Regulation of exosome production and cargo sorting
Open accessAbstract
Cellular communication can be mediated by the exchange of biological information, mainly in the form of proteins and RNAs. This can occur when extracellular vesicles, such as exosomes, secreted by a donor cell are internalized by an acceptor cell. Exosomes bear specific repertoires of proteins and RNAs, indicating the existence of mechanisms that control the sorting of molecules into them. Knowledge about loadings and processes and mechanisms of cargo sorting of exosomes is essential to shed light on the physiological and pathological functions of these vesicles as well as on clinical applications involving their use and/or analysis. In this review, we will discuss the molecular mechanisms associated with exosome secretion and their specific cargo sorting, with special attention to the sorting of RNAs and proteins, and thus the outcome and the emerging therapeutic opportunities of the communication between the exosome-producer and recipient cells.
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Exosomes contain a plentiful number of proteins and genetic molecules, allowing most biological substances to be loaded without unexpected interactions with the carrier.
“A plentiful number of proteins and genetic molecules as a component in exosomes indicate that the great majority of biological substances can be loaded without unexpected interactions with the carrier.”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [28]
Exosomes have superior compatibility critical to their function as carriers and a tremendous inherent capacity for receiver cells.
“They have superior compatibility that is critical to their function as carriers [28], which also shows a tremendous inherent capacity for receiver cells [29].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [28]
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References 188 · Cited by 385
- Authors
- Wei, H., Chen, Q., Lin, L., Sha, C., Li, T., Liu, Y., Yin, X., Xu, Y., Chen, L., Gao, W., Li, Y., & Zhu, X.
- Affiliations
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Corresponding author
- Li, Yuefeng
- Zhu, Xiaolan
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 17
- Issue
- 1
- Pages
- 163-177
- ISSN
- 1449-2288 (ISSN-L)
- PMC
- PMC7757038
- OpenAlex
- W3111273864
- Cited by
- 385
- References
- 188
- Citations by year
- 2026: 53 · 2025: 71 · 2024: 105 · 2023: 69 · 2022: 58 · 2021: 29
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- International Journal of Biological Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China (81871343, 81672913/81871343, 81672913)
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province (BK20181226)
- Jiangsu Provincial Medical Youth Talent (QNRC2016460, FRC201788)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- exosomes, extracellular vesicles, exosome secretion, cargo sorting, protein sorting, intercellular communication
- MeSH terms
- Organelle Biogenesis, Biological Therapy, Humans, Biomarkers, Exosomes, Secretory Pathway
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