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The Heparan and Heparin Metabolism Pathway is Involved in Regulation of Fatty Acid Composition
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Several DEGs previously associated with lipid metabolism were identified, including MIAT, COMT, NRP1, VEGFB, GRAMD1B, DSEL, and FUT9 associated with glycan structure.
“We identified several DEGs that have been previously associated with lipid metabolism, including MIAT, COMT, NRP1, VEGFB, GRAMD1B, DSEL56–62, as well as FUT9 associated with glycan structure63,64 (Fig. 4a).”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [62]
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Research works printed but not linked: 15
- [1]Torkamani A Topol EJ Schork NJ Pathway analysis of seven common diseases assessed by genome-wide association Genomics 2008 92 265 72 18722519 PMC2602835
- [2]Kolset SO Salmivirta M Cell surface heparan sulfate proteoglycans and lipoprotein metabolism Cell Mol Life Sci 1999 56 857 70 11212344 PMC11146903
- [3]Wilsie LC Chanchani S Navaratna D Orlando RA Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes Lipids Health Dis 2005 4 2 15636641 PMC545935
- [4]Cupp M Bensadoun A Melford K Heparin decreases the degradation rate of lipoprotein lipase in adipocytes J Biol Chem 1987 262 6383 8 3553188
- [5]Luo W Shitaye H Friedman M Disruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiation Exp Cell Res 2008 314 3382 91 18674534 PMC3179914
- [6]Daniels TF Wu XL Pan Z The reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth in beef cattle PLoS One 2010 5 e15203 21151936 PMC2997077
- [7]Jiang Z Michal JJ Tobey DJ Comparative understanding of UTS2 and UTS2R genes for their involvement in type 2 diabetes mellitus Int J Biol Sci 2008 4 96 102 18463714 PMC2359900
- [8]Alexander LJ Macneil MD Geary TW Quantitative trait loci with additive effects on palatability and fatty acid composition of meat in a Wagyu-Limousin F2 population Anim Genet 2007 38 506 13 17894565
- [9]Jiang Z Michal JJ Chen J Discovery of novel genetic networks associated with 19 economically important traits in beef cattle Int J Biol Sci 2009 5 528 42 19727437 PMC2726579
- [11]Akaike H A new look at the statistical model identification IEEE Trans Automat Contr 1974 19 716 723
- [12]Bishop JR Stanford KI Esko JD Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism Curr Opin Lipod 2008 19 307 13 18460924
- [13]Kim BT Kitagawa H Tamura J Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis Proc Natl Acad Sci U S A 2001 98 7176 81 11390981 PMC34642
- [14]Busse M Feta A Presto J Wilén M Grønning M Kjellén L Kusche-Gullberg M Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation J Biol Chem 2007 282 32802 10 17761672
- [15]Foley EM Esko JD Hepatic heparan sulfate proteoglycans and endocytic clearance of triglyceride-rich lipoproteins Prog Mol Biol Transl Sci 2010 93 213 33 20807647
- [16]Chen K Liu ML Schaffer L Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins Hepatology 2010 52 1957 67 21049473 PMC2991429
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GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Acosta Ingram, D., Turkes, E., Kim, T. Y., Vo, S., Sweeney, N., Bonte, M.-A., Rutherford, R., Julian, D. L., Pan, M., Marsh, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58585-w · Cited by 12
Metadata
- Authors
- Jiang, Z., Michal, J. J., Wu, X.-L., Pan, Z., & MacNeil, M. D.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2011
- Volume
- 7
- Issue
- 5
- Pages
- 659-663
- ISSN
- 1449-2288
- PMC
- PMC3107474
- Cited by
- 22
- References
- 0
- Language
- en
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