOI
  5. Delaney, S. W.; Stegmuller, A.; Mork, D.; Mock, L.; Bell, M. L.; Gill, T. M.; Braun, D.; Zanobetti, A. Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias. JAMA Internal Medicine 2025, 185 (4), 412-421. https://doi.org/10.1001/jamainternmed.2024.7719 · DOI
  6. Jovanovic, P.; Pool, A.-H.; Morones, N.; Wang, Y.; Novinbakht, E.; Keshishian, N.; Jang, K.; Oka, Y.; Riera, C. E. A sex-specific thermogenic neurocircuit induced by predator smell recruiting cholecystokinin neurons in the dorsomedial hypothalamus. Nature Communications 2023, 14 (1), 4937. https://doi.org/10.1038/s41467-023- 40484-7 · DOI
  7. Kehoe, A. S.; Volkoff, H. The Effects of Temperature on Feeding and Expression of Two Appetite-related Factors, Neuropeptide Y and Cocaine-and Amphetamine-regulated Transcript, in Atlantic Cod, Gadus morhua. Journal of the World Aquaculture Society 2008, 39 (6), 790-796. https://doi.org/10.1111/j.1749-7345.2008.00215.x · DOI
  8. Wang, X.; Wang, Q.; Zhao, M.; Xu, Y.; Fu, B.; Zhang, L.; Wu, S.; Yang, D.; Jia, C. Cold Exposure- induced Alterations in the Brain Peptidome and Gut Microbiome Are Linked to Energy Homeostasis in Mice. Molecular & Cellular Proteomics 2023, 22 (4), 100525. https://doi.org/10.1016/j.mcpro.2023.100525 · DOI
  9. Spencer, K. A.; Belgacem, Y. H.; Visina, O.; Shim, S.; Genus, H.; Borodinsky, L. N. Growth at Cold Temperature Increases the Number of Motor Neurons to Optimize Locomotor Function. Current Biology 2019, 29 (11), 1787-1799.e5. https://doi.org/10.1016/j.cub.2019.04.072 · DOI
  10. Nguyen, M. V.; Pham, L. P.; Jordal, A. E. O.; Espe, M.; Conceição, L. E. C.; Yúfera, M.; Engrola, S.; Le, M. H.; Rønnestad, I. Elevated sea temperature combined with dietary methionine levels affect feed intake and appetite-related neuropeptide expression in the brains of juvenile cobia (Rachycentron canadum). Frontiers in Marine Science 2023, Volume 10 -2023. https://doi.org/10.3389/fmars.2023.1183967 · DOI
  11. Poloczanska, E. S.; Burrows, M. T.; Brown, C. J.; García Molinos, J.; Halpern, B. S.; Hoegh-Guldberg, O.; Kappel, C. V.; Moore, P. J.; Richardson, A. J.; Schoeman, D. S.; Sydeman, W. J. Responses of Marine Organisms to Climate Change across Oceans. Frontiers in Marine Science 2016, Volume 3 -2016. https://doi.org/10.3389/fmars.2016.00062 · DOI
  12. DeMaegd, M. L.; Stein, W. Neuropeptide Modulation Increases Dendritic Electrical Spread to Restore Neuronal Activity Disrupted by Temperature. The Journal of Neuroscience 2021, 41 (36), 7607. https://doi.org/10.1523/JNEUROSCI.0101-21.2021 · DOI
  13. Van Hook, M. J. Temperature effects on synaptic transmission and neuronal function in the visual thalamus. PLOS ONE 2020, 15 (4), e0232451. https://doi.org/10.1371/journal.pone.0232451 · DOI
  14. Szabo, T. M.; Brookings, T.; Preuss, T.; Faber, D. S. Effects of temperature acclimation on a central neural circuit and its behavioral output. J Neurophysiol 2008, 100 (6), 2997-3008. https://doi.org/10.1152/jn.91033.2008 · DOI
  15. Klymasz-Swartz, A. K.; Allen, G. J. P.; Treberg, J. R.; Yoon, G. R.; Tripp, A.; Quijada-Rodriguez, A. R.; Weihrauch, D. Impact of climate change on the American lobster (Homarus americanus): Physiological responses to combined exposure of elevated temperature and pCO2. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 2019, 235, 202-210. https://doi.org/10.1016/j.cbpa.2019.06.005 · DOI
