The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Alanine Aminotransferase-Old Biomarker and New Concept: A Review
Open accessAbstract
Measurement of serum alanine aminotransferase (ALT) is a common, readily available, and inexpensive laboratory assay in clinical practice. ALT activity is not only measured to detect liver disease, but also to monitor overall health. ALT activity is influenced by various factors, including viral hepatitis, alcohol consumption, and medication. Recently, the impact of metabolic abnormalities on ALT variation has raised concern due to the worldwide obesity epidemic. The normal ranges for ALT have been updated and validated considering the metabolic covariates in the various ethnic districts. The interaction between metabolic and demographic factors on ALT variation has also been discussed in previous studies. In addition, an extremely low ALT value might reflect the process of aging, and frailty in older adults has been raised as another clinically significant feature of this enzyme, to be followed with additional epidemiologic investigation. Timely updated, comprehensive, and systematic introduction of ALT activity is necessary to aid clinicians make better use of this enzyme.
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Cited by
Coelho, F. D. S., Borges‐Canha, M., von Hafe, M., Neves, J. S., Vale, C., Leite, A. R., Carvalho, D., & Leite‐Moreira, A. (2021) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3413 · Cited by 61
Aslam, H., Trakman, G., Dissanayake, T., Todd, E., Harrison, P., Alby, C., Jabeen, T., Gamage, E., Travica, N., Marshall, S., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-025-07428-9 · Cited by 30
Metadata
- Authors
- Liu, Z., Que, S., Xu, J., & Peng, T.
- Venue
- International Journal of Medical Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2014
- Volume
- 11
- Issue
- 9
- Pages
- 925-935
- ISSN
- 1449-1907 (ISSN-L)
- OpenAlex
- W2171329760
- Cited by
- 266
- References
- 141
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