  16. Lorenzon, S.; Giulianini, P. G.; Martinis, M.; Ferrero, E. A. Stress effect of different temperatures and air exposure during transport on physiological profiles in the American lobster Homarus americanus. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 2007, 147 (1), 94-102. https://doi.org/10.1016/j.cbpa.2006.11.028 · DOI
  17. Camacho, J.; Qadri, S. A.; Wang, H.; Worden, M. K. Temperature acclimation alters cardiac performance in the lobster Homarus americanus. Journal of Comparative Physiology A 2006, 192 (12), 1327-1334. https://doi.org/10.1007/s00359-006-0162-1 · DOI
  18. Quinn, B. K.; Rochette, R.; Ouellet, P.; Sainte-Marie, B. Effect of Temperature on Development Rate of Larvae from Cold-Water American Lobster (Homarus Americanus). Journal of Crustacean Biology 2013, 33 (4), 527- 536. https://doi.org/10.1163/1937240X-00002150 · DOI
  19. Wang, G.; Robertson, L. M.; Wringe, B. F.; McGaw, I. J. The Effect of Temperature on Foraging Activity and Digestion in the American Lobster Homarus Americanus (Milne Edwards, 1837) (Decapoda: Nephropsidae) Feeding on Blue mussels Mytilus Edulis (Linnaeus, 1758). Journal of Crustacean Biology 2016, 36 (2), 138-146. https://doi.org/10.1163/1937240X-00002414 · DOI
  20. Johnson, B. R.; Peck, J. H.; Harris-Warrick, R. M. Temperature Sensitivity of Graded Synaptic Transmission in the Lobster Stomatogastric Ganglion. Journal of Experimental Biology 1991, 156 (1), 267-285. https://doi.org/10.1242/jeb.156.1.267 · DOI
  21. Marder, E.; Haddad, S. A.; Goeritz, M. L.; Rosenbaum, P.; Kispersky, T. How can motor systems retain performance over a wide temperature range? Lessons from the crustacean stomatogastric nervous system. Journal of Comparative Physiology A 2015, 201 (9), 851-856. https://doi.org/10.1007/s00359-014-0975-2 · DOI
  22. Lee, M.; Marder, E. Increased robustness and adaptation to simultaneous temperature and elevated extracellular potassium in the pyloric rhythm of the crab, Cancer borealis. Journal of Neurophysiology 2024, 133 (2), 561-571. https://doi.org/10.1152/jn.00410.2024 · DOI
  23. Carrier, K. L.; Romano, N.; Scaria, L. K.; Palmer, M.; O'Leary, R. M.; Marder, E.; Powell, D. J. The combined effects of temperature and salinity on the stomatogastric nervous system of two species of decapod crustacea. Journal of Neurophysiology 2026. https://doi.org/10.1152/jn.00294.2025 · DOI
  24. Hampton, D.; Kedia, S.; Marder, E. Alterations in network robustness upon simultaneous temperature and pH perturbations. Journal of Neurophysiology 2024, 131 (3), 509-515. https://doi.org/10.1152/jn.00483.2023 · DOI
  25. Fields, L.; Dang, T. C.; Tran, V. N. H.; Ibarra, A. E.; Li, L. Decoding Neuropeptide Complexity: Advancing Neurobiological Insights from Invertebrates to Vertebrates through Evolutionary Perspectives. ACS Chemical Neuroscience 2025, 16 (9), 1662-1679. https://doi.org/10.1021/acschemneuro.5c00053 · DOI
  26. Lu, G.; Tran, V. N. H.; Wu, W.; Ma, M.; Li, L. Neuropeptidomics of the American Lobster Homarus americanus. Journal of Proteome Research 2024, 23 (5), 1757-1767. https://doi.org/10.1021/acs.jproteome.3c00925 · DOI
  27. Tran, V. N. H.; Lu, G.; Duong, T.; Ibarra, A. E.; Wu, F.; Beaver, M.; Li, L. HILIC-Enabled Mass Spectrometric Discovery of Novel Endogenous and Glycosylated Neuropeptides in the American Lobster Nervous System. bioRxiv 2025. https://doi.org/10.1101/2025.06.26.661634 · DOI
  28. Ma, M.; Chen, R.; Sousa, G. L.; Bors, E. K.; Kwiatkowski, M. A.; Goiney, C. C.; Goy, M. F.; Christie, A. E.; Li, L. Mass spectral characterization of peptide transmitters/hormones in the nervous system and neuroendocrine organs of the American lobster Homarus americanus. General and Comparative Endocrinology 2008, 156 (2), 395-409. https://doi.org/10.1016/j.ygcen.2008.01.009 · DOI
  29. Lu, G.; Frézier, M.; Otis, C.; Tran, V. N. H.; Lussier, B.; Saint-Jean, G.; Beaudry, H.; Troncy, E.; Li, L. Global spinal cord peptidome profiling in response to osteoarthritis in rats. Molecular Omics 2025, 21 (6), 645-656. http://dx.doi.org/10.1039/D5MO00152H · DOI
  30. Lu, G.; Ma, F.; Wei, P.; Ma, M.; Tran, V. N. H.; Baldo, B. A.; Li, L. Cocaine-Induced Remodeling of the Rat Brain Peptidome: Quantitative Mass Spectrometry Reveals Anatomically Specific Patterns of Cocaine-Regulated Peptide Changes. ACS Chemical Neuroscience 2025, 16 (2), 128-140. https://doi.org/10.1021/acschemneuro.4c00327 · DOI
  31. DeLaney, K.; Hu, M.; Hellenbrand, T.; Dickinson, P. S.; Nusbaum, M. P.; Li, L. Mass Spectrometry Quantification, Localization, and Discovery of Feeding-Related Neuropeptides in Cancer borealis. ACS Chemical Neuroscience 2021, 12 (4), 782-798. https://doi.org/10.1021/acschemneuro.1c00007 · DOI
  32. Buchberger, A. R.; Delaney, K.; Liu, Y.; Vu, N. Q.; Helfenbein, K.; Li, L. Mass Spectrometric Profiling of Neuropeptides in Callinectes sapidus during Hypoxia Stress. ACS Chemical Neuroscience 2020, 11 (19), 3097- 3106. https://dx.doi.org/10.1021/acschemneuro.0c00439 · DOI
  33. Sauer, C. S.; Li, L. Mass Spectrometric Profiling of Neuropeptides in Response to Copper Toxicity via Isobaric Tagging. Chemical Research in Toxicology 2021, 34 (5), 1329-1336. https://doi.org/10.1021/acs.chemrestox.0c00521 · DOI
  34. Liu, Y.; Buchberger, A. R.; DeLaney, K.; Li, Z.; Li, L. Multifaceted Mass Spectrometric Investigation of Neuropeptide Changes in Atlantic Blue Crab, Callinectes sapidus, in Response to Low pH Stress. Journal of Proteome Research 2019, 18 (7), 2759-2770. https://doi.org/10.1021/acs.jproteome.9b00026 · DOI
  35. Tran, V. N. H.; Duong, T. U.; Fields, L.; Tourlouskis, K.; Beaver, M.; Li, L. cNPDB: A comprehensive empirical crustacean neuropeptide database. bioRxiv 2025. https://doi.org/10.1101/2025.07.29.667494 · DOI
  36. Wong, T. H. H.; Chow, L. H.; Hui, T. K. L.; Ma, K. Y.; Tsang, L. M.; Leung, R. W. T.; Qin, J. Neuropeptide Diversity and Evolutionary Patterns in Crustaceans: Insights into Adaptations, Agonism, and Functional Importance in Organs. Research Square 2026. https://doi.org/10.21203/rs.3.rs-8566760/v1 · DOI
  37. Marder, E. Neuromodulation of Neuronal Circuits: Back to the Future. Neuron 2012, 76 (1), 1-11. https://doi.org/10.1016/j.neuron.2012.09.010 · DOI · Paper page
  38. Phetsanthad, A.; Vu, N. Q.; Yu, Q.; Buchberger, A. R.; Chen, Z.; Keller, C.; Li, L. Recent advances in mass spectrometry analysis of neuropeptides. Mass spectrometry reviews 2021, e21734. https://doi.org/10.1002/mas.21734 · DOI
  39. Fricker, L. D., Eds. Springer US: New York, NY, 2024; pp 255-289.https://doi.org/10.1007/978-1-0716-3646-6_14 · DOI
  40. Chen, R.; Xiao, M.; Buchberger, A.; Li, L. Quantitative Neuropeptidomics Study of the Effects of Temperature Change in the Crab Cancer borealis. Journal of Proteome Research 2014, 13 (12), 5767-5776. https://doi.org/10.1021/pr500742q · DOI
  41. Mousavi, S.; Qiu, H.; Andrews, M. T.; Checco, J. W. Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal. ACS Chemical Neuroscience 2023, 14 (14), 2569-2581. https://doi.org/10.1021/acschemneuro.3c00268 · DOI
  42. Lawton, P.; Lavalli, K. L., Chapter 4 -Postlarval, Juvenile, Adolescent, and Adult Ecology. In Biology of the Lobster, Factor, J. R., Ed. Academic Press: San Diego, 1995; pp 47- 88.https://www.sciencedirect.com/science/article/pii/B9780122475702500268
  43. Crossin, G. T.; Al-Ayoub, S. A.; Jury, S. H.; Howell, W. H.; Watson, W. H., III Behavioral Thermoregulation in the American Lobster Homarus Americanus. Journal of Experimental Biology 1998, 201 (3), 365-374. https://doi.org/10.1242/jeb.201.3.365 · DOI
  44. Hook, V.; Lietz, C. B.; Podvin, S.; Cajka, T.; Fiehn, O. Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry. Journal of the American Society for Mass Spectrometry 2018, 29 (5), 807-816. https://doi.org/10.1007/s13361-018-1914-1 · DOI
  45. Wiggenhorn, A. L.; Abuzaid, H. Z.; Coassolo, L.; Li, V. L.; Tanzo, J. T.; Wei, W.; Lyu, X.; Svensson, K. J.; Long, J. Z. A class of secreted mammalian peptides with potential to expand cell-cell communication. Nature Communications 2023, 14 (1), 8125. https://doi.org/10.1038/s41467-023-43857-0 · DOI
  46. Nässel, D. R.; Wu, S.-F. Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression. Cellular and Molecular Life Sciences 2022, 79 (3), 188. https://doi.org/10.1007/s00018-022-04214-4 · DOI
  47. Chang, E. S. Stressed-Out Lobsters: Crustacean Hyperglycemic Hormone and Stress Proteins. Integrative and Comparative Biology 2005, 45 (1), 43-50. https://doi.org/10.1093/icb/45.1.43 · DOI
  48. Lorenzon, S.; Edomi, P.; Giulianini, P. G.; Mettulio, R.; Ferrero, E. A. Variation of crustacean hyperglycemic hormone (cHH) level in the eyestalk and haemolymph of the shrimp Palaemon elegans following stress. Journal of Experimental Biology 2004, 207 (24), 4205-4213. https://doi.org/10.1242/jeb.01264 · DOI
  49. Chung, J. S.; Zmora, N. Functional studies of crustacean hyperglycemic hormones (CHHs) of the blue crab, Callinectes sapidus -the expression and release of CHH in eyestalk and pericardial organ in response to environmental stress. The FEBS Journal 2008, 275 (4), 693-704. https://doi.org/10.1111/j.1742-4658.2007.06231.x · DOI
  50. Alexander, J. L.; Oliphant, A.; Wilcockson, D. C.; Audsley, N.; Down, R. E.; Lafont, R.; Webster, S. G. Functional Characterization and Signaling Systems of Corazonin and Red Pigment Concentrating Hormone in the Green Shore Crab, Carcinus maenas. Frontiers in Neuroscience 2018, 11. https://doi.org/10.3389/fnins.2017.00752 · DOI
  51. Li, L.; Pulver, S. R.; Kelley, W. P.; Thirumalai, V.; Sweedler, J. V.; Marder, E. Orcokinin peptides in developing and adult crustacean stomatogastric nervous systems and pericardial organs. Journal of Comparative Neurology 2002, 444 (3), 227-244. https://doi.org/10.1002/cne.10139 · DOI
  52. Stemmler, E. A.; Peguero, B.; Bruns, E. A.; Dickinson, P. S.; Christie, A. E. Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs. Journal of Neurochemistry 2007, 101 (5), 1351-1366. https://doi.org/10.1111/j.1471-4159.2007.04520.x · DOI
  53. Hui, L.; Zhang, Y.; Wang, J.; Cook, A.; Ye, H.; Nusbaum, M. P.; Li, L. Discovery and Functional Study of a Novel Crustacean Tachykinin Neuropeptide. ACS Chemical Neuroscience 2011, 2 (12), 711-722. https://doi.org/10.1021/cn200042p · DOI
  54. Szabo, T. M.; Chen, R.; Goeritz, M. L.; Maloney, R. T.; Tang, L. S.; Li, L.; Marder, E. Distribution and physiological effects of B-type allatostatins (myoinhibitory peptides, MIPs) in the stomatogastric nervous system of the crab Cancer borealis. Journal of Comparative Neurology 2011, 519 (13), 2658-2676. https://doi.org/10.1002/cne.22654 · DOI
  55. Green, B. S.; Gardner, C.; Hochmuth, J. D.; Linnane, A. Environmental effects on fished lobsters and crabs. Reviews in Fish Biology and Fisheries 2014, 24 (2), 613-638. https://doi.org/10.1007/s11160-014-9350-1 · DOI
  56. Jiang, H.; Lkhagva, A.; Daubnerová, I.; Chae, H.-S.; Šimo, L.; Jung, S.-H.; Yoon, Y.-K.; Lee, N.-R.; Seong, J. Y.; Žitňan, D.; Park, Y.; Kim, Y.-J. Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects. Proceedings of the National Academy of Sciences 2013, 110 (37), E3526-E3534. https://doi.org/10.1073/pnas.1310676110 · DOI
  57. Marder, E., The Crustacean Stomatogastric Nervous System. In Handbook of Brain Microcircuits, Oxford University Press: 2017; p 0.https://doi.org/10.1093/med/9780190636111.003.0043 · DOI
  58. Jorge-Rivera, J. C.; Marder, E. TNRNFLRFamide and SDRNFLRFamide modulate muscles of the stomatogastric system of the crab Cancer borealis. Journal of Comparative Physiology A 1996, 179 (6), 741-751. https://doi.org/10.1007/BF00207353 · DOI
  59. Cruz-Bermúdez, N. D.; Fu, Q.; Kutz-Naber, K. K.; Christie, A. E.; Li, L.; Marder, E. Mass spectrometric characterization and physiological actions of GAHKNYLRFamide, a novel FMRFamide-like peptide from crabs of the genus Cancer. Journal of Neurochemistry 2006, 97 (3), 784-799. https://doi.org/10.1111/j.1471- 4159.2006.03747.x · DOI
  60. Saideman, S. R.; Christie, A. E.; Torfs, P.; Huybrechts, J.; Schoofs, L.; Nusbaum, M. P. Actions of kinin peptides in the stomatogastric ganglion of the crab Cancer borealis. Journal of Experimental Biology 2006, 209 (18), 3664-3676. https://doi.org/10.1242/jeb.02415 · DOI
  61. Fadda, M.; Hasakiogullari, I.; Temmerman, L.; Beets, I.; Zels, S.; Schoofs, L. Regulation of Feeding and Metabolism by Neuropeptide F and Short Neuropeptide F in Invertebrates. Frontiers in Endocrinology 2019, Volume 10 -2019. https://doi.org/10.3389/fendo.2019.00064 · DOI

Cited by

Sorted by citations

Authors
Tran, V. N. H., Kedia, S., Lu, G., Selby, K. G., Duong, T., Del Mundo, Z., Marder, E., & Li, L.
Affiliations
  • University of Wisconsin–Madison (US)
  • Brandeis University (US)
  • School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, United States
Corresponding author
Li, Lingjun
ORCID
Venue
bioRxiv (Cold Spring Harbor Laboratory)
Publisher
openRxiv
Published
2026-03-10
DOI
10.64898/2026.03.07.710231
PMC
PMC13060937
OpenAlex
W7134925877
Cited by
1
References
0
Citations by year
2026: 1
Type
posted content
Language
en
Open access
Licence
www.biorxiv.org/about/FAQ#license (vor)
Locations
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (submittedVersion)
Funders
  • National Science Foundation (CHE-2108223)
  • NIH Biotechnology Training Grant (T32 GM135066)
Topics
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
neuropeptides, thermal acclimation, Homarus americanus, peptidomics, heat tolerance, RFamide, leucokinin, pyrokinin, allatostatin, sinus gland, stomatogastric ganglion, global warming

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